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Novel dual-target CAR T cell therapy shows promise in treating recurrent glioblastoma

Targeting two brain tumor-associated proteins-;rather than one-;with CAR T cell therapy shows promise as a strategy for reducing solid tumor growth in patients with recurrent glioblastoma (GBM), an aggressive form of brain cancer, according to early results from the first six patients treated in an ongoing Phase I clinical trial led by researchers from the Perelman School of Medicine at the University of Pennsylvania and Penn Medicine's Abramson Cancer Center.

13 Mar 2024

Study unravels FOXO1's influence on blood vessel development

The human vascular system, a complex network of blood vessels, plays an essential role in maintaining health. Understanding the molecular mechanisms underlying vascular development is important for tackling age-related disorders.

9 Mar 2024

Study reveals nerve changes linked to pain and urinary frequency in recurrent UTI sufferers

How sensory nerve sprouting and mast cell activity, driven by nerve growth factor (NGF), contribute to persistent bladder pain and dysfunction in recurrent urinary tract infection (rUTI) cases.

7 Mar 2024

Even low levels of leisure-time physical activity can prevent stroke in the long term

Recently, scientists conducted a systematic review and metaanalysis to understand better whether different levels of leisure-time physical activity (LTPA) prevent stroke.

6 Mar 2024

Human molecular adaptations to fasting: Insights from proteomic analysis

Researchers investigate systemic proteome adaptations to one week of fasting in humans.

6 Mar 2024

Sacituzumab govitecan plus platinum-based chemotherapy effective in multiple carcinomas

A new research paper was published in Oncotarget's Volume 15 on February 22, 2024, entitled, "Sacituzumab govitecan plus platinum-based chemotherapy mediates significant antitumor effects in triple-negative breast, urinary bladder, and small-cell lung carcinomas."

5 Mar 2024

Exonate first-in-class eye drop Phase Ib/IIa trial data demonstrate safety and biological activity in treatment of diabetic retinopathy and diabetic macular oedema

EXN407 is the first topical SRPK1 inhibitor to demonstrate both safety and signals of biological response as monotherapy for these indications.

5 Mar 2024

Unlocking the secrets of T follicular helper cells for better treatment strategies

T follicular helper cells (Tfh) are essential for strong antibody-mediated reactions of our immune system during infections and vaccinations. However, if they get out of control, this can cause diseases such as autoimmunity, allergies or cancer.

1 Mar 2024

Nerve overgrowth identified as cause of pain in recurring UTIs

A perplexing problem for people with recurring urinary tract infections (UTIs) is persistent pain, even after antibiotics have successfully cleared the bacteria.

1 Mar 2024

Association of volatile aromatic compounds in blood with hearing impairment

The impact of benzene, ethylbenzene, and xylene (BEX) exposure on auditory health.

1 Mar 2024

UB research may offer a more streamlined approach to developing cancer drugs

Drug discovery can be a frustrating process of trial and error.

28 Feb 2024

Investigational protein replacement protects neonatal mice from deadly intestinal disease

Scientists from Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago and colleagues found that an investigational protein replacement – recombinant human insulin-like growth factor 1 and its binding protein-3 (rhIGF-1/BP3) – protected neonatal mice from necrotizing enterocolitis (NEC), a deadly intestinal disease that often strikes extremely premature infants.

28 Feb 2024

Resistant starch diet proves a game changer for weight loss and diabetes control

Supplementation with resistant starch leads to weight loss and improved insulin sensitivity by altering the gut microbiome and increasing secondary bile acids, according to a recent study in Nature Metabolism.

27 Feb 2024

Boston College biologist wins NIH grant to study viral insulins for cancer treatment

Boston College Assistant Professor of Biology Emrah Altindis has been awarded a five-year, $2.5-million grant from the National Institutes of Health to study viral insulins and mechanisms related to IGF-1 receptor protein inhibition and its potential applications in cancer treatment.

26 Feb 2024

Can dietary patterns impact stomach cancer risk?

Eating patterns and indices related to gastric cancer and explored their association with stomach cancer risk.

22 Feb 2024

Researchers develop artificial cell environment to promote nerve regeneration

Injuries in the central nervous system heal poorly because cavities scar. Researchers hope to remedy this problem by filling the cavities in such a way that stem cells feel comfortable in them.

20 Feb 2024

Study suggests CT imaging with automated AI system predicts EGFR genotype, identifying mutation status cost-effectively and non-invasively

Researchers developed an artificial intelligence (AI)-based predictive system (AIPS) model for the early detection of lung cancer by combining radiological, clinical, and genetic data.

16 Feb 2024

Growth Factor News and Research

Novel dual-target CAR T cell therapy shows promise in treating recurrent glioblastoma

Study unravels FOXO1's influence on blood vessel development

Study reveals nerve changes linked to pain and urinary frequency in recurrent UTI sufferers

Even low levels of leisure-time physical activity can prevent stroke in the long term

Human molecular adaptations to fasting: Insights from proteomic analysis

Sacituzumab govitecan plus platinum-based chemotherapy effective in multiple carcinomas

Exonate first-in-class eye drop Phase Ib/IIa trial data demonstrate safety and biological activity in treatment of diabetic retinopathy and diabetic macular oedema

Unlocking the secrets of T follicular helper cells for better treatment strategies

Nerve overgrowth identified as cause of pain in recurring UTIs

Association of volatile aromatic compounds in blood with hearing impairment

UB research may offer a more streamlined approach to developing cancer drugs

Investigational protein replacement protects neonatal mice from deadly intestinal disease

Resistant starch diet proves a game changer for weight loss and diabetes control

Boston College biologist wins NIH grant to study viral insulins for cancer treatment

Can dietary patterns impact stomach cancer risk?

Researchers develop artificial cell environment to promote nerve regeneration

Study suggests CT imaging with automated AI system predicts EGFR genotype, identifying mutation status cost-effectively and non-invasively

How maternal diet composition influences offspring appetite and metabolic health

Researchers discover new mechanism of action between the nutrient adaptation of intestinal stem cells and aging

Novel three-drug combo shows promise in advanced HER2-negative breast cancer treatment

Discover how SciY empowers scientists

Why use light scattering to analyze proteins and viral vectors?

Changing the landscape of R&D to build clinical success from the ground up

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