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Unlocking the anti-inflammatory secrets of bergamot byproducts

The positive effect of bergamot derivatives.

17 Jan 2024

TRPC3 emerges as key player in preventing damage from alcohol-associated liver disease

Excessive alcohol intake is strongly associated with alcohol-associated liver disease (ALD) which accounts for 25% and 30% of deaths from cirrhosis and hepatocellular carcinoma. Impairment of Ca2+ influx and Ca2+-mediated signaling in ALD suggests that Ca2+ channels are important in ALD pathological progression.

16 Jan 2024

GRK2: A new target for inhibiting macrophage infiltration and angiogenesis in rheumatoid arthritis

This new article publication from Acta Pharmaceutica Sinica B, discusses how GRK2 inhibits Flt-1+ macrophage infiltration and its proangiogenic properties in rheumatoid arthritis.

15 Jan 2024

Revolutionary AI tool forecasts kidney injury signs with high accuracy in intensive care

A machine-learning (ML) algorithm for predicting oliguria.

15 Jan 2024

Pazopanib activity confirmed in EWSR1-NFATC2 bone sarcoma

A new case report was published in Oncoscience (Volume 10) on September 20, 2023, entitled, "Activity of pazopanib in EWSR1-NFATC2 translocation-associated bone sarcoma."

12 Jan 2024

Breakthrough in diabetes management: Cold water exercise and cinnamon shows promising results

The effects of swimming and cinnamon supplementation on TBC1D1, HbA1C levels, and TBC1D4.

12 Jan 2024

Key protein EPAC1 found to regulate brown fat growth, offering obesity treatment potential

Study reveals that EPAC1 protein plays a crucial role in regulating the growth of brown and beige adipose tissue, offering potential avenues for treating obesity and improving cardiometabolic health.

11 Jan 2024

Glioblastoma tumor cells mimic neurons to evade treatment

Certain cancers are more difficult to treat because they contain cells that are highly skilled at evading drugs or our immune systems by disguising themselves as healthy cells.

11 Jan 2024

Non-smokers' lung cancer among top five global cancer-related deaths in 2023

The development of lung cancer in individuals who have never smoked.

11 Jan 2024

Sesame oil supplementation: a potential breakthrough in postmenopausal osteoporosis prevention?

Daily sesame oil supplementation in ovariectomized rats was found to prevent osteoporosis by enhancing bone formation, reducing bone resorption, and maintaining serum estrogen and aromatase levels.

7 Jan 2024

Unlocking the power of diet: How miRNAs influence health and disease

The role of dietary microRNAs (miRNAs) in health and disease.

5 Jan 2024

GFH009 disrupts growth signals and triggers apoptosis in hematologic malignancies

A new research paper was published in Oncotarget's Volume 14 on December 20, 2023, entitled, "The pharmacodynamic and mechanistic foundation for the antineoplastic effects of GFH009, a potent and highly selective CDK9 inhibitor for the treatment of hematologic malignancies."

28 Dec 2023

Common inflammation pathway turns anthrax toxin into killer

Bacillus anthracis lethal toxin (LT) is a determinant of lethal anthrax. Its function in myeloid cells is required for bacterial dissemination, and LT itself can directly trigger dysfunction of the cardiovascular system.

26 Dec 2023

Study sheds light on enzyme's role in advanced prostate cancer progression

Prostate cancer is the most common cancer in men other than skin cancer, and more than 288,000 new cases are diagnosed every year, according to the American Cancer Society.

21 Dec 2023

St. Jude researchers reveal structure of Parkinson's-linked proteins

Scientists at St. Jude Children's Research Hospital revealed the complex structure of two Parkinson's disease-related proteins, both of which are implicated in late-onset cases.

21 Dec 2023

Cinnamon extract shows promise in reducing obesity by inhibiting fat cell growth and boosting fat breakdown

Study reveals that cinnamon extract significantly inhibits adipocyte differentiation and lipid accumulation, offering potential benefits against obesity by reducing fat production and enhancing lipolysis in both cell models and mice.

18 Dec 2023

New methodology may be important in the fight against antimicrobial resistance

NTNU has developed a promising antibiotic candidate against MRSA. Behind the discovery lies a methodology that may be important in the fight against antimicrobial resistance.

15 Dec 2023

Researchers unveil new way to sensitize resistant tumors to treatment

Resistance to therapies is one of the obstacles to overcome in cancer treatments. Understanding the mechanisms of this resistance is essential to design strategies that favor tumor cell death.

14 Dec 2023

Quizartinib extends life and enhances wellbeing for AML patients with key mutation

In a study led by researchers at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine, patients recently diagnosed with a common and aggressive form of acute myeloid leukemia reported having improved quality of life when a newly approved drug was part of the treatment plan.

11 Dec 2023

Research uncovers potential treatment target for rare, genetic type of epilepsy

Researchers at the Francis Crick Institute, UCL and MSD have identified a potential treatment target for a genetic type of epilepsy.

11 Dec 2023

Kinase News and Research

Unlocking the anti-inflammatory secrets of bergamot byproducts

TRPC3 emerges as key player in preventing damage from alcohol-associated liver disease

GRK2: A new target for inhibiting macrophage infiltration and angiogenesis in rheumatoid arthritis

Revolutionary AI tool forecasts kidney injury signs with high accuracy in intensive care

Pazopanib activity confirmed in EWSR1-NFATC2 bone sarcoma

Breakthrough in diabetes management: Cold water exercise and cinnamon shows promising results

Key protein EPAC1 found to regulate brown fat growth, offering obesity treatment potential

Glioblastoma tumor cells mimic neurons to evade treatment

Non-smokers' lung cancer among top five global cancer-related deaths in 2023

Sesame oil supplementation: a potential breakthrough in postmenopausal osteoporosis prevention?

Unlocking the power of diet: How miRNAs influence health and disease

GFH009 disrupts growth signals and triggers apoptosis in hematologic malignancies

Common inflammation pathway turns anthrax toxin into killer

Study sheds light on enzyme's role in advanced prostate cancer progression

St. Jude researchers reveal structure of Parkinson's-linked proteins

Cinnamon extract shows promise in reducing obesity by inhibiting fat cell growth and boosting fat breakdown

New methodology may be important in the fight against antimicrobial resistance

Researchers unveil new way to sensitize resistant tumors to treatment

Quizartinib extends life and enhances wellbeing for AML patients with key mutation

Research uncovers potential treatment target for rare, genetic type of epilepsy

Discover how SciY empowers scientists

Why use light scattering to analyze proteins and viral vectors?

Changing the landscape of R&D to build clinical success from the ground up

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