Pathophysiology News and Research

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Developing a virtual twin for personalized cancer treatment with CAR-T cell therapy

In recent years, cancer immunotherapies have established themselves as a further pillar of medical oncology alongside traditional treatment options (surgery, radiotherapy and chemotherapy).

13 Dec 2023

Innovative robotic right ventricle developed to mimic heart biomechanics

Researchers modeled the right ventricle (RV) to create a robot replicating right ventricular hemodynamics and biomechanics.

13 Dec 2023

Anti-obesity medications may offer survival benefits for osteoarthritis patients

New research published in Arthritis & Rheumatology suggests that for people overweight or with obesity who also have knee or hip osteoarthritis, a slow-to-moderate-;but not fast-;rate of weight loss caused by anti-obesity medications may lower their risk of premature death.

6 Dec 2023

Link between gut dysbiosis and chronic diseases explored in new study

Study explores the ecological causes of gut dysbiosis and its link to human diseases, revealing how imbalances in gut microbiota composition, influenced by host-derived factors like oxygen and nitrate, contribute to various chronic conditions.

5 Dec 2023

Marshall School of Medicine dean named to the 2023 list of Highly Cited Researchers

David Gozal, M.D., M.B.A., Ph.D. (Hon), vice president of health affairs and dean of the Joan C. Edwards School of Medicine at Marshall University, was named to the 2023 list of Highly Cited Researchers list by Clarivate.

5 Dec 2023

Evaluating the safety and efficacy of thalamic DBS in treating traumatic brain injury

The safety and efficacy of deep brain stimulation.

4 Dec 2023

Neural patterns unravel distinctions between traumatic and sad memories in individuals with PTSD

Researchers investigate the neural patterns of patients with PTSD while listening to narratives that depicted their own memories.

30 Nov 2023

Traumatic memories represented differently in the brain, study finds

A new analysis of the brain activity of people with post-traumatic stress disorder (PTSD) is the first to reveal that traumatic memories are represented in the brain in an entirely different way than sad autobiographical memories.

30 Nov 2023

Imaging approach provides objective evidence for the involvement of neck muscles in primary headaches

Researchers have identified objective evidence of how the neck muscles are involved in primary headaches, according to a study being presented today at the annual meeting of the Radiological Society of North America.

29 Nov 2023

Revolutionary advances in psoriasis treatment: unveiling new therapeutic approaches

Psoriasis etiopathogenesis and treatment.

29 Nov 2023

Study finds diet-derived trans-vaccenic acid boosts anti-tumor immunity

Dietary components that impact anti-tumor immunity.

28 Nov 2023

New insights into how SARS-CoV-2 evades our immune system

This review in Cellular and Molecular Immunology delves into the innate immune response to SARS-CoV-2, exploring how the virus evades immunity and the potential role of innate immunity in long-COVID and vaccine responses, shedding light on future therapeutic strategies.

23 Nov 2023

Genome study unveils genetic ties between cannabis use disorder and lung cancer risk

A genome-wide association study in Nature Genetics reveals insights into the genetics of cannabis use disorder, highlighting its strong association with psychopathology and a causal link to lung cancer, and suggesting distinct genetic pathways from mere cannabis use.

23 Nov 2023

New study reveals increased cancer risk linked to higher BMI in adults with cardiovascular diseases

The joint and individual correlations of CVD/T2D and BMI with cancer risk.

23 Nov 2023

Avian influenza A H5N1 virus impacts wide range of wildlife in the U.S., study shows

Study highlights the spread of the highly pathogenic avian influenza A (H5N1) virus among non-domesticated animals in the U.S., revealing neurological symptoms as a key clinical presentation and expanding the range of species affected by this Eurasian lineage virus.

19 Nov 2023

Molecular trap offers hope for ALS treatment

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that affects neurons in the brain and spinal cord causing loss of muscle control.

16 Nov 2023

Intestinal MCT1 plays a crucial role in sex-dependent metabolic regulation

Monocarboxylate transporter 1 (MCT1) plays a crucial role in the transport of lactate, pyruvate, ketone bodies, and short-chain fatty acids (SCFA), as well as MCT1-targeted drugs in various tissues.

14 Nov 2023

Obinutuzumab shows promise in preserving kidney function, preventing flares in lupus nephritis patients

In a post hoc analysis of the phase 2 NOBILITY trial, researchers found that treatment with obinutuzumab-;an antibody that targets a protein expressed on certain immune cells-;was superior to placebo for preserving kidney function and preventing flares in patients with lupus nephritis, a kidney condition associated with the autoimmune disease lupus.

10 Nov 2023

High levels of anti-Ro/SSA antibodies linked to fetal heart block in pregnant women

Some individuals with anti-Ro/SSA antibodies (anti–Sjögren's-syndrome–related antigen A autoantibodies, also called anti-Ro antibodies) have autoimmune diseases such as lupus or Sjögren's syndrome, but many have no symptoms.

10 Nov 2023

Research redefines rheumatoid arthritis: Over 314,000 cells analyzed for precise treatment strategies

A new paper recently published in Nature, reported the examination of synovial tissue from the joints of nearly 80 people with RA, in combination with RNA sequencing and surface protein analyses.

10 Nov 2023

Pathophysiology News and Research

Developing a virtual twin for personalized cancer treatment with CAR-T cell therapy

Innovative robotic right ventricle developed to mimic heart biomechanics

Anti-obesity medications may offer survival benefits for osteoarthritis patients

Link between gut dysbiosis and chronic diseases explored in new study

Marshall School of Medicine dean named to the 2023 list of Highly Cited Researchers

Evaluating the safety and efficacy of thalamic DBS in treating traumatic brain injury

Neural patterns unravel distinctions between traumatic and sad memories in individuals with PTSD

Traumatic memories represented differently in the brain, study finds

Imaging approach provides objective evidence for the involvement of neck muscles in primary headaches

Revolutionary advances in psoriasis treatment: unveiling new therapeutic approaches

Study finds diet-derived trans-vaccenic acid boosts anti-tumor immunity

New insights into how SARS-CoV-2 evades our immune system

Genome study unveils genetic ties between cannabis use disorder and lung cancer risk

New study reveals increased cancer risk linked to higher BMI in adults with cardiovascular diseases

Avian influenza A H5N1 virus impacts wide range of wildlife in the U.S., study shows

Molecular trap offers hope for ALS treatment

Intestinal MCT1 plays a crucial role in sex-dependent metabolic regulation

Obinutuzumab shows promise in preserving kidney function, preventing flares in lupus nephritis patients

High levels of anti-Ro/SSA antibodies linked to fetal heart block in pregnant women

Research redefines rheumatoid arthritis: Over 314,000 cells analyzed for precise treatment strategies

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From Discovery Biology to ELRIG Chair

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