Autoimmunity News and Research

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Autoimmune Disease is a condition in which the body recognizes its own tissues as foreign and directs an immune response against them.

Dendritic cells turn T cells into T regs

Regulatory T cells (also known as T regs) suppress some of the immune system's more inappropriate responses, preventing it from attacking the body's own tissues and stifling its activity once invading microbes have been fought off.

17 Sep 2007

Reducing inflammation plays key role in type 1 diabetes therapy

Researchers at Beth Israel Deaconess Medical Center (BIDMC) have found that a triple combination therapy consisting of both tolerance-inducing and anti-inflammatory properties is successful in abolishing adverse autoimmunity against insulin-producing cells in a mouse model of Type 1 diabetes.

1 Aug 2007

Interferon-alpha levels may predict who might be at risk to develop lupus

Certain families produce higher levels of a specific molecule, called interferon-alpha, that primes the body's immune system to turn on, and in some cases initiate an autoimmune attack on itself, according to new research from Hospital for Special Surgery in New York City.

1 Aug 2007

Umbilical cord blood may safely preserve insulin production in children newly diagnosed with type 1 diabetes

University of Florida researchers sought to determine whether it is feasible to use a patient's own cord blood stem cells to neutralize the body's autoimmune attack on the pancreas and help restore the organ's ability to make insulin, which regulates how the body uses sugar and other nutrients for energy.

27 Jun 2007

Protein S-100 linked to melanoma recurrence

Higher levels of a protein called S-100 in patients with melanoma may correlate with a higher risk of having the disease return, say researchers at the University of Pittsburgh Cancer Institute (UPCI), who presented their findings today at the annual meeting of the American Society of Clinical Oncology (ASCO) in Chicago.

5 Jun 2007

Study tests oral insulin to prevent type 1 diabetes

University of Florida researchers have begun a clinical study of oral insulin to prevent or delay type 1 diabetes in people at risk for the disease.

3 Jun 2007

Scientists develop method to track immune system enzyme in live animals

Scientists supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) at the National Institutes of Health have created two mouse strains that will permit researchers to trace, in a live animal, the activity of an enzyme believed to play a crucial role both in the normal immune response as well as autoimmunity and B cell tumor development.

18 May 2007

Glucosamine-like dietary supplement suppresses autoimmune response in multiple sclerosis and type-1 diabetes mellitus

This finding shows the potential of using a dietary supplement to help treat autoimmune diseases, said Demetriou, an assistant professor of neurology, and microbiology and molecular genetics.

15 May 2007

Promising new target for brain tumor therapy

A drug that targets the body's immune cells may be effective in treating malignant brain tumors, according to a new study led by researchers from Duke's Preston Robert Tisch Brain Tumor Center.

9 May 2007

Prenatal toxicity linked to immune dysfunctions in later life

A Cornell researcher and his wife have conducted the first comprehensive review of later-life diseases that develop in people who were exposed to environmental toxins or drugs either in the womb or as infants.

4 May 2007

World's first microRNA knockout mouse

A role for a microRNA in the immune system has been shown by study of one of the world's first microRNA knockout mouse, reported in Science.

27 Apr 2007

Green tea may help protect against Sjogren's syndrome

They found significantly less salivary gland damage in a group treated with green tea extract, suggesting a reduction of the Sjogren's symptom commonly referred to as dry mouth. Dry mouth can also be caused by certain drugs, radiation and other diseases.

20 Apr 2007

Link between immune system and high plasma lipid levels

Researchers at the University of Chicago have found an unsuspected link between the immune system and high plasma lipid levels (cholesterol and triglycerides in the blood) in mice.

15 Apr 2007

Vitiligo gene linked to other autoimmune diseases

In a study appearing in the March 22 New England Journal of Medicine, scientists supported by the National Institutes of Health's National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) have discovered a connection between a specific gene and the inflammatory skin condition vitiligo, as well as a possible host of autoimmune diseases.

11 Apr 2007

Researchers show blood-brain barrier damage could affect multiple sclerosis severity

Immunology researchers at the Kimmel Cancer Center at Jefferson studying a multiple sclerosis (MS)-like disease in mice have shown that the amount of "damage" to the central nervous system's protective blood-brain barrier, in essence, opening it, almost always correlates to the severity of the disease.

7 Apr 2007

Connection found between allergic diseases and autoimmune diseases

A new study by researchers at Children's Hospital and Regional Medical Center and the University of Washington (UW) identifies a connection between allergic diseases such as atopic dermatitis, also known as eczema, and autoimmune diseases. The study was published in the April 1, 2007 edition of Nature Immunology.

4 Apr 2007