Medicinal Chemistry News and Research

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New compounds can provide a breakthrough in the treatment of neurodegenerative pathologies

Russian scientists have synthesized chemical compounds that can stop the degeneration of neurons in Alzheimer's, Parkinson's, and other severe brain pathologies. These substances can provide a breakthrough in the treatment of neurodegenerative pathologies.

19 Jul 2021

Reactive oxygen species are important components in cancer treatments

Reactive oxygen species (ROS) are highly reactive chemicals which contain oxygen radicals. Hypochlorous acid, peroxides, superoxide, singlet oxygen, alpha-oxygen and hydroxyl radicals are the major examples of ROS, which are familiar to persons from many walks of life as they are used in many domestic and industrial processes.

1 Jul 2021

LSL60101 compound improves cognitive deficit in murine models with Alzheimer’s

The LSL60101 compound, a specific ligand of the I2-IR receptors in the brain, could shed light on the development of future strategies against Alzheimer's disease.

29 Jun 2021

Sunflower peptide identified as a potential drug for treating abdominal pain

A naturally occurring peptide in sunflower seeds was synthetically optimised and has now been identified as a potential drug for treating abdominal pain or inflammation (in the gastrointestinal tract, abdominal area and/or internal organs).

28 Jun 2021

New book reveals promising nanomaterials for therapeutic drug delivery

'Nanomaterials: Evolution and Advancement Towards Therapeutic Drug Delivery' gives the present status and future perspective of Polymeric nanoparticles, Liposomes, Carbon Nanotubes, Magnetic Nanoparticles, Silica Based nanomaterial, Hydrogels, Metallic Nanoparticles, Cyclodextrins, Poly (Lactide-Co-Glycolide) and its Copolymers.

25 Jun 2021

New class of compounds can stop the reproduction of coronavirus

A human genetic mechanism hijacked by SARS-CoV-2, the coronavirus behind the COVID-19 pandemic, to help it spread also makes it vulnerable to a new class of drug candidates, a new study finds.

24 Jun 2021

Researchers discover new class of drugs that inhibits a 'master switch' in mantle cell lymphoma

A new class of drugs that inhibits a "master switch" involved in the vast majority of cases of mantle cell lymphoma (MCL), a fatal subtype of non-Hodgkin's lymphoma, has been discovered by researchers at Mount Sinai.

22 Jun 2021

Virginia Tech researcher receives $2.2 million to advance study on small 'fat burning' molecules

The liver is the most resilient organ in the human body. It can remove toxins from the bloodstream, recycle red blood cells, maintain sugar levels, and it can even regenerate itself. But, when a large amount of fat builds up in the liver, it becomes too inflamed to perform its crucial duties.

14 Jun 2021

Scientists identify many existing drugs with antiviral activity against coronavirus

Mining the world's most comprehensive drug repurposing collection for COVID-19 therapies, scientists have identified 90 existing drugs or drug candidates with antiviral activity against the coronavirus that's driving the ongoing global pandemic.

3 Jun 2021

Known pharmaceutical compounds could provide new therapies for COVID-19

After screening over 12,000 existing treatments, researchers have found many promising antiviral compounds that could treat COVID-19.

3 Jun 2021

E6-specific inhibitors offer a unique, strategic approach for treating HPV-HNSCC

Oncotarget published "A high-content AlphaScreen™ identifies E6-specific small molecule inhibitors as potential therapeutics for HPV+ head and neck squamous cell carcinomas" which reported that the incidence of human papillomavirus-positive head and neck squamous cell carcinoma has increased dramatically over the past decades due to an increase in infection of the oral mucosa by HPV.

3 Jun 2021

Researchers develop chemical probe to fight against antibiotic-resistant bacteria

In the perpetual arms races between bacteria and human-made antibiotics, there is a new tool to give human medicine the edge, in part by revealing bacterial weaknesses and potentially by leading to more targeted or new treatments for bacterial infections.

28 May 2021

New peptides allow cannabis-derived drugs to fight pain in mice without side effects

An international team, led by researchers from Pompeu Fabra University (UPF) in Barcelona, Spain, David Andreu and Rafael Maldonado, has developed a peptides family that allows delta-9-tetrahydrocannabinol (THC), the main component of Cannabis sativa, to fight pain in mice without side effects.

20 May 2021

New peptide could allow cannabis to fight pain without side effects

Many people live with chronic pain, and in some cases, cannabis can provide relief. But the drug also can significantly impact memory and other cognitive functions.

12 May 2021

New insights into how South African SARS-CoV-2 variant sacrifices tight binding for antibody evasion

The highly infectious SARS-CoV-2 variant that recently emerged in South Africa, known as B.1.351, has scientists wondering how existing COVID-19 vaccines and therapies can be improved to ensure strong protection.

29 Apr 2021

Drug-discovery collaboration finds potential new antimalarial drug candidates

Potential new antimalarial drug candidates are being developed through an extended drug-discovery collaboration between Australian medical research institute WEHI and Janssen Pharmaceutica NV. The collaboration was facilitated by Johnson & Johnson Innovation.

22 Apr 2021

Medicinal Chemistry News and Research

New compounds can provide a breakthrough in the treatment of neurodegenerative pathologies

Reactive oxygen species are important components in cancer treatments

LSL60101 compound improves cognitive deficit in murine models with Alzheimer’s

Sunflower peptide identified as a potential drug for treating abdominal pain

New book reveals promising nanomaterials for therapeutic drug delivery

New class of compounds can stop the reproduction of coronavirus

Researchers discover new class of drugs that inhibits a 'master switch' in mantle cell lymphoma

Virginia Tech researcher receives $2.2 million to advance study on small 'fat burning' molecules

Scientists identify many existing drugs with antiviral activity against coronavirus

Known pharmaceutical compounds could provide new therapies for COVID-19

E6-specific inhibitors offer a unique, strategic approach for treating HPV-HNSCC

Researchers develop chemical probe to fight against antibiotic-resistant bacteria

New peptides allow cannabis-derived drugs to fight pain in mice without side effects

New peptide could allow cannabis to fight pain without side effects

New insights into how South African SARS-CoV-2 variant sacrifices tight binding for antibody evasion

Drug-discovery collaboration finds potential new antimalarial drug candidates

Rare compound found in a shrub could help fight previously 'undruggable' cancer protein

Scientists receive NIH grant to develop an adjuvant vaccine for opioid use disorder

Previously approved drugs starting points for COVID-19 therapeutics

Toward a transformative therapy for sickle cell patients

Discover how SciY empowers scientists

Why use light scattering to analyze proteins and viral vectors?

Changing the landscape of R&D to build clinical success from the ground up

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