Medicinal Chemistry News and Research

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Novel PF74 molecule effectively targets HIV capsid protein

Of all known small molecules targeting human immunodeficiency virus (HIV) capsid protein (CA), PF74 represents by far the best characterized chemotype, due to its ability to confer antiviral phenotypes in both early and late phases of viral replication.

9 Apr 2021

Novel diarylamides show promise as orally active diuretics to treat hyponatremia

Urea transporters (UT) play a vital role in the mechanism of urine concentration and are recognized as novel targets for the development of salt-sparing diuretics. Thus, UT inhibitors are promising for development as novel diuretics.

8 Apr 2021

Research offers an efficient approach to mine the chemical diversity of endophytic fungi

Endophytic fungi are promising producers of bioactive small molecules. Bioinformatic analysis of the genome of an endophytic fungus Penicillium dangeardii revealed 43 biosynthetic gene clusters, exhibited its strong ability to produce numbers of secondary metabolites.

8 Apr 2021

Acrylamide-based novel DHODH inhibitors as potential treatment for rheumatoid arthritis

Human dihydroorotate dehydrogenase (DHODH) is a viable target for the development of therapeutics to treat cancer and immunological diseases, such as rheumatoid arthritis (RA), psoriasis and multiple sclerosis (MS).

8 Apr 2021

Acrylamide-based DHODH inhibitors are potential agents for treating rheumatoid arthritis

Human dihydroorotate dehydrogenase(DHODH) is a viable target for the development of therapeutics to treat cancer andimmunological diseases, such asrheumatoid arthritis(RA), psoriasis andmultiple sclerosis(MS).

8 Apr 2021

Chemists successfully convert flat nitrogen-containing molecules into 3D structures

A major goal of organic and medicinal chemistry in recent decades has been the rapid synthesis of three-dimensional molecules for the development of new drugs.

26 Mar 2021

New compound may provide a basis for drug development against COVID-19

SARS-CoV-2, the virus responsible for the COVID-19 pandemic, arrived one year ago and turned our lives upside-down.

24 Mar 2021

New method for growing embryos outside the womb

To observe how a tiny ball of identical cells on its way to becoming a mammalian embryo first attaches to an awaiting uterine wall and then develops into nervous system, heart, stomach and limbs: This has been a highly-sought grail in the field of embryonic development for nearly 100 years.

17 Mar 2021

Understanding how a polymer inhibits ice re-crystallization could guide design of new cryoprotectants

When biological material (cells, blood, tissues) is frozen, cryoprotectants are used to prevent the damage associated with the formation of ice during the freezing process.

15 Mar 2021

Genome-wide CRISPR screening used to identify factors essential for SARS-CoV-2 infection in humans

In a methodologically trailblazing paper published in the journal Nature Genetics, a team of Belgian scientists uncovered an assembly of coronavirus host factors that may be exploited to develop drugs against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but also potentially forthcoming zoonotic coronaviruses.

14 Mar 2021

Compounds in green and black tea relax blood vessels by activating ion channel proteins

A new study from the University of California, Irvine shows that compounds in both green and black tea relax blood vessels by activating ion channel proteins in the blood vessel wall.

8 Mar 2021

New book focuses on rational drug design and discovery

Frontiers in Drug Design and Discovery is a book series devoted to publishing the latest and the most important advances in drug design and discovery.

25 Feb 2021

Study reveals the therapeutic applications of medicinal plants

Both Asia and Africa are home to many plants that can be used for the treatment of many diseases and their medicinal properties are gaining interest in western societies.

17 Feb 2021

Researchers develop new weapon to fight against resistant bacteria

Every day, people die from simple infections even though they have been treated with antibiotics. This is because more and more bacteria have become resistant to the types of antibiotics that doctors can prescribe.

10 Feb 2021

Optimizing the structure of drug delivery systems can help target cancer cells

The main culprit in cancer is healthy cells that have gone rogue and acquire the ability to divide uncontrollably.

28 Jan 2021

Scientists decipher the structure of protein found in parasites that cause neglected tropical diseases

Brazilian researchers have managed to decipher the structure of a protein found in parasites that cause neglected tropical diseases, paving the way to the development of novel medications.

8 Jan 2021

A paper-based sensor for detecting COVID-19

News-Medical talks to Dipanjan Pan about the development of a paper-based electrochemical sensor that can detect COVID-19 in less than five minutes.

5 Jan 2021

Toxic pesticide turned into treatment against antibiotic-resistant bacteria

N-Aryl-C-nitroazoles are an important class of heterocyclic compounds. They are used as pesticides and fungicides. However, these substances could be toxic to humans and cause mutations.

29 Dec 2020

First enzyme-driven biocatalytic production of nucleic acid building blocks

Researchers from TU Graz and acib succeed in the first enzyme-driven biocatalytic synthesis of nucleic acid building blocks. This facilitates the development of antiviral agents and RNA-based therapeutics.

15 Dec 2020

Oligourea-based "fake" peptides enhance options for rational drug design, shows study

Some useful drugs consist of peptides acting on their protein targets. To make them more efficient and stable, scientists have found a way to replace crucial segments of the peptides with ureido units.

8 Dec 2020

Medicinal Chemistry News and Research

Novel PF74 molecule effectively targets HIV capsid protein

Novel diarylamides show promise as orally active diuretics to treat hyponatremia

Research offers an efficient approach to mine the chemical diversity of endophytic fungi

Acrylamide-based novel DHODH inhibitors as potential treatment for rheumatoid arthritis

Acrylamide-based DHODH inhibitors are potential agents for treating rheumatoid arthritis

Chemists successfully convert flat nitrogen-containing molecules into 3D structures

New compound may provide a basis for drug development against COVID-19

New method for growing embryos outside the womb

Understanding how a polymer inhibits ice re-crystallization could guide design of new cryoprotectants

Genome-wide CRISPR screening used to identify factors essential for SARS-CoV-2 infection in humans

Compounds in green and black tea relax blood vessels by activating ion channel proteins

New book focuses on rational drug design and discovery

Study reveals the therapeutic applications of medicinal plants

Researchers develop new weapon to fight against resistant bacteria

Optimizing the structure of drug delivery systems can help target cancer cells

Scientists decipher the structure of protein found in parasites that cause neglected tropical diseases

A paper-based sensor for detecting COVID-19

Toxic pesticide turned into treatment against antibiotic-resistant bacteria

First enzyme-driven biocatalytic production of nucleic acid building blocks

Oligourea-based "fake" peptides enhance options for rational drug design, shows study

Discover how SciY empowers scientists

Why use light scattering to analyze proteins and viral vectors?

Changing the landscape of R&D to build clinical success from the ground up

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