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Does the percentage of slow-wave sleep decline with aging, and are intra-individual declines associated with dementia risk?

Researchers investigated whether slow-wave sleep (SWS) proportions reduced as individuals aged and whether intra-individual decreases were linked to dementia risk.

1 Nov 2023

How one gene shakes up our understanding of male infertility

The study investigates the role of the ACTL7B gene in sperm formation using genetically modified mice and finds that deficiencies in this gene lead to failed spermatogenesis and structural sperm abnormalities. Given the gene's similarity in humans, the findings suggest ACTL7B could serve as a potential biomarker for male infertility.

31 Oct 2023

Stopping metformin early linked to higher dementia risk in older adults with type 2 diabetes

Early termination of metformin treatment in older adults with type 2 diabetes is associated with a higher risk of dementia, according to a cohort study. The research has significant implications for diabetes management, especially among those at higher risk for dementia.

29 Oct 2023

Boosting brain health with iron and manganese: A dietary defense against cognitive decline

The recent study published in Nutrients explores the link between dietary mineral intake and cognitive impairment in elderly Spanish individuals, finding that increased consumption of iron and manganese significantly reduced cognitive impairment risk in women but showed no effect in men.

25 Oct 2023

Study challenges link between low birth weight and childhood neurodevelopmental issues

A recent study in JAMA Psychiatry used Mendelian Randomization to examine the link between low birth weight and neurodevelopmental issues in children. The research found no causal relationship between maternal genetic factors affecting birth weight and offspring neurodevelopment, although some evidence suggested that fetal genetic variants may play a limited role.

25 Oct 2023

Can your sleep predict depression? Insights from a genetic study

Researchers conducted a prospective study using a population-based cohort to calculate polygenic scores and understand whether suboptimal sleep durations indicated a predisposition to depression and vice versa.

24 Oct 2023

Decoding schizophrenia: insights and impacts from genetic discoveries

A recent study in Molecular Psychiatry delves into the genetic architecture of schizophrenia, uncovering insights into common and rare genetic variants, treatment resistance, and the evolutionary paradox of the disorder. This research highlights the complex nature of schizophrenia and the need for a transdiagnostic approach to psychiatric research.

22 Oct 2023

Wood cookstove use linked to gastric cancer risk

Researchers conducted a population-based study with a case–control design in rural areas of Honduras in Central America to examine whether wood cookstove use by indigenous populations was associated with increased risk of stomach cancers, including gastric adenocarcinoma.

4 Oct 2023

New multi-polygenic scores boost coronary heart disease prediction accuracy

Two multi-polygenic scores (muti-PGs) to predict coronary heart disease (CHD).

28 Sep 2023

Genetic link between migraines and breast cancer risk uncovered

Using Mendelian randomization analysis, the study finds a genetic link between migraine susceptibility and increased risk of overall and estrogen receptor-positive breast cancer. However, the findings suggest caution in interpretation, highlighting the need for further research to solidify these associations.

24 Sep 2023

Scientists uncover potential key risk factors for melanomas in children and adolescents

A recent eBioMedicine study found key risk factors associated with the development of melanoma in children and adolescents.

19 Sep 2023

New genetic test reveals a person’s predisposition to happiness

Your happiness levels aren't only based on external events. Genome testing can reveal how happy and optimistic you are predisposed to be. A leading testing expert reveals how variations of a key gene, CNR1, may have a significant impact on your level of happiness.

15 Sep 2023

How does the APOE4 gene play both hero and villain in your health risks?

The study reveals that APOE4, a genetic risk factor for Alzheimer's Disease and cardiovascular diseases, has complex effects on mortality risk. While APOE4 carriers with higher AD neuropathology have increased mortality risk, those with low neuropathology had a reduced risk of certain cancers, warranting further research into this genetic factor's diverse impact on health outcomes.

14 Sep 2023

Could your daily routine lead to dementia? New research points to sedentary lifestyle as potential risk factor

In a recent study, researchers investigated whether accelerometer-assessed sedentary behavior was associated with incident dementia.

13 Sep 2023

Unlocking the genetic code of blood sugar reveals new diabetes risks and lung complications

The study used a genome-wide association study (GWAS) to analyze random glucose levels in nearly half a million non-diabetic subjects, uncovering 150 distinct genetic signals, including 53 new ones, linked to glycemic traits and type 2 diabetes. The research also discovered a causal effect of random glucose and type 2 diabetes on lung function, identifying lung dysfunction as a new diabetes complication.

10 Sep 2023

Allele News and Research

Does the percentage of slow-wave sleep decline with aging, and are intra-individual declines associated with dementia risk?

How one gene shakes up our understanding of male infertility

Stopping metformin early linked to higher dementia risk in older adults with type 2 diabetes

Boosting brain health with iron and manganese: A dietary defense against cognitive decline

Study challenges link between low birth weight and childhood neurodevelopmental issues

Can your sleep predict depression? Insights from a genetic study

Decoding schizophrenia: insights and impacts from genetic discoveries

Wood cookstove use linked to gastric cancer risk

New multi-polygenic scores boost coronary heart disease prediction accuracy

Genetic link between migraines and breast cancer risk uncovered

Scientists uncover potential key risk factors for melanomas in children and adolescents

New genetic test reveals a person’s predisposition to happiness

How does the APOE4 gene play both hero and villain in your health risks?

Could your daily routine lead to dementia? New research points to sedentary lifestyle as potential risk factor

Unlocking the genetic code of blood sugar reveals new diabetes risks and lung complications

Breakthrough genome-wide study uncovers new loci impacting apolipoprotein E levels and Alzheimer's risk

Study reveals heart failure insights at single-cell level

Blood NfL levels correlate with severity of Alzheimer's disease pathology

Gene variant protects against Alzheimer's and Parkinson's diseases

Study finds that germline-encoded specificities cannot always predict the trajectory of B-cell responses

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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