Central Nervous System News and Research

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Breakthrough in gene editing: Enhanced virus-like particles promise new era in genetic disease treatment

Researchers developed an advanced prime editor-engineered virus-like particle (PE-eVLP) system, significantly enhancing gene editing efficiency in human cells and showing potential for treating genetic diseases.

9 Jan 2024

Infammasomes provide a therapeutic target against human diseases

The structure of inflammasomes and their role in diseases.

9 Jan 2024

Study finds Epstein-Barr virus T-cells prevalent in early multiple sclerosis

A study led by UTHealth Houston reveals that T-cells specific for Epstein-Barr virus-infected cells are highly present in the cerebrospinal fluid of people with early-stage multiple sclerosis, suggesting a link between EBV and the disease.

8 Jan 2024

Gut microbiota: the new frontier in Alzheimer’s disease research and therapy

The current evidence of the role of gut microbiota in Alzheimer’s disease (AD) pathogenesis.

8 Jan 2024

Breakthrough drug halts lung cancer and brain metastases

D'Or Institute for Research and Education (IDOR) played an important role in the phase III LIBRETTO-431 multicenter study, which evaluated the efficacy and safety of selpercatinib compared to control treatment, which consisted of platinum-based chemotherapy associated or not with pembrolizumab (immune checkpoint inhibitor) in non-small cell lung cancer (NSCLC).

5 Jan 2024

IDO2 deficiency in mice leads to behavioral abnormalities resembling autism spectrum disorder

Over the past decades, scientists have made substantial progress unveiling the underlying mechanisms behind many psychiatric disorders.

4 Jan 2024

Simple technique boosts antibody delivery for treating brain diseases

The blood-brain barrier blocks the entry of antibodies into the brain. This limits the potential use of antibody therapeutics to treat brain diseases, such as brain tumors.

3 Jan 2024

'Visual system' protein appears to be key for stabilizing the body's circadian rhythms

Scientists at the Johns Hopkins University School of Medicine and the National Institutes of Health have identified a protein in the visual system of mice that appears to be key for stabilizing the body's circadian rhythms by buffering the brain's response to light.

28 Dec 2023

Insilico Medicine develops new AI-generated FGFR2/3 inhibitor for tissue-agnostic solid tumors

Insilico Medicine ("Insilico"), a generative artificial intelligence (AI)-driven clinical-stage drug discovery company, today announced the nomination of ISM8001, a novel molecule targeting FGFR2/3 for the treatment of tissue-agnostic solid tumors bringing the total number of PCCs nominated in 2023 to six.

28 Dec 2023

Microglia found to play a key role in regulating the body's response to anesthesia

Though it may be a surprise to the millions of people who undergo general anesthesia every year for medical procedures, the biological mechanism for how different anesthetics block consciousness is still not fully understood.

22 Dec 2023

Monkey stem cells made easy: New method unveils xeno-free, efficient culture system

Non-human primates (NHPs) have a high degree of similarity to humans compared to other animal models.

22 Dec 2023

University of Michigan project seeks to improve control of robotic prosthetic legs

A smoother experience for robotic prosthetic leg users is the aim of a University of Michigan project that has received renewed support from the National Institutes of Health.

21 Dec 2023

OSU study pinpoints early muscle loss mechanism in acute spinal cord injury

Acute spinal cord injury (SCI) patients lose body weight and muscle mass, despite being on a high-calorie diet while in the intensive care unit.

20 Dec 2023

UW-Madison technology unveils autism gene's impact on early brain structure

Technology developed at the University of Wisconsin–Madison to grow "rosettes" of brain and spinal tissue gives scientists new ways to study the growing human brain, including a recent study of how genetic mutations linked to autism affect early stages of human brain development.

20 Dec 2023

Study reveals altered time perception in early Alzheimer's stages, offering potential early diagnostic marker

Study investigates time perception in Alzheimer's disease and its preclinical stage, subjective cognitive decline (SCD), revealing specific alterations in temporal processing that could be early markers of cognitive decline.

18 Dec 2023

Spinal cord stimulation restores sensation and eases phantom pain in amputees

Spinal cord stimulation can elicit sensation in the missing foot and alleviate phantom limb pain in people with lower limb amputations, University of Pittsburgh School of Medicine rehabilitation scientists report today.

14 Dec 2023

Study suggests possible targets for the development of a vaccine against multiple sclerosis

Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease in which the Epstein-Barr virus (EBV) is thought to play a role that has not yet been fully clarified.

14 Dec 2023

Revolutionizing diabetes care: tPBM therapy proves effective in restoring microglial health

Transcranial photobiomodulation (tPBM) treatment affected insulin therapy on microglial function.

12 Dec 2023

Coffee and caffeine boost metabolism and enhance exercise performance, study finds

Study reveals that coffee and caffeine enhance metabolism and exercise performance, showing varied effects on heart rate, energy expenditure, fat loss, and insulin sensitivity, with implications for athletes and general health.

11 Dec 2023

Novel molecular link between vitamin B12 and multiple sclerosis revealed in astrocytes

For decades, scientists have noted an intriguing similarity between a deficiency in vitamin B12 – an essential nutrient that supports healthy development and functioning of the central nervous system (CNS) – and multiple sclerosis (MS), a chronic disease in which the body's immune system attacks the CNS and which can produce neurodegeneration.