Immunodeficiency News and Research

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Immunodeficiency (or immune deficiency) is a state in which the immune system's ability to fight infectious disease is compromised or entirely absent.

New influenza vaccine strategies aim to enhance protection with T-cell responses

A recent review highlights the need for innovative influenza vaccines that combine T-cell and antibody responses to enhance protection across multiple strains and seasons.

6 May 2024

Differences in leading causes of disease burden between males and females

A recent study reveals that males bear a higher disease burden overall, while females experience a higher burden from seven specific conditions, emphasizing the need for tailored health interventions.

5 May 2024

Long-term impact of COVID-19 on body composition explored

COVID-19 may also affect body composition, even in those who did not acquire the infection.

5 May 2024

Machine learning tool can speed the diagnosis of undiagnosed patients with rare immune disorders

Researchers say a machine learning tool can identify many patients with rare, undiagnosed diseases years earlier, potentially improving outcomes and reducing cost and morbidity. The findings, led by researchers at UCLA Health, are described in Science Translational Medicine.

1 May 2024

New SARS-CoV-2 KP.2 variant defies vaccines with higher spread, study warns

Study on the bioRxiv server reports that the SARS-CoV-2 KP.2 variant, despite lower infectivity, shows significant immune resistance and higher transmissibility compared to other variants, potentially impacting global public health and vaccine efficacy.

29 Apr 2024

Immune dysfunction mechanism discovered in stroke and heart attack patients

Every year, between 250,000 and 300,000 people in Germany suffer from a stroke or heart attack.

23 Apr 2024

Understanding measles and the role of vaccination

With measles cases rising in Canada and internationally, it is important for clinicians to understand the disease and the role of vaccination against measles.

22 Apr 2024

Breast milk's secret weapon against RSV revealed in new study

Researchers explored how human milk oligosaccharides (HMOs) protect infants from respiratory syncytial virus (RSV), suggesting that these components in breast milk may prevent or reduce the severity of RSV infections through multiple mechanisms including gut microbiome modulation and direct antiviral actions.

15 Apr 2024

Unveiling the key role of RNA modification in HIV-1 survival and replication

A chemical modification in the HIV-1 RNA genome whose function has been a matter of scientific debate is now confirmed to be key to the virus's ability to survive and thrive after infecting host cells, a new study has found.

12 Apr 2024

Rethinking the germ theory: A balanced take on microbes and disease outcomes

Review explores the complexities of infectious disease outcomes through a balanced perspective, emphasizing the interplay between pathogenic microbes and host conditions, challenging the traditional germ-disease theory by proposing a more integrated view that considers both pathogen virulence and host immunity's impact on disease manifestation.

10 Apr 2024

Unraveling the complex web of rectal infections and the microbiome in MSM

Study delves into the relationships between various sexually transmitted infections, including Neisseria gonorrhoeae, Chlamydia trachomatis, Torquetenovirus, and high-risk HPV, and their effects on the anorectal microbiome among men who have sex with men (MSM), unveiling complex interactions that may influence infection outcomes and treatment strategies.

10 Apr 2024

Pioneering vaccine strategy promises to outmaneuver antimicrobial resistance

Study introduces Reverse Vaccine Development as a strategic approach to identify correlates of protection early in vaccine development against antimicrobial-resistant pathogens, aiming to mitigate risks such as significant phase-III clinical trial failures.

7 Apr 2024

New study finds interferon-γ release assays more effective than skin tests in predicting tuberculosis

The performance of tuberculin skin test (TST) and interferon-γ release assays (IGRAs) in predicting tuberculosis (TB).

5 Apr 2024

Breakthrough study offers hope for an effective HIV cure

By 2030, the World Health Organization (WHO), the Global Fund and UNAIDS are hoping to end the human immunodeficiency virus (HIV) and AIDS epidemic.

26 Mar 2024

Vitamin D shows promise in targeting aging's biological mechanisms, study finds

What is currently known about the potential effect of vitamin D (VitD) on modulating some hallmarks of aging.

26 Mar 2024

Global fight against TB misses 2020 WHO milestones, despite progress in certain age groups

The global, national, and regional burden and trends in tuberculosis.

26 Mar 2024

Empowering women through self-care: A leap towards health equity

The potential of self-care interventions to improve the health and well-being of girls and women to promote equity, gender equality, and human rights.

20 Mar 2024

COVID-19 pandemic reverses global life expectancy gains, reveals comprehensive study

The Lancet's study on global demographic trends from 1950 to 2021, incorporating COVID-19 data, highlights significant shifts in mortality, life expectancy, and the profound pandemic impact, emphasizing the need for updated health polici

13 Mar 2024

NIH study uncovers vulnerable sites on Epstein-Barr virus protein

Studies of interactions between two lab-generated monoclonal antibodies (mAbs) and an essential Epstein-Barr virus (EBV) protein have uncovered targets that could be exploited in designing treatments and vaccines for this extremely common virus.

12 Mar 2024

Breakthrough in CRISPR delivery promises safer gene editing

Recent research in PNAS highlights advancements in non-viral, cell-specific delivery methods for CRISPR-Cas systems, emphasizing their potential to enhance research and gene therapy applications by minimizing risks associated with off-target effects and improving targeted delivery.

7 Mar 2024