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Novel vaccine approach targets AML and other blood cancers

Acute myeloid leukemia (AML) is a type of blood cancer that forms in the soft marrow of the bones, typically attacking cells that would otherwise form the key component of the body's immunodefense system, white blood cells.

3 May 2024

Unlocking glioblastoma's immune suppression mechanism

The Wistar Institute assistant professor Filippo Veglia, Ph.D., and team, have discovered a key mechanism of how glioblastoma -; a serious and often fatal brain cancer -; suppresses the immune system so that the tumor can grow unimpeded by the body's defenses.

3 May 2024

Gyros Protein Technologies introduces Gyrolab Generic Rodent ADA Kit Reagents to support preclinical immunogenicity assessment

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From Gyros Protein Technologies AB 3 May 2024

Inulin fiber exacerbates inflammatory bowel disease, study finds

Inulin, a type of fiber found in certain plant-based foods and fiber supplements, causes inflammation in the gut and exacerbates inflammatory bowel disease in a preclinical model, according to a new study by Weill Cornell Medicine investigators.

2 May 2024

Study reveals how photobiomodulation improves cognitive alterations from chronic stress

Some neurological disorders can be improved through photobiomodulation, a non-invasive technique based on the application of low-intensity light to stimulate altered functions in specific regions of the body.

2 May 2024

Do flavonoids enhance cognitive function?

A recent study in Nutrients links flavonoid intake to improved cognitive function, though findings indicate further research is needed to understand its impact across diverse populations.

2 May 2024

New monoclonal antibody vaccine slashes malaria risk in children

A recent study demonstrates that the monoclonal antibody-based vaccine L9LS is safe for children aged 6 to 10 and significantly reduces the risk of malaria infection and clinical symptoms by 70% and 77%, respectively.

30 Apr 2024

U of T researchers develop new approach for controlling neuron generation in Parkinson's disease

Researchers at the University of Toronto have found a way to better control the preclinical generation of key neurons depleted in Parkinson's disease, pointing toward a new approach for a disease with no cure and few effective treatments.

30 Apr 2024

Genetic propensity to higher arachidonic acid levels linked to lower bipolar disorder risk

A genetic propensity to higher circulating levels of lipids containing arachidonic acid, an omega-6 polyunsaturated fatty acid found in eggs, poultry, and seafood, has been found to be linked with a lower risk for bipolar disorder, according to a new study in Biological Psychiatry, published by Elsevier.

30 Apr 2024

Genetic associations of key genes in breast cancer pathogenesis

Breast cancer remains a significant global health concern, warranting further exploration into its genetic basis and potential therapeutic targets.

29 Apr 2024

Parkinson’s UK invests £2.1 million in Neumora Therapeutics for preclinical testing of new Parkinson’s drug

Parkinson’s UK is investing £2.1million to support Neumora Therapeutics to carry out preclinical testing of NMRA-NLRP3, a NLRP3 inhibitor with the potential to reduce inflammation and protect brain cells in Parkinson’s. NLRP3 is a protein that plays a role in regulating a number of inflammatory processes that are believed to contribute to the damage to brain cells that underlies Parkinson’s.

27 Apr 2024

Study reveals surprising role of maternal cytokines in offspring psychiatric risk

Researchers at Weill Cornell Medicine have discovered in a preclinical model that cytokines, proteins that control immune response, circulating in maternal blood during pregnancy may mitigate an offspring's risk for psychiatric conditions.

25 Apr 2024

Synthetic nanomaterial could be an effective tool for treating neurodegenerative diseases

A newly developed nanomaterial that mimics the behavior of proteins could be an effective tool for treating Alzheimer's and other neurodegenerative diseases.

25 Apr 2024

Insilico Medicine's AI-designed drug ISM3412 receives FDA IND approval

Clinical stage artificial intelligence (AI)-driven drug discovery company Insilico Medicine announces that it has received approval from the U.S. Food and Drug Administration for its Investigational New Drug application for ISM3412, a small molecule inhibitor of MAT2A for the potential treatment of MTAP deleted cancers designed with Insilico's generative AI platform.

25 Apr 2024

Preclinical News and Research

Novel vaccine approach targets AML and other blood cancers

Unlocking glioblastoma's immune suppression mechanism

Gyros Protein Technologies introduces Gyrolab Generic Rodent ADA Kit Reagents to support preclinical immunogenicity assessment

Inulin fiber exacerbates inflammatory bowel disease, study finds

Study reveals how photobiomodulation improves cognitive alterations from chronic stress

Do flavonoids enhance cognitive function?

New monoclonal antibody vaccine slashes malaria risk in children

U of T researchers develop new approach for controlling neuron generation in Parkinson's disease

Genetic propensity to higher arachidonic acid levels linked to lower bipolar disorder risk

Genetic associations of key genes in breast cancer pathogenesis

Parkinson’s UK invests £2.1 million in Neumora Therapeutics for preclinical testing of new Parkinson’s drug

Study reveals surprising role of maternal cytokines in offspring psychiatric risk

Synthetic nanomaterial could be an effective tool for treating neurodegenerative diseases

Insilico Medicine's AI-designed drug ISM3412 receives FDA IND approval

Therapeutic potential of human umbilical cord-derived mesenchymal stem cells in Crohn’s disease

MSU team creates a promising vaccine candidate for antibiotic-resistant bacteria

Innovative malaria prodrug targets liver, enhances efficacy while reducing toxicity, preclinical studies show

CN Bio raises $21 million USD in first close of Series B investment round

Research explores how moms' obesity reprograms babies

New tool hunts for Alzheimer's clues in gut microbiome

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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