Drug Discovery & Pharmaceuticals

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Moffitt researchers develop novel reagent for efficient synthesis of sulfur-containing drug candidates

During the past decade, there has been significant development of new sulfur containing compounds that are used in various industries, including pharmaceuticals and agricultural products.

22 Jan 2024

AI scores breakthrough in anemia treatment with novel PHD inhibitor

Clinical stage generative artificial intelligence (AI)-driven biotechnology company InSilico Medicine ("InSilico"), today announced that the Journal of Medicinal Chemistry, an ACS Publications journal focusing on critical studies about molecular structure and biological activity, has published the company's discovery of a novel PHD inhibitor for the treatment of anemia.

19 Jan 2024

Insilico Medicine leverages AI to identify promising new target for breast and gynecological cancers

Insilico Medicine("Insilico"), a clinical stage generative artificial intelligence (AI)-driven drug discovery company, recently published an early research that it has identified MYT1 as a promising new therapeutic target for breast and gynecological cancer, and discovered a series of novel, potent, and highly selective inhibitors specifically targeting MYT1.

19 Jan 2024

Conscience's open science competition yields hits for new Parkinson's drugs

As part of its pioneering approach to drug discovery, the Canadian nonprofit Conscience announced today that its first open science competition has resulted in the identification of seven promising molecules, or "hits," that show potential for new, more effective drugs for familial Parkinson's disease.

16 Jan 2024

New analysis of cancer cells identifies 370 targets for smarter, personalized treatments

A new, systematic analysis of cancer cells identifies 370 candidate priority drug targets across 27 cancer types, including breast, lung and ovarian cancers.

13 Jan 2024

New compound effective against bacterial species resistant to multiple classes of existing antibiotics

Recent studies by Zampaloni et al. and Pahil et al. published in the journal Nature describe a novel method of inhibiting the growth of Gram-negative bacteria such as Acinetobacter using antibiotics consisting of macrocyclic peptides that target the bacterial protein bridge machinery that transports lipopolysaccharides from the cytoplasm to the outer membrane.

4 Jan 2024

New synthetic antibiotic found to be more effective than established drugs against 'superbugs'

A new synthetic antibiotic developed by University of Liverpool researchers is shown to be more effective than established drugs against 'superbugs' such as MRSA, a new study shows.

3 Jan 2024

Scripps scientists develop powerful method to find drug targets in live cells

Identifying new ways to target proteins involved in human diseases is a priority for many researchers around the world.

2 Jan 2024

Insilico Medicine develops new AI-generated FGFR2/3 inhibitor for tissue-agnostic solid tumors

Insilico Medicine ("Insilico"), a generative artificial intelligence (AI)-driven clinical-stage drug discovery company, today announced the nomination of ISM8001, a novel molecule targeting FGFR2/3 for the treatment of tissue-agnostic solid tumors bringing the total number of PCCs nominated in 2023 to six.

28 Dec 2023

New method designs high-affinity, orally bioavailable peptides

For decades, a substantial number of proteins, vital for treating various diseases, have remained elusive to oral drug therapy.

28 Dec 2023

Degron Therapeutics announced as winner of AFCR's 2023 BRACE Award Venture Competition

The Asian Fund for Cancer Research (AFCR) is pleased to announce that Degron Therapeutics was selected as the winner of the 2023 BRACE Award Venture Competition.

27 Dec 2023

Researchers receive two grants to study tuberculosis drug development

Weill Cornell Medicine researchers and the TB Drug Accelerator have received two grants totaling $6.8 million from the Bill & Melinda Gates Foundation to study tuberculosis (TB) drug development.

26 Dec 2023

First new antibiotic class in decades discovered using explainable AI platform

Scientists have discovered one of the first new classes of antibiotics identified in the past 60 years, and the first discovered leveraging an AI-powered platform built around explainable deep learning.

20 Dec 2023

Mice with humanized immune systems test new cancer therapeutic approach that blindfolds immune cells to the body’s self-recognition system

Researchers investigated the anticancer effects of drugs targeting human tumor-associated macrophages (TAMs) in vivo. In humanized murine models, they tested the effectiveness of an antibody to human signal regulatory protein alpha (SIRPα) for cancer immunotherapy.

19 Dec 2023

Drug Discovery & Pharmaceuticals

Moffitt researchers develop novel reagent for efficient synthesis of sulfur-containing drug candidates

AI scores breakthrough in anemia treatment with novel PHD inhibitor

Insilico Medicine leverages AI to identify promising new target for breast and gynecological cancers

Conscience's open science competition yields hits for new Parkinson's drugs

New analysis of cancer cells identifies 370 targets for smarter, personalized treatments

New compound effective against bacterial species resistant to multiple classes of existing antibiotics

New synthetic antibiotic found to be more effective than established drugs against 'superbugs'

Scripps scientists develop powerful method to find drug targets in live cells

Insilico Medicine develops new AI-generated FGFR2/3 inhibitor for tissue-agnostic solid tumors

New method designs high-affinity, orally bioavailable peptides

Degron Therapeutics announced as winner of AFCR's 2023 BRACE Award Venture Competition

Researchers receive two grants to study tuberculosis drug development

First new antibiotic class in decades discovered using explainable AI platform

Mice with humanized immune systems test new cancer therapeutic approach that blindfolds immune cells to the body’s self-recognition system

Scientists crack the code for targeting cancer's 'death star' protein

Deep learning designs high-affinity protein binders for bioactive helical peptides

New discovery could expand the possibilities for medical use of Botox

Expanding the toolbox for drug design: New enzymes for tailoring molecules

A step forward in vaccine technology: Exploring the effects of N1-methylpseudouridine in mRNA translation

Design modifications offer promise for safer and more effective mRNA therapeutics

Discover how SciY empowers scientists

Why use light scattering to analyze proteins and viral vectors?

Changing the landscape of R&D to build clinical success from the ground up

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