Leukemia News and Research

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Leukemia (Leukaemia) is a cancer of the blood cells. It is the most common type of blood cancer and affects 10 times as many adults as children. Most people diagnosed with leukemia are over 50 years old. No one knows why some people develop leukemia and others do not. However, scientists have identified some risk factors for the disease. Most people who have known risk factors do not get leukemia, while many who do get the disease have none of these risk factors. During the early stages of leukemia, there may be no symptoms. Many of the symptoms of leukemia don't become apparent until a large number of normal blood cells are crowded out by leukemia cells.

New armored CAR T cell therapy boosts response in Relapsed non-Hodgkin lymphoma patients

While CAR T cell therapy has revolutionized treatment for many blood cancers, including non-Hodgkin lymphoma (NHL), many patients who receive CAR T cell therapy do not experience a long-term remission.

13 Jun 2024

MEK inhibitor trametinib shows potential in pediatric JMML treatment

The MEK inhibitor trametinib (Mekinist) was an effective treatment for pediatric patients with relapsed or refractory juvenile myelomonocytic leukemia (JMML) enrolled in a phase II clinical trial, with seven of 10 patients alive after a median of two years.

13 Jun 2024

Stanford study finds low risk of secondary blood cancers after CAR-T cell therapy

A large study by researchers at Stanford Medicine has found that the risk of secondary blood cancers after CAR-T cell therapy -; a cell-based cancer treatment that exploded on the scene in 2017 as a treatment for intractable blood cancers -; is low, despite a Food and Drug Administration warning.

12 Jun 2024

Study identifies genetic predictors of X chromosome loss in aging women

Researchers have identified inherited genetic variants that may predict the loss of one copy of a woman's two X chromosomes as she ages, a phenomenon known as mosaic loss of chromosome X, or mLOX.

12 Jun 2024

UCLA researchers discover key protein regulating blood stem cell self-renewal

UCLA scientists have identified a protein that plays a critical role in regulating human blood stem cell self-renewal by helping them sense and interpret signals from their environment.

5 Jun 2024

Common anti-inflammatory drug could combat deadly gut fungus, study finds

A team of UC Davis Health researchers discovered that a common anti-inflammatory drug, mesalamine, can replace the work of good bacteria in fighting the nasty fungus Candida albicans in the gut.

4 Jun 2024

Blocking CDK7 protein could prevent heart damage associated with cancer treatment

Blocking a protein known as CDK7 could prevent heart damage associated with a commonly used cancer chemotherapy medication, according to a study led by scientists at Washington State University.

4 Jun 2024

Experimental treatment for metastatic pancreatic cancer shows promise in phase 2 clinical trial

Clinicians at Georgetown University's Lombardi Comprehensive Cancer Center reported promising preliminary findings based on outcomes in the first six patients with metastatic pancreatic cancer enrolled in a phase 2 clinical trial of the experimental drug BXCL701 in combination with the immunotherapy drug pembrolizumab (Keytruda).

3 Jun 2024

Breakthrough CAR T therapy and shorter targeted therapy durations offer hope for patients with leukemia

The novel anti-CD19 autologous chimeric antigen receptor (CAR) T cell therapy obecabtagene autoleucel (obe-cel) achieved durable remissions in 40% of patients with relapsed or refractory B-ALL without a subsequent stem cell transplant (SCT), according to results from the Phase Ib/II FELIX clinical trial presented today by Elias Jabbour, M.D., professor of Leukemia.

31 May 2024

Genomic evidence of prenatal origins in childhood acute myeloid leukemia

A team of researchers from the Institute of Oncology of the University of Oviedo (IUOPA), the Josep Carreras leukemia Research Institute, the University of Barcelona and the Centre for Biomedical Research in Cancer Network (CIBERONC) have demonstrated that some childhood leukemia originate during embryonic development, although they do not manifest after a few months after birth.

30 May 2024

Transportation of cancer nanomedicines into solid tumors

A new study conducted by the Wilhelm Lab at the University of Oklahoma examines a promising development in biomedical nanoengineering.

20 May 2024

Comprehensive cost and utilization of commercial CAR-T therapy in pediatric B-ALL patients

A new editorial paper was published in Oncoscience (Volume 11) on April 25, 2024, entitled, "The price of hope: CAR-T therapy in pediatric leukemia."

17 May 2024

Metformin use linked to reduced risk of myeloproliferative neoplasms

People who use metformin are less likely to develop a myeloproliferative neoplasm (MPN) over time, indicating that the treatment may help prevent the development of certain types of cancers, according to a study published in Blood Advances.

17 May 2024

Proteins in the blood could warn people of cancer more than seven years before it is diagnosed

Researchers from the UK investigated associations between 1,463 plasma proteins and 19 cancers, using observational and genetic approaches in participants of the UK Biobank.

17 May 2024

AML patients at the extremes of older age derive benefit from VEN-HMA regimen

Standard of care treatment for acute myeloid leukemia (AML) is safe and effective for adults over 80, according to a study published in Blood Neoplasia. For roughly a quarter of patients, this treatment can durably prolong survival.

9 May 2024

Researchers enhance CAR-T cells to target solid tumors

Researchers at the National Cancer Institute-designated Montefiore Einstein Comprehensive Cancer Center (MECCC) have shown that a breakthrough therapy for treating blood cancers can be adapted to treat solid tumors-;an advance that could transform cancer treatment.

8 May 2024

Leukemia News and Research

Further Reading

New armored CAR T cell therapy boosts response in Relapsed non-Hodgkin lymphoma patients

MEK inhibitor trametinib shows potential in pediatric JMML treatment

Stanford study finds low risk of secondary blood cancers after CAR-T cell therapy

Study identifies genetic predictors of X chromosome loss in aging women

UCLA researchers discover key protein regulating blood stem cell self-renewal

Common anti-inflammatory drug could combat deadly gut fungus, study finds

Blocking CDK7 protein could prevent heart damage associated with cancer treatment

Experimental treatment for metastatic pancreatic cancer shows promise in phase 2 clinical trial

Breakthrough CAR T therapy and shorter targeted therapy durations offer hope for patients with leukemia

Genomic evidence of prenatal origins in childhood acute myeloid leukemia

Transportation of cancer nanomedicines into solid tumors

Comprehensive cost and utilization of commercial CAR-T therapy in pediatric B-ALL patients

Metformin use linked to reduced risk of myeloproliferative neoplasms

Proteins in the blood could warn people of cancer more than seven years before it is diagnosed

AML patients at the extremes of older age derive benefit from VEN-HMA regimen

Researchers enhance CAR-T cells to target solid tumors

Medically aided conception vs. natural conception: Study explores cancer risk in children

Novel vaccine approach targets AML and other blood cancers

Toxic gas adds to a long history of pollution in Southwest Memphis

Urine-based test developed for early detection of head and neck tumors

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