Lymph Node News and Research

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Lymph is clear or white fluid that travels through vessels, moves within tissues and work to keep all the parts of the body clean. After passing through the channels of the lymphatic system they drain into the lymph nodes. The lymph nodes act as filters along the lymphatic system. These nodes trap germs like bacteria, viruses, toxins as well as cancer cells and ensure that these are removed from the body.

Enhancing CAR-T cell therapy with biodegradable scaffolds

CAR-T cell therapies are transforming the treatment of previously incurable blood cancers. Six approved CAR-T products have been administered to more than 20,000 people, and more than 500 clinical trials are underway.

12 Jun 2024

Innovative FAP-targeted radioligand therapy controls disease progression in sarcoma

Fibroblast activation protein (FAP)-targeted radioligand therapy is safe and effective for treating patients with progressive metastatic tumors, specifically advanced sarcomas, according to research presented at the 2024 Society of Nuclear Medicine and Molecular Imaging Annual Meeting.

10 Jun 2024

‘Artificial lymph node’ shows potential to treat cancer

Johns Hopkins Medicine scientists say they have developed an artificial lymph node with the potential to treat cancer, according to a new study in mice and human cells.

6 Jun 2024

Novel PET radiotracer enables same-day imaging of gastrointestinal cancer biomarker

A new PET radiotracer enables same-day imaging of the important gastrointestinal cancer biomarker known as Claudin18.2 (CLDN18.2).

6 Jun 2024

New treatment approach could offer longer lasting protection to people with breast cancer

Killing breast cancer cells in a way that trains the immune system to recognize and destroy residual cancer cells could offer longer lasting protection to people with the disease, according to new research funded by Breast Cancer Now.

3 Jun 2024

New study advocates for de-escalating breast cancer surgery in women aged 55 and older

Surgery involving sentinel lymph node biopsy for middle-aged women with estrogen receptor-positive (ER+) breast cancer may do more harm than good, according to a new study led by University of Pittsburgh and UPMC Hillman Cancer Center researchers.

22 May 2024

Oncotype DX Breast Recurrence Score test recommended by NICE for lymph node-positive breast cancer patients

Exact Sciences, a leading provider of cancer screening and diagnostic tests, today announced that the UK’s National Institute for Health and Care Excellence (NICE) has recommended the expanded use of the Oncotype DX Breast Recurrence Score® test to more effectively target chemotherapy treatment for women who have hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-), early-stage breast cancer involving up to three positive nodes and who have been through the menopause.

15 May 2024

New Quartet nanocage vaccine shows promise against coronavirus variants

Researchers have developed a novel vaccination approach using Quartet nanocages that display receptor-binding domains (RBDs) from different sarbecoviruses, showing enhanced immune responses and potential protection against diverse coronavirus strains including SARS-CoV-2 and its variants.

8 May 2024

Durable lymph-node expansion improves vaccine responses against tumors

Each one of us has around 600 lymph nodes (LNs) – small, bean-shaped organs that house various types of blood cells and filter lymph fluid – scattered throughout our bodies.

6 May 2024

Evaluating ChatGPT for structured data extraction from clinical notes

Researchers evaluate the ability of ChatGPT to extract structured data from unstructured clinical notes.

5 May 2024

Avian flu crosses species, infecting cats and cattle in Texas and Kansas

A study in the CDC's Emerging Infectious Disease Journal reports the spread of H5N1 avian influenza among cats and dairy cattle in Texas and Kansas, showing systemic illness in cattle and significant fatalities in cats exposed to the virus through infected milk.

1 May 2024

Minimally invasive techniques fight colorectal cancer precursors

Colorectal cancer (CRC) is the second most common cancer in the United States. This highlights the importance of early detection and treatment of precancerous lesions like large polyps. Endoscopy offers a minimally invasive approach to removing these polyps, reducing the need for traditional surgery.

23 Apr 2024

Combined chemohormonal therapy for locally advanced prostate cancer offers extended control of PSA levels

For patients with locally advanced prostate cancer, combined treatment with chemotherapy and hormonal therapy offers extended control of prostate-specific antigen (PSA) levels, compared to hormonal therapy alone, reports a study in the April issue of The Journal of Urology, an Official Journal of the American Urological Association.

17 Apr 2024

Tumor microbiomes offer new insights for enhancing cancer therapies

Comprehensive review reveals the significant impact of tumor-resident bacteria on metastatic cancer, showing how microbiome genomes influence tumor biology, immune system response, and treatment effectiveness. It lays the groundwork for utilizing bacteria-focused therapies to complement traditional cancer treatments.

11 Apr 2024

Innovative breast cancer treatment sequence yields positive results

Researchers at The University of Texas MD Anderson Cancer Center showed that altering the sequence of breast cancer treatment to administer radiation before mastectomy allowed for concurrent breast reconstruction surgery, which reduced the number of operations required, minimized treatment delays and improved patient satisfaction.

5 Apr 2024

miR-205 knockout surprises with enhanced mammary development and cancer insights

New research unveils the paradoxical role of miR-205 in mammary gland development and its potential impact on breast cancer, highlighting the miRNA's complex involvement in stem cell regulation and tumor suppression.

2 Apr 2024

Microwave ablation offers a promising treatment option for multifocal papillary thyroid cancer

In a 10-center study, microwave ablation offered progression free survival rates and fewer complications than surgery in the treatment of a form of thyroid cancer known as papillary thyroid carcinoma (PTC), according to research published today in Radiology, a journal of the Radiological Society of North America.

2 Apr 2024

Study reveals immune cell levels as prognostic marker in early-stage triple-negative breast cancer

A new multicenter, international study suggests that people who have early-stage triple-negative breast cancer (TNBC) and high levels of immune cells within their tumors may have a lower risk of recurrence and better survival rates even when not treated with chemotherapy.

2 Apr 2024

Study shows the enduring impact of historical redlining on colon cancer care

A nationwide study of 196 cities shows that housing discrimination from 90 years ago still casts a historical shadow of inequities in colon cancer care today, S.M. Qasim Hussaini, M.D., of the University of Alabama at Birmingham and colleagues at the American Cancer Society and Johns Hopkins School of Public Health report in the journal JCO Oncology Practice.

28 Mar 2024

Vitamin D receptor presence in breast cancer tumors linked to better survival outcomes

Research identifies vitamin D receptors (VDR) in breast cancer tumors as a promising prognostic marker, linking VDR presence to tumor characteristics, survival outcomes, and potentially informing treatment strategies.

25 Mar 2024

Lymph Node News and Research

Further Reading

Enhancing CAR-T cell therapy with biodegradable scaffolds

Innovative FAP-targeted radioligand therapy controls disease progression in sarcoma

‘Artificial lymph node’ shows potential to treat cancer

Novel PET radiotracer enables same-day imaging of gastrointestinal cancer biomarker

New treatment approach could offer longer lasting protection to people with breast cancer

New study advocates for de-escalating breast cancer surgery in women aged 55 and older

Oncotype DX Breast Recurrence Score test recommended by NICE for lymph node-positive breast cancer patients

New Quartet nanocage vaccine shows promise against coronavirus variants

Durable lymph-node expansion improves vaccine responses against tumors

Evaluating ChatGPT for structured data extraction from clinical notes

Avian flu crosses species, infecting cats and cattle in Texas and Kansas

Minimally invasive techniques fight colorectal cancer precursors

Combined chemohormonal therapy for locally advanced prostate cancer offers extended control of PSA levels

Tumor microbiomes offer new insights for enhancing cancer therapies

Innovative breast cancer treatment sequence yields positive results

miR-205 knockout surprises with enhanced mammary development and cancer insights

Microwave ablation offers a promising treatment option for multifocal papillary thyroid cancer

Study reveals immune cell levels as prognostic marker in early-stage triple-negative breast cancer

Study shows the enduring impact of historical redlining on colon cancer care

Vitamin D receptor presence in breast cancer tumors linked to better survival outcomes

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