Ligand News and Research

RSS

Researchers discover diverse and spatially coordinated cardiac cells involved in heart development

Researchers use a combination of scRNA-seq and multiplexed error-robust fluorescence in situ hybridization to better understand cardiac cell types.

13 Mar 2024

LAG-3 protein structure may be the key to unlocking new cancer treatments

A molecular “snapshot” of a protein can be critical to understanding its function. Scientists at Stanford and NYU have published and investigated a new structure of the protein LAG-3 which could enable the development of new cancer treatments.

11 Mar 2024

Gut bacteria strains could be the key to predicting cancer treatment success

Researchers discovered that gut microbiota strains can predict the effectiveness and adverse effects of immune checkpoint blockade (ICB) therapy in rare cancer patients.

6 Mar 2024

Revolutionary tool for tracking physical interactions between different cells

One of the fundamental goals of basic biology is understanding how diverse cell types work in concert to form tissues, organs, and organ systems.

6 Mar 2024

Comprehensive analysis of immune checkpoint inhibitors reveals endocrine toxicity patterns

Announcing a new publication for Acta Materia Medica journal. Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment but pose a challenge of immune-related adverse events (irAEs), particularly endocrine toxicity, that can severely compromise patient well-being.

21 Feb 2024

Novel splicing mechanism for short introns discovered

Researchers confirm that the established pre-mRNA splicing mechanism that appears in textbooks cannot work in a subset of human short introns: A novel SAP30BP–RBM17 complex-dependent splicing has been uncovered.

15 Feb 2024

Researchers discover new mechanism of action between the nutrient adaptation of intestinal stem cells and aging

Researchers used an organ-wide approach to quantitatively analyze cell number, size, and identity regulation upon nutrient-induced tissue adaptation of the Drosophila midgut.

15 Feb 2024

Combo of targeted and immunotherapy may boost NSCLC treatment by overcoming immune resistance and enhancing anti-tumor activity

Researchers evaluated rational combination treatment regimens for advanced/metastatic non-small-cell lung cancer (NSCLC).

15 Feb 2024

Smoking, infection, and BMI found to significantly sway immune response, study shows

Study reveals how smoking, CMV latent infection, and BMI significantly influence cytokine release, impacting immune response variability and potentially affecting disease risk.

14 Feb 2024

Study finds interleukin-24 enhances CAR-T cell therapy's effectiveness against cancer stem cells

The effect of Interleukin-24 (IL-24) on CSCs and CAR-T cell therapy.

14 Feb 2024

Never-before-documented genetic disorder causes rare lung disease

The macrophage is one of the body's most important inhabitants. Meaning "big eater" in Greek, this immune cell consumes and digests problematic elements from microbes and cancer cells to dust and debris.

8 Feb 2024

SARS-CoV-2 fragments found to mimic immune system peptides, fueling inflammation

Study reveals SARS-CoV-2 fragments mimic immune peptides, potentially driving the virus's inflammatory response, offering insights into COVID-19's severe inflammation mechanisms.

5 Feb 2024

New approach to treating neuropathic pain offers the possibility of non-opioid pain relief for millions

Researchers investigated the selective activity of sigmoid 2 receptor (σ2R) or transmembrane protein 97 (TMEM97) ligands on murine neuropathic pain models, their effects on nociceptive neurons and the mechanism of action after 24 hours.

5 Feb 2024

Study sheds light on 7-DHC's potential to induce cell death-resistant state in tumors

Cell death is fundamental to life and, thus, healthy aging. In the realm of cellular biology, ferroptosis (a form of programmed cell death) has emerged not only as a focal point of research for its potential in eliminating cancer cells, but also its role in a plethora of other diseases, including neurodegenerative diseases such as Alzheimer's disease, eye diseases such as Retinitis pigmentosa and age-related macular degeneration, as well as ischemia, cardiovascular disease, liver disease, acute kidney injury and inflammation.

1 Feb 2024

Ligand News and Research

Researchers discover diverse and spatially coordinated cardiac cells involved in heart development

LAG-3 protein structure may be the key to unlocking new cancer treatments

Gut bacteria strains could be the key to predicting cancer treatment success

Revolutionary tool for tracking physical interactions between different cells

Comprehensive analysis of immune checkpoint inhibitors reveals endocrine toxicity patterns

Novel splicing mechanism for short introns discovered

Researchers discover new mechanism of action between the nutrient adaptation of intestinal stem cells and aging

Combo of targeted and immunotherapy may boost NSCLC treatment by overcoming immune resistance and enhancing anti-tumor activity

Smoking, infection, and BMI found to significantly sway immune response, study shows

Study finds interleukin-24 enhances CAR-T cell therapy's effectiveness against cancer stem cells

Never-before-documented genetic disorder causes rare lung disease

SARS-CoV-2 fragments found to mimic immune system peptides, fueling inflammation

New approach to treating neuropathic pain offers the possibility of non-opioid pain relief for millions

Study sheds light on 7-DHC's potential to induce cell death-resistant state in tumors

CRISPR revolutionized: New method edits genes directly in the body

Is there an association between vitamin D, immunocompetence, and aging?

Researchers discover non-opioid therapeutic for relieving neuropathic pain

Lung cancer prediction using biomarkers based on bronchoalveolar fluid microbiomes

Study shows Omicron variants evade immune system like predecessors, suggesting key evolutionary trait in SARS-CoV-2

GRK2: A new target for inhibiting macrophage infiltration and angiogenesis in rheumatoid arthritis

Revolutionizing Life Science: An Interview with SCIEX on ASMS, the SCIEX 7500+ System, and AI-Driven Quantitation

From Discovery Biology to ELRIG Chair

Breathing New Life into Diagnostics: Plasmion's SICRIT Technology

Latest News