Alzheimer's Disease News and Research

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Alzheimer's disease (AD) is an irreversible, progressive brain disease that slowly destroys memory and thinking skills and, eventually, the ability to carry out the simplest tasks of daily living. In most people with AD, symptoms first appear after age 60. AD is the most common cause of dementia among older people, but it is not a normal part of aging. Dementia refers to a decline in cognitive function that interferes with daily life and activities. AD starts in a region of the brain that affects recent memory, then gradually spreads to other parts of the brain. Although treatment can slow the progression of AD and help manage its symptoms in some people, currently there is no cure for this devastating disease.

Blood-based biomarkers could revolutionize Alzheimer's diagnosis and treatment

A recent review outlines the necessary factors for widespread implementation and interpretation of Alzheimer's disease blood-based biomarkers (BBMs) at the population level, emphasizing the potential for early detection and improved diagnosis.

14 Jun 2024

MIT researchers develop revolutionary system for high-resolution brain imaging

A suite of three innovations by an MIT-based team enables high-resolution, high-throughput imaging of human brain tissue at a full range of scales and mapping connectivity of neurons at single cell resolution.

13 Jun 2024

Revolutionary platform unveils detailed human brain architecture at multiple scales

A new platform enables simultaneous capture of protein expression, cellular morphology, neural projection, and synapse distribution in large-scale human brain tissues at multiple scales, researchers report.

13 Jun 2024

Study links balanced neural activity to enhanced cognitive abilities in youth

In a world where external and internal stimuli can throw our entire body system off balance, how does our brain prevent itself from becoming overly stimulated?

13 Jun 2024

Combining donepezil and memantine extends lives of Alzheimer's patients, study finds

Alzheimer's disease is the world's most common neurodegenerative disease, affecting more than 50 million people globally.

12 Jun 2024

Study identifies drug target to prevent autonomic dysfunction after spinal cord injury

In response to stressful or dangerous stimuli, nerve cells in the spinal cord activate involuntary, autonomic reflexes often referred to as "fight or flight" responses.

12 Jun 2024

Prolonged depression in young adults linked to cognitive decline in middle age

People who experience prolonged depressive symptoms starting in young adulthood may have worse thinking and memory skills in middle age, according to a study published in the June 12, 2024, online issue of Neurology, the medical journal of the American Academy of Neurology.

12 Jun 2024

Integration of genomics, epigenomics, and transcriptomics in understanding Alzheimer's pathogenesis

With the advent of new omics technologies in recent years, there has been a deluge of complex, high-dimensional data on Alzheimer's disease (AD).

12 Jun 2024

New AARF-D award supports Temple researchers to explore synapse function in the aging brain

Late-life depression is a major risk factor for Alzheimer's disease, in particular because it accelerates progression from mild cognitive impairment to dementia.

12 Jun 2024

Long-read RNA sequencing reveals novel insights into alternative splicing and disease genetics

Tokyo Medical and Dental University (TMDU) researchers harness long-read RNA sequencing to decode genetic intricacies and disease links.

12 Jun 2024

Few UK Alzheimer's patients suitable for new disease-modifying drugs, study finds

Few people in the UK with early stage Alzheimer's disease are likely to be suitable for the latest drugs which aim to halt progress of the condition, yet many are nevertheless likely to be referred for these treatments, finds research published online in the Journal of Neurology Neurosurgery & Psychiatry.

11 Jun 2024

Patient perspectives highlight urgent need for research on smell and taste disorders

Researchers and patient advocates from the Monell Chemical Senses Center, Smell and Taste Association of North America (STANA), and Thomas Jefferson University came together during the COVID-19 pandemic to incorporate patient voices in efforts to prioritize research areas focused on improving care for people with smell and taste disorders.

10 Jun 2024

Johns Hopkins researchers discover how epilepsy drug modulates brain activity

By super cooling a molecule on the surface of brain cells down to about minus 180 degrees Celsius -; nearly twice as cold as the coldest places in Antarctica -; scientists at Johns Hopkins Medicine say they have determined how a widely-used epilepsy drug works to dampen the excitability of brain cells and help to control, although not cure, seizures.

10 Jun 2024

Transplanted gut microbes from aged mice trigger inflammation in young germ-free mice

When scientists transplanted the gut microbes of aged mice into young "germ-free" mice -; raised to have no gut microbes of their own -; the recipient mice experienced an increase in inflammation that parallels inflammatory processes associated with aging in humans.

10 Jun 2024

New brain connectivity model predicts dementia years before diagnosis

Whether the default-mode network (DMN) effective connectivity can predict future dementia diagnosis at the individual level.

10 Jun 2024

Surprising link between a diverse oral microbiome and better cognitive function in aging

Study found that higher oral microbiome diversity is linked to better cognitive function and fewer memory issues in older US adults, highlighting the "oral-brain axis."

9 Jun 2024

Changes in exploration behavior suggest early signs of cognitive decline in middle age

Spatial navigation – the ability to select and follow a route from one place to another – is a skill we use every day. Depending on practice, general cognitive ability, and childhood environment, some people are naturally better at this than others. But research has also shown that people’s skill in spatial navigation tends to decrease with increasing age.

8 Jun 2024

Alzheimer's Disease News and Research

Further Reading

Blood-based biomarkers could revolutionize Alzheimer's diagnosis and treatment

MIT researchers develop revolutionary system for high-resolution brain imaging

Revolutionary platform unveils detailed human brain architecture at multiple scales

Study links balanced neural activity to enhanced cognitive abilities in youth

Combining donepezil and memantine extends lives of Alzheimer's patients, study finds

Study identifies drug target to prevent autonomic dysfunction after spinal cord injury

Prolonged depression in young adults linked to cognitive decline in middle age

Integration of genomics, epigenomics, and transcriptomics in understanding Alzheimer's pathogenesis

New AARF-D award supports Temple researchers to explore synapse function in the aging brain

Long-read RNA sequencing reveals novel insights into alternative splicing and disease genetics

Few UK Alzheimer's patients suitable for new disease-modifying drugs, study finds

Patient perspectives highlight urgent need for research on smell and taste disorders

Johns Hopkins researchers discover how epilepsy drug modulates brain activity

Transplanted gut microbes from aged mice trigger inflammation in young germ-free mice

New brain connectivity model predicts dementia years before diagnosis

Surprising link between a diverse oral microbiome and better cognitive function in aging

Changes in exploration behavior suggest early signs of cognitive decline in middle age

Developing pre-symptomatic diagnostic tools for Alzheimer's disease using long-read RNA sequencing

Ohio State creates user-friendly repository to help study Alzheimer's disease

New method provides a more accurate way to predict dementia up to nine years before diagnosis

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