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Single infusion of engineered T-cells achieves lasting asthma remission in mice

Researchers demostrate that durable asthma remission can be achieved with engineered and long-lived CAR T-cell treatment in mice.

31 May 2024

Researchers uncover two classes of genetic causes for pediatric chordoma

Little is known about the genetics and biology of chordoma, a rare and aggressive bone tumor. Chordomas occur in approximately one in a million people in the U.S. a year and only five percent of these are in children.

30 May 2024

Unveiling the epigenetic impact of prenatal amphetamine exposure using C. elegans models

Amphetamine is a psychostimulant that has been used to treat a variety of brain dysfunctions. However, it is a highly abused drug.

30 May 2024

How tight binding between immune cells dictates T cell cancer-fighting ability

Immunotherapy, treatments that reinvigorate immune cells' anti-cancer activity or reprogram T cells to target cancer, has shown promise in treating leukemias but has not yet been realized in solid tumors.

30 May 2024

Older adults with a criminal background found to have higher risk of developing dementia

Using national registry data, Carmen Solares Canal identified individuals over fifty and collected data on their criminal convictions and health.

30 May 2024

New molecular analysis unravels the biological mechanisms of pediatric brain tumors

A study conducted by researchers from the D'Or Institute for Research and Education (IDOR) and the Rede D'Or Pathological Anatomy in conjunction with several North American institutions, including the National Cancer Institute (NIH), used new molecular analyses to unravel the biological mechanisms of pediatric brain tumors and refine their classification.

30 May 2024

Opioid receptors play unexpected role in gut nervous system development

Researchers at Rice University have revealed a previously unknown function of opioid receptors in the development of the enteric nervous system (ENS), often referred to as the "brain in the gut."

29 May 2024

Researchers overturn the prevailing theory for colorectal tumor initiation

Research led by Weill Cornell Medicine provides new evidence that most colorectal cancers begin with the loss of intestinal stem cells, even before cancer-causing genetic alterations appear.

29 May 2024

Study finds Plexin-B1 could be key to Alzheimer’s treatment, enhancing glial cell response

Researchers discovered that Plexin-B1 plays a crucial role in regulating peri-plaque glial nets in Alzheimer’s disease, potentially opening new avenues for treatment by targeting this protein.

29 May 2024

MUSC researchers unravel the mystery of cancer recurrence

MUSC Hollings Cancer Center researchers have unlocked a discovery that could help to explain why cancer can recur in patients who have undergone chemotherapy or radiotherapy.

28 May 2024

New paper reveals the broad potential of TNIK as a therapeutic target for some aging-related diseases

A new paper in Trends in Pharmacological Sciences from researchers at generative artificial intelligence (AI)- and robotics-powered clinical stage drug discovery company Insilico Medicine ("Insilico") and ETH Zurich reveals the broad potential of TNIK as a therapeutic target for some of the most pervasive aging-related diseases, including fibrosis, cancer, obesity, and Alzheimer's.

28 May 2024

Understanding the link between EBV-infected B cells and multiple sclerosis

The Wistar Institute's Paul M. Lieberman, Ph.D., and lab team led by senior staff scientist and first author, Samantha Soldan, Ph.D., have demonstrated how B cells infected with the Epstein-Barr virus (EBV) can contribute to a pathogenic, inflammatory phenotype that contributes to multiple sclerosis (MS); the group has also shown how these problematic B cells can be selectively targeted in a way that reduces the damaging autoimmune response of multiple sclerosis.

28 May 2024

Discovery of promising protein candidate opens new avenues for treating metabolic disorders

A University of Saskatchewan (USask) research team's discovery of the additional health benefits of an appetite-suppressing protein has doubled the potential for scientists to find new avenues for treating obesity and metabolic disorders in animals and people.

28 May 2024

Changing the landscape of R&D to build clinical success from the ground up

In this interview, NewsMedical talks to Amanda Jones at Revvity about the strategies and solutions available to revolutionize the landscape of R&D in clinical research.

From Revvity 28 May 2024

Heart failure triggers multimorbidity by altering stem cells, study reveals

Researchers identified that heart failure (HF) promotes multimorbidity by altering hematopoietic stem cells (HSCs) to produce pro-inflammatory macrophages, increasing vulnerability in multiple organs. The study highlights the role of suppressed TGF-β signaling in these alterations, contributing to chronic inflammation and subsequent health issues.

28 May 2024

Research project targets plastic particles and climate change as driving factors for antimicrobial resistance

A research project based at Heidelberg University and Heidelberg University Hospital targets plastic particles and climate change as driving factors for the spread of antimicrobial resistance (AMR) in the environment.

27 May 2024

Study finds human body lice can transmit plague bacteria

Researchers adapted a strain of human body lice to study their infection dynamics with Yersinia pestis, finding that lice can become infected and transmit the plague bacterium.

26 May 2024

Study links diverse Gardnerella species in pregnant women to higher preterm birth risk

Researchers investigated the diversity of Gardnerella species in the vaginal microbiomes of pregnant women, finding an association between higher Gardnerella richness and increased risk of preterm delivery.

26 May 2024

Study sheds new light on the intricate molecular mechanisms underlying schizophrenia

Schizophrenia is a complex disease with variable presentations, and the diverse nature of this mental health disorder has made understanding the mechanisms that cause the disease, and subsequently developing effective treatments, especially challenging.

24 May 2024

Two new studies offer insights into the molecular biology of neuropsychiatric disease

Working under the umbrella of the PsychENCODE Consortium, the mental health research project established in 2015 by the National Institutes of Health, a team of Mount Sinai scientists has uncovered important new insights into the molecular biology of neuropsychiatric disease through two new studies published in a special issue of Science on Friday, May 24.

24 May 2024

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Genes News and Research

Single infusion of engineered T-cells achieves lasting asthma remission in mice

Researchers uncover two classes of genetic causes for pediatric chordoma

Unveiling the epigenetic impact of prenatal amphetamine exposure using C. elegans models

How tight binding between immune cells dictates T cell cancer-fighting ability

Older adults with a criminal background found to have higher risk of developing dementia

New molecular analysis unravels the biological mechanisms of pediatric brain tumors

Opioid receptors play unexpected role in gut nervous system development

Researchers overturn the prevailing theory for colorectal tumor initiation

Study finds Plexin-B1 could be key to Alzheimer’s treatment, enhancing glial cell response

MUSC researchers unravel the mystery of cancer recurrence

New paper reveals the broad potential of TNIK as a therapeutic target for some aging-related diseases

Understanding the link between EBV-infected B cells and multiple sclerosis

Discovery of promising protein candidate opens new avenues for treating metabolic disorders

Changing the landscape of R&D to build clinical success from the ground up

Heart failure triggers multimorbidity by altering stem cells, study reveals

Research project targets plastic particles and climate change as driving factors for antimicrobial resistance

Study finds human body lice can transmit plague bacteria

Study links diverse Gardnerella species in pregnant women to higher preterm birth risk

Study sheds new light on the intricate molecular mechanisms underlying schizophrenia

Two new studies offer insights into the molecular biology of neuropsychiatric disease

Discover how SciY empowers scientists

Why use light scattering to analyze proteins and viral vectors?

Changing the landscape of R&D to build clinical success from the ground up

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