Preclinical News and Research

RSS

Tufts' new ingestible microbiome sampling pill completes preclinical trials

Significant progress has been made at Tufts University School of Engineering in the development of a small device, about the size of a vitamin pill, that can be swallowed and passed through the gastrointestinal tract to sample the full inventory of microorganisms in an individual's gastro-intestinal tract.

14 Jun 2024

New armored CAR T cell therapy boosts response in Relapsed non-Hodgkin lymphoma patients

While CAR T cell therapy has revolutionized treatment for many blood cancers, including non-Hodgkin lymphoma (NHL), many patients who receive CAR T cell therapy do not experience a long-term remission.

13 Jun 2024

Open-ILD: Pioneering stem cell research to combat interstitial lung disease

Imagine a world where breathing is a luxury and a cough marks the sound of an inner battle. Interstitial Lung Disease (ILD), a condition characterised by inflammation and fibrosis, is a major cause of severe respiratory illness and can occur in children.

13 Jun 2024

From Discovery Biology to ELRIG Chair: A Conversation with Melanie Leveridge

In this interview, we speak with Melanie Leveridge, Vice President of Discovery Biology at AstraZeneca and Chair of the Board for ELRIG UK, to discuss her extensive career in the pharmaceutical industry, her role in fostering scientific innovation, and her vision for ELRIG's future.

From ELRIG (UK) Ltd. 13 Jun 2024

New AARF-D award supports Temple researchers to explore synapse function in the aging brain

Late-life depression is a major risk factor for Alzheimer's disease, in particular because it accelerates progression from mild cognitive impairment to dementia.

12 Jun 2024

Human antibodies show promise against Black widow spider venom

There are various types of widow spiders, including black, red, and brown varieties in North and South America, the Australian redback spider, and several button spider species that inhabit South Africa.

12 Jun 2024

Enterprise Therapeutics publishes preclinical profile of ETD001, a novel inhaled ENaC blocker

Enterprise Therapeutics Ltd (Enterprise), a biopharmaceutical company dedicated to the discovery and development of novel therapies to improve the lives of people with respiratory diseases, today announced the publication of a peer reviewed study in the Journal of Cystic Fibrosis1.

12 Jun 2024

New brain connectivity model predicts dementia years before diagnosis

Whether the default-mode network (DMN) effective connectivity can predict future dementia diagnosis at the individual level.

10 Jun 2024

Xylitol linked to higher risk of cardiovascular events, Cleveland Clinic study finds

Cleveland Clinic researchers found higher amounts of the sugar alcohol xylitol are associated with increased risk of cardiovascular events like heart attack and stroke.

7 Jun 2024

New approach reduces the required drug dosage for cancer treatment

Traditional chemotherapy often poses significant challenges, including severe side effects, damage to healthy tissue and limited efficacy.

6 Jun 2024

Novel PET radiotracer enables same-day imaging of gastrointestinal cancer biomarker

A new PET radiotracer enables same-day imaging of the important gastrointestinal cancer biomarker known as Claudin18.2 (CLDN18.2).

6 Jun 2024

Higher amounts of sugar alcohol xylitol associated with increased risk of cardiovascular events

Cleveland Clinic researchers found higher amounts of the sugar alcohol xylitol are associated with increased risk of cardiovascular events like heart attack and stroke.

6 Jun 2024

Study links PFAS exposure to increased cardiovascular disease risk in postmenopausal women

New research from the University of Illinois Urbana-Champaign has linked multiple types of per- and polyfluoroalkyl substances (PFAS, also known as "forever chemicals") with increased risk of cardiovascular diseases in postmenopausal women.

5 Jun 2024

Synergistic cytotoxicity in pancreatic cancer: HDAC, PARP inhibitors, and decitabine show promise

A new research paper was published in Oncotarget's Volume 15 on June 3, 2024, entitled, "Synergistic cytotoxicity of histone deacetylase and poly-ADP ribose polymerase inhibitors and decitabine in pancreatic cancer cells: Implications for novel therapy."

5 Jun 2024

Artificial intelligence accelerates natural-product antibiotic discovery

Almost a century ago, the discovery of antibiotics like penicillin revolutionized medicine by harnessing the natural bacteria-killing abilities of microbes.

5 Jun 2024

Wistar scientists develop Persistent Multivalent T Cell Engager for advanced kidney cancer

Advanced clear cell renal cell carcinoma (ccRCC) is a deadly form of kidney cancer with few treatment options; even with new immunotherapies, only around one in 10 patients ultimately survive.

4 Jun 2024

Research reveals new pathways for treating never-smoker lung cancer

The primary cause of lung cancer is smoking. However, the incidence of lung cancer among never-smokers has been steadily increasing, especially among women.

4 Jun 2024

Cervix organ chips pave the way for next-generation studies on host-microbiome interactions

A group of researchers developed human Cervical Organ Chips to model the cervical interface.

4 Jun 2024

Intermittent fasting with protein pacing trumps calorie restriction in gut health and weight loss

A recent study in Nature Communications found that intermittent fasting with protein pacing (IF-P) is more effective than continuous calorie restriction (CR) in improving gut microbiota and metabolomic profiles, leading to greater weight and fat loss.

2 Jun 2024

New vessel-chip deployment platform holds promise for personalized drug testing

The pharmaceutical drug development and approval process is a multi-step undertaking that requires a plethora of testing before reaching the market.

31 May 2024

Preclinical News and Research

Tufts' new ingestible microbiome sampling pill completes preclinical trials

New armored CAR T cell therapy boosts response in Relapsed non-Hodgkin lymphoma patients

Open-ILD: Pioneering stem cell research to combat interstitial lung disease

From Discovery Biology to ELRIG Chair: A Conversation with Melanie Leveridge

New AARF-D award supports Temple researchers to explore synapse function in the aging brain

Human antibodies show promise against Black widow spider venom

Enterprise Therapeutics publishes preclinical profile of ETD001, a novel inhaled ENaC blocker

New brain connectivity model predicts dementia years before diagnosis

Xylitol linked to higher risk of cardiovascular events, Cleveland Clinic study finds

New approach reduces the required drug dosage for cancer treatment

Novel PET radiotracer enables same-day imaging of gastrointestinal cancer biomarker

Higher amounts of sugar alcohol xylitol associated with increased risk of cardiovascular events

Study links PFAS exposure to increased cardiovascular disease risk in postmenopausal women

Synergistic cytotoxicity in pancreatic cancer: HDAC, PARP inhibitors, and decitabine show promise

Artificial intelligence accelerates natural-product antibiotic discovery

Wistar scientists develop Persistent Multivalent T Cell Engager for advanced kidney cancer

Research reveals new pathways for treating never-smoker lung cancer

Cervix organ chips pave the way for next-generation studies on host-microbiome interactions

Intermittent fasting with protein pacing trumps calorie restriction in gut health and weight loss

New vessel-chip deployment platform holds promise for personalized drug testing

Revolutionizing Life Science: An Interview with SCIEX on ASMS, the SCIEX 7500+ System, and AI-Driven Quantitation

From Discovery Biology to ELRIG Chair

Breathing New Life into Diagnostics: Plasmion's SICRIT Technology

Latest Life Science News