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COVID-19 linked to rise in autoimmune lung disease, study finds

A study in eBioMedicine identifies shared immunopathology between SARS-CoV-2 infection and MDA5 autoimmunity, highlighting a surge in MDA5+ cases and interstitial lung disease during the COVID-19 pandemic.

15 May 2024

Menthol-derived molecules: promising candidates for anti-inflammatory and anti-obesity therapy

Modified derivatives of natural products have led to significant therapeutic advances and commercial success in recent times.

15 May 2024

New study reveals brain clearance of toxins is reduced during sleep and anesthesia

The adipose-neural axis plays an important role in arrhythmogenesis.

15 May 2024

Streamlining immune sensing and signaling dynamics research with INTEGRA Biosciences liquid handling tools

Immunologists in the Immune Sensing and Signaling Dynamics Group | ImmunoHUB at Instituto de Investigação e Inovação em Saúde (i3S) in Porto, Portugal, are using INTEGRA Biosciences laboratory tools to help further our understanding of the human immune system.

From INTEGRA Biosciences 15 May 2024

Oncotype DX Breast Recurrence Score test recommended by NICE for lymph node-positive breast cancer patients

Exact Sciences, a leading provider of cancer screening and diagnostic tests, today announced that the UK’s National Institute for Health and Care Excellence (NICE) has recommended the expanded use of the Oncotype DX Breast Recurrence Score® test to more effectively target chemotherapy treatment for women who have hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-), early-stage breast cancer involving up to three positive nodes and who have been through the menopause.

15 May 2024

Interactions between adipose and sympathetic neurons contribute to cardiac arrhythmia

A study in Cell Reports Medicine used an in vitro co-culture of adipocytes, cardiomyocytes, and sympathetic neurons to reveal that the adipose-neural axis plays a crucial role in arrhythmogenesis, driven by interactions between epicardial adipose tissue and the sympathetic nervous system.

14 May 2024

St. Jude researchers unveil mechanisms to block PXR and enhance drug potency

Deaths from cancer or infections can occur when available treatments are ineffective. Once turned on, pregnane X receptor (PXR) activates the expression of genes encoding enzymes that metabolize external chemicals, including drugs.

14 May 2024

Sustainable weight loss with personalized semaglutide dosing

New research being presented at the European Congress on Obesity (ECO) in Venice, Italy (12-15 May) has explored the benefits of giving personalised doses of semaglutide to patients taking part in a weight loss programme and tapering them off the medication when they reach their target weight.

14 May 2024

What is the ‘immune self,’ and how can this concept benefit immunological research?

A perspective review discusses the concept of the 'immune self' and how adaptive immune responses are influenced by self-similarity. The study emphasizes advances and challenges in defining self-similarity and its impact on immunological research.

13 May 2024

Western diet linked to chronic diseases by gut microbiota disruption

The Western diet disrupts gut microbiota and gut barrier function, increasing the risk of non-communicable chronic diseases through chronic low-grade inflammation.

13 May 2024

Obesity, metabolic syndrome impact breast cancer subtypes and mortality

In the Women's Health Initiative (WHI) randomized trial, a low-fat diet reduced breast cancer mortality, especially in women with more metabolic syndrome (MetS) components (obesity, high blood pressure, elevated blood sugar, and abnormal cholesterol).

13 May 2024

Aerobic exercise proves most effective for combating obesity-related inflammation

New research being presented at this year's European Congress on Obesity (ECO) in Venice, Italy (12-15 May), reveals the anti-inflammatory power of moderate-to-vigorous aerobic exercise in adults living with the low-grade inflammation of obesity, shedding light on its potential to help prevent multiple metabolic diseases including type 2 diabetes and atherosclerosis (clogged arteries).

13 May 2024

Researchers discover a 'training program' driving parietal cell development

Common conditions such as indigestion and heartburn as well as peptic ulcers, autoimmune gastritis and stomach and esophageal cancers have one thing in common – they involve disruptions of the normal activity of parietal cells (PCs) in the stomach, the only cells in the body that produce acid.

10 May 2024

Innovative "smart" contact lens may revolutionize glaucoma detection and monitoring

Most people with early-stage glaucoma don't know they have it, even though early treatment is key to reducing vision loss.

9 May 2024

Combination immunotherapy treatment enhances immune response for people with malignant gliomas

Investigators at the UCLA Health Jonsson Comprehensive Cancer Center have pinpointed a combination immunotherapy treatment that enhances the immune response for people with malignant gliomas, an aggressive type of brain tumor that is fast growing and difficult to treat.

9 May 2024

Enhancing the ability of natural killer cells to combat hematologic malignancies

A new study reveals a groundbreaking approach to immunotherapy, demonstrating that blocking the interaction between the CD300A receptor and phosphatidylserine (PS) significantly enhances the ability of human natural killer (NK) cells to lyse hematologic malignancies (HMs).

9 May 2024

Novel bispecific antibodies show promise against evolving SARS-CoV-2 variants

Researchers developed bispecific antibodies targeting both the N-terminal and receptor binding domains of SARS-CoV-2, demonstrating significant neutralization across various Omicron variants, suggesting potential for new COVID-19 treatments.

9 May 2024

USC study unveils iron as key driver of lung inflammation in allergic asthma

New USC research shows that iron serves as a gas pedal driving certain immune cells that cause inflammation in the lungs during an allergic asthma attack – and blocking or limiting iron may reduce the severity of symptoms.

8 May 2024

Researchers enhance CAR-T cells to target solid tumors

Researchers at the National Cancer Institute-designated Montefiore Einstein Comprehensive Cancer Center (MECCC) have shown that a breakthrough therapy for treating blood cancers can be adapted to treat solid tumors-;an advance that could transform cancer treatment.

8 May 2024

Study shows cows harbor both human and avian flu receptors in their mammary glands

Study investigates the expression of influenza A virus (IAV) receptors in bovine respiratory, cerebral, and mammary tissues, revealing significant localization of human and duck receptors in mammary glands and predominant chicken receptors in the respiratory tract, which may influence the transmission and pathogenesis of IAV in cattle.

8 May 2024

Receptor News and Research

COVID-19 linked to rise in autoimmune lung disease, study finds

Menthol-derived molecules: promising candidates for anti-inflammatory and anti-obesity therapy

New study reveals brain clearance of toxins is reduced during sleep and anesthesia

Streamlining immune sensing and signaling dynamics research with INTEGRA Biosciences liquid handling tools

Oncotype DX Breast Recurrence Score test recommended by NICE for lymph node-positive breast cancer patients

Interactions between adipose and sympathetic neurons contribute to cardiac arrhythmia

St. Jude researchers unveil mechanisms to block PXR and enhance drug potency

Sustainable weight loss with personalized semaglutide dosing

What is the ‘immune self,’ and how can this concept benefit immunological research?

Western diet linked to chronic diseases by gut microbiota disruption

Obesity, metabolic syndrome impact breast cancer subtypes and mortality

Aerobic exercise proves most effective for combating obesity-related inflammation

Researchers discover a 'training program' driving parietal cell development

Innovative "smart" contact lens may revolutionize glaucoma detection and monitoring

Combination immunotherapy treatment enhances immune response for people with malignant gliomas

Enhancing the ability of natural killer cells to combat hematologic malignancies

Novel bispecific antibodies show promise against evolving SARS-CoV-2 variants

USC study unveils iron as key driver of lung inflammation in allergic asthma

Researchers enhance CAR-T cells to target solid tumors

Study shows cows harbor both human and avian flu receptors in their mammary glands

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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