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New study identifies 17 genes driving clonal hematopoiesis in aging blood cells

Scientists have discovered 17 additional genes that drive the abnormal overgrowth of mutated blood cells as we age. The findings, published today (14 May) in Nature Genetics, provide a more complete view of the genetic factors behind clonal hematopoiesis – a process associated with ageing and linked to increased risks of blood cancers.

15 May 2024

More than 20,000 volunteers join effort to accelerate dementia drug development

More than 20,000 volunteers have been recruited to a resource aimed at speeding up the development of much-needed dementia drugs. The cohort will enable scientists in universities and industry to involve healthy individuals in clinical trials to test whether new drugs can slow the decline in various brain functions including memory and delay the onset of dementia.

15 May 2024

Metabolomics study finds biomarkers predicting autism in newborns

A study in Communications Biology utilized metabolomics in newborns to identify markers that might predict autism spectrum disorder (ASD), finding distinct metabolic profiles in children with ASD compared to typically developing children.

14 May 2024

St. Jude researchers unveil mechanisms to block PXR and enhance drug potency

Deaths from cancer or infections can occur when available treatments are ineffective. Once turned on, pregnane X receptor (PXR) activates the expression of genes encoding enzymes that metabolize external chemicals, including drugs.

14 May 2024

Children with neurodevelopmental disorders face increased risk of congenital abnormalities

Children with neurodevelopmental disorders report congenital abnormalities, such as defects of the heart and/or urinary tract, at least ten times more frequent compared to other children.

14 May 2024

New technique reveals brain cells age at different rates

Engineers at the University of California San Diego have discovered that some brain cells age more rapidly than others, and they are disproportionately abundant in individuals afflicted with Alzheimer's disease.

14 May 2024

Study proposes a novel therapeutic avenue for tackling EHF-induced cholangiocarcinogenesis

This study is led by Dr. Yiming Luo (Hepatic Surgery Centre, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology) and Professor. Huifang Liang (Hepatic Surgery Centre, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology).

14 May 2024

New study sheds light on interferon combinations' role in lupus variability

In a new study, researchers from Johns Hopkins Medicine say they have uncovered insights as to why lupus symptoms and severity present differently in individuals with the autoimmune condition, which affects up to 1.5 million Americans.

14 May 2024

Clinical trial in Seattle aims to transform treatment approaches for pediatric IBD

With pediatric inflammatory bowel disease (IBD) diagnoses on the rise globally, a clinical trial in Seattle aims to transform treatment approaches through deep molecular profiling.

14 May 2024

Unraveling the genetic connection between IBD and Parkinson's disease

Researchers at the Icahn School of Medicine at Mount Sinai have made a significant discovery, identifying genetic connections between inflammatory bowel disease (IBD) and Parkinson's disease (PD).

14 May 2024

Curcuminoid compounds show promise against COVID-19 in neuronal cells

The effects of curcumin and curcuminoids on a human neuroblastoma cell line (SH-SY5Y) infected with SARS-CoV-2.

14 May 2024

Experimental gene therapy shows promise for treating herpes infections

Researchers at Fred Hutch Cancer Center have found in pre-clinical studies that an experimental gene therapy for genital and oral herpes removed 90% or more of the infection and suppressed how much virus can be released from an infected individual, which suggests that the therapy would also reduce the spread of the virus.

13 May 2024

Genetic analysis suggests the sudden emergence of threatening viruses

Suddenly they appear and - like the SARS-CoV-2 coronavirus - can trigger major epidemics: Viruses that nobody had on their radar.

13 May 2024

Protein mechanics key to cell nucleus entry, study finds

Researchers at the Francis Crick Institute and King's College London have discovered that how soft or rigid proteins are in certain regions can dictate how fast or slow they enter the nucleus.

13 May 2024

Perspective delves into the rising threat of the MPX virus

Scientist at NIAID reviews the escalating global prevalence of the MPX virus, detailing its biology and transmission modes, and the urgent need for comprehensive research to understand and control its spread effectively.

13 May 2024

DoD grant awarded for investigating alternative polyadenylation in prostate cancer

A team led by Dr. Eddie Imada, assistant professor of research in pathology and laboratory medicine, has been awarded a three-year, $1.5 million United States Department of Defense grant for research on a cellular process called alternative polyadenylation and its role in prostate cancer.

10 May 2024

Researchers discover a 'training program' driving parietal cell development

Common conditions such as indigestion and heartburn as well as peptic ulcers, autoimmune gastritis and stomach and esophageal cancers have one thing in common – they involve disruptions of the normal activity of parietal cells (PCs) in the stomach, the only cells in the body that produce acid.

10 May 2024

Identification of pathogenicity-associated milRNAs in Fusarium oxysporum f. sp. cubense

Fusarium oxysporum f. sp. cubense (Foc) is a typical soil-borne fungus that causes Fusarium wilt by infecting the roots and blocking the vascular tissues of host banana, and threatens the global banana production.

10 May 2024

Combination immunotherapy treatment enhances immune response for people with malignant gliomas

Investigators at the UCLA Health Jonsson Comprehensive Cancer Center have pinpointed a combination immunotherapy treatment that enhances the immune response for people with malignant gliomas, an aggressive type of brain tumor that is fast growing and difficult to treat.

9 May 2024

New modular epigenome editing platform sheds light on gene regulation mechanisms

Understanding how genes are regulated at the molecular level is a central challenge in modern biology.

9 May 2024

Genes News and Research

New study identifies 17 genes driving clonal hematopoiesis in aging blood cells

More than 20,000 volunteers join effort to accelerate dementia drug development

Metabolomics study finds biomarkers predicting autism in newborns

St. Jude researchers unveil mechanisms to block PXR and enhance drug potency

Children with neurodevelopmental disorders face increased risk of congenital abnormalities

New technique reveals brain cells age at different rates

Study proposes a novel therapeutic avenue for tackling EHF-induced cholangiocarcinogenesis

New study sheds light on interferon combinations' role in lupus variability

Clinical trial in Seattle aims to transform treatment approaches for pediatric IBD

Unraveling the genetic connection between IBD and Parkinson's disease

Curcuminoid compounds show promise against COVID-19 in neuronal cells

Experimental gene therapy shows promise for treating herpes infections

Genetic analysis suggests the sudden emergence of threatening viruses

Protein mechanics key to cell nucleus entry, study finds

Perspective delves into the rising threat of the MPX virus

DoD grant awarded for investigating alternative polyadenylation in prostate cancer

Researchers discover a 'training program' driving parietal cell development

Identification of pathogenicity-associated milRNAs in Fusarium oxysporum f. sp. cubense

Combination immunotherapy treatment enhances immune response for people with malignant gliomas

New modular epigenome editing platform sheds light on gene regulation mechanisms

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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