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Early life stress can lead to substance use in male and female adolescents

Stress during childhood is associated with earlier substance use in male and female adolescents, according to a study presented Saturday at ENDO 2024, the Endocrine Society's annual meeting in Boston, Mass.

3 Jun 2024

Childhood inactivity linked to increased risk of liver disease by young adulthood

Children who are sedentary for more than six waking hours a day have a significantly increased risk of severe fatty liver disease and liver cirrhosis by young adulthood, a new study finds.

3 Jun 2024

Canagliflozin enhances senescent cell clearance, improving aging-related conditions

Whether sodium-glucose co-transporter 2 (SGLT2) inhibitors induce senolysis.

3 Jun 2024

Space experiment offers new path to fighting osteoarthritis

More than 650 million people worldwide are affected by osteoarthritis, and few treatment options exist. However, new promising results from an International Space Station (ISS) National Laboratory-sponsored experiment detail a tissue chip model that accurately reproduces the conditions under which post-traumatic osteoarthritis (PTOA) is initiated. Published in Frontiers in Space in March, these findings mark an important step forward in understanding and testing treatments for the underlying causes of osteoarthritis and related conditions.

3 Jun 2024

$Hip fracture surgery may reduce mortality for dementia patients compared to non-surgical methods$

Hip fracture surgery may reduce mortality for dementia patients compared to non-surgical methods

The decision to undergo surgery can be complicated for people living with dementia, not only due to limited decision-making capabilities, but also because participation in rehabilitation afterward is imperative to surgery success.

3 Jun 2024

Type 2 diabetes linked to higher cancer risk, especially with diabetic retinopathy, study finds

A recent study in BMC Medicine found that type 2 diabetes significantly increases the risk of various cancers, with the risk being even higher in patients with diabetic retinopathy (DR).

2 Jun 2024

Omega-3 supplements show promise in battling osteoarthritis

A recent study in Nutrients reviewed the efficacy of omega-3 polyunsaturated fatty acids (PUFAs) in slowing the progression of osteoarthritis (OA) by reducing inflammation and supporting joint health.

2 Jun 2024

Synthetic cartilage plugs may help heal osteochondral defects and avoid total knee replacements

Osteochondral defects (OCDs) can cause damage to cartilage and underlying bone, leading to chronic pain and loss of joint function.

31 May 2024

VUMC researchers discover potent antibody against influenza B

Researchers at Vanderbilt University Medical Center have isolated human monoclonal antibodies against influenza B, a significant public health threat that disproportionately affects children, the elderly and other immunocompromised individuals.

31 May 2024

From ancient remedies to modern medicine: Inorganic materials offer new hope for tissue regeneration

For centuries, civilizations have used naturally occurring, inorganic materials for their perceived healing properties.

31 May 2024

Single infusion of engineered T-cells achieves lasting asthma remission in mice

Researchers demostrate that durable asthma remission can be achieved with engineered and long-lived CAR T-cell treatment in mice.

31 May 2024

Researchers uncover two classes of genetic causes for pediatric chordoma

Little is known about the genetics and biology of chordoma, a rare and aggressive bone tumor. Chordomas occur in approximately one in a million people in the U.S. a year and only five percent of these are in children.

30 May 2024

Wake Forest researchers to study bone health post-bariatric surgery with $1.5 million NIH grant

Researchers at Wake Forest University of School of Medicine have received a five-year, $1.5 million grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases, part of the National Institutes of Health, to study bone microarchitecture in patients following bariatric surgery.

30 May 2024

Both too much and too little of a protein can lead to severe intellectual deficiencies

New research from the University of Lausanne reveals that both the excess and the deficiency of a single protein can lead to severe intellectual deficiencies.

30 May 2024

Targeting Ctdnep1: A potential therapeutic approach to combat bone loss

Osteoporosis, a condition characterized by porous and fragile bones, poses a significant threat to skeletal health.

30 May 2024

Exercise-induced exerkines: Secret weapon in disease prevention and therapy

A recent review in Signal Transduction and Targeted Therapy highlights the role of exercise-induced molecules, exerkines, in disease prevention and treatment, emphasizing their molecular mechanisms and therapeutic potential.

29 May 2024

New type of immunotherapy shows promising preclinical results against osteosarcoma

A new type of immunotherapy, developed by UCL researchers, has shown promising preclinical results against a bone cancer called osteosarcoma, as part of a study in mice.

29 May 2024

Foam-based delivery system could revolutionize gene therapies

Foam mixed with medications is already used to treat conditions such as varicose veins, hemorrhoids, wounds on the skin and even hair loss.

29 May 2024

Understanding genetic mosaicism in human cells

In a study led by Jan Korbel at the European Molecular Biology Laboratory (EMBL) and Ashley Sanders at the Berlin Institute for Medical Systems Biology of the Max Delbrück Center (MDC-BIMSB), researchers have found that approximately one in 40 human bone marrow cells carry massive chromosomal alterations – copy number variations and chromosomal rearrangements, for example – without causing any apparent disease or abnormality.

28 May 2024

Heart failure triggers multimorbidity by altering stem cells, study reveals

Researchers identified that heart failure (HF) promotes multimorbidity by altering hematopoietic stem cells (HSCs) to produce pro-inflammatory macrophages, increasing vulnerability in multiple organs. The study highlights the role of suppressed TGF-β signaling in these alterations, contributing to chronic inflammation and subsequent health issues.

28 May 2024

Bone News and Research

Early life stress can lead to substance use in male and female adolescents

Childhood inactivity linked to increased risk of liver disease by young adulthood

Canagliflozin enhances senescent cell clearance, improving aging-related conditions

Space experiment offers new path to fighting osteoarthritis

Hip fracture surgery may reduce mortality for dementia patients compared to non-surgical methods

Type 2 diabetes linked to higher cancer risk, especially with diabetic retinopathy, study finds

Omega-3 supplements show promise in battling osteoarthritis

Synthetic cartilage plugs may help heal osteochondral defects and avoid total knee replacements

VUMC researchers discover potent antibody against influenza B

From ancient remedies to modern medicine: Inorganic materials offer new hope for tissue regeneration

Single infusion of engineered T-cells achieves lasting asthma remission in mice

Researchers uncover two classes of genetic causes for pediatric chordoma

Wake Forest researchers to study bone health post-bariatric surgery with $1.5 million NIH grant

Both too much and too little of a protein can lead to severe intellectual deficiencies

Targeting Ctdnep1: A potential therapeutic approach to combat bone loss

Exercise-induced exerkines: Secret weapon in disease prevention and therapy

New type of immunotherapy shows promising preclinical results against osteosarcoma

Foam-based delivery system could revolutionize gene therapies

Understanding genetic mosaicism in human cells

Heart failure triggers multimorbidity by altering stem cells, study reveals

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