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New molecular portrait of KRAS in pancreatic cancer may guide better treatments

Researchers at UNC Lineberger Comprehensive Cancer Center and colleagues have established the most comprehensive molecular portrait of the workings of KRAS, a key cancer-causing gene or "oncogene," and how its activities impact pancreatic cancer outcomes.

6 Jun 2024

Early detection and intervention as key strategies to combat colorectal cancer

Colorectal Cancer (CRC) is set to transform from a severe disease to a controllable condition through early detection and intervention.

6 Jun 2024

New approach reduces the required drug dosage for cancer treatment

Traditional chemotherapy often poses significant challenges, including severe side effects, damage to healthy tissue and limited efficacy.

6 Jun 2024

Researchers identify a potential metabolic target for cancer immunotherapy

Researchers at the VIB-KU Leuven Center for Cancer Biology have identified a potential target for cancer immunotherapy.

6 Jun 2024

Short course of immunotherapy prior to surgery effective in treating a subset of colon cancer patients

A short course of immunotherapy was found to be highly effective in a subset of patients with colon cancer.

5 Jun 2024

SU2C-SARC032 trial: Immunotherapy reduces relapse risk in soft tissue sarcoma by 43%

For the last three decades, breakthroughs have been sparse for soft tissue sarcomas, which are rare cancers that affect muscles, fat and other connective tissues.

4 Jun 2024

Foam technology revolutionizes gene therapy, boosting efficiency and safety

Liquid foam gene delivery significantly enhances transfection efficiency and safety, offering a cost-effective alternative to conventional methods.

3 Jun 2024

Mediterranean diet linked to lower mortality risk in women

Investigators from Brigham and Women's Hospital identified and assessed underlying mechanisms that may explain the Mediterranean diet's 23 percent reduction in all-cause mortality risk for American women.

31 May 2024

Thailand grapples with colorectal cancer epidemic

According to research led by Prof. Varut Lohsiriwat, Professor of Surgery, Division of General Surgery (Section of Colorectal Surgery) of Siriraj Hospital, at Mahidol University, CRC is the third most common cancer in Thailand, accounting for 11% of the cancer burden. It is the only malignancy with an increased incidence in both genders in the country.

30 May 2024

Saudi Arabia lags in CRC screening despite high awareness of early detection benefits

According to the statistics of the Saudi National Cancer Registry issued by the Saudi Health Council for 2020, colorectal cancer (CRC) is ranked second among types of cancer, and first in men and third in women accounting for 12.3% with 1729 cases among all registered cancer cases.

30 May 2024

New weapon against cancer: "DNA warhead" targets mutant protein in tumor cells

Tumor protein P53 (TP53) plays an important role in suppressing the growth of tumors. Mutations in the gene for TP53 can have a disastrous effect, hampering the body's ability to fight tumors and even encouraging their growth.

29 May 2024

Researchers overturn the prevailing theory for colorectal tumor initiation

Research led by Weill Cornell Medicine provides new evidence that most colorectal cancers begin with the loss of intestinal stem cells, even before cancer-causing genetic alterations appear.

29 May 2024

Abdominal pain and hematochezia could be crucial red flags for early-onset colorectal cancer

The study identifies key symptoms like abdominal pain and hematochezia as significant indicators of early-onset colorectal cancer and stresses the importance of early diagnosis to improve survival rates.

28 May 2024

New paper reveals the broad potential of TNIK as a therapeutic target for some aging-related diseases

A new paper in Trends in Pharmacological Sciences from researchers at generative artificial intelligence (AI)- and robotics-powered clinical stage drug discovery company Insilico Medicine ("Insilico") and ETH Zurich reveals the broad potential of TNIK as a therapeutic target for some of the most pervasive aging-related diseases, including fibrosis, cancer, obesity, and Alzheimer's.

28 May 2024

Study reveals pivotal role of the circadian clock in enhancing checkpoint inhibitor cancer therapy

A multidisciplinary research team at the University of California, Irvine has revealed that the circadian clock – the biological pacemaker that governs daily rhythms in physiological processes, including immune functions – can be leveraged to enhance the efficacy of checkpoint inhibitor cancer therapy.

28 May 2024

Study suggests broccoli may reduce cancer risk

A meta-analysis of over 730,000 individuals indicates that high broccoli consumption is linked to lower cancer prevalence, though more robust research is needed to confirm its chemopreventive properties.

27 May 2024

Immunotherapy-chemotherapy combo boosts survival for patients with metastatic colorectal cancer

A study led by UCLA Health Jonsson Comprehensive Cancer Center researchers found that using a combination of experimental immunotherapy drugs with chemotherapy significantly improves progression-free survival and overall survival for patients with metastatic colorectal cancer who have previously undergone standard chemotherapy treatment when compared to those who received the targeted therapy regorafenib alone.

24 May 2024

Physician-pharmacy integration not associated with change in the care of cancer patients

Integration of pharmacies with physician practices, where on-site pharmacies open at physician practice locations, is a growing trend in cancer treatment.

23 May 2024

New AI model sets benchmark in digital pathology with superior cancer diagnostics

Researchers developed Prov-GigaPath, a whole-slide pathology foundation model using a novel vision transformer architecture. The model demonstrates superior performance in mutation prediction, cancer subtyping, and vision-language tasks. It leverages large-scale real-world data from over 30,000 patients to enhance clinical diagnostics.

23 May 2024

New study reveals how genes can alter the cancer-fighting power of fruits and fiber

A study in eBioMedicine uncovers two genetic loci that modify the impact of fiber and fruit intake on colorectal cancer risk, highlighting gene-diet interactions.

22 May 2024

Colorectal News and Research

New molecular portrait of KRAS in pancreatic cancer may guide better treatments

Early detection and intervention as key strategies to combat colorectal cancer

New approach reduces the required drug dosage for cancer treatment

Researchers identify a potential metabolic target for cancer immunotherapy

Short course of immunotherapy prior to surgery effective in treating a subset of colon cancer patients

SU2C-SARC032 trial: Immunotherapy reduces relapse risk in soft tissue sarcoma by 43%

Foam technology revolutionizes gene therapy, boosting efficiency and safety

Mediterranean diet linked to lower mortality risk in women

Thailand grapples with colorectal cancer epidemic

Saudi Arabia lags in CRC screening despite high awareness of early detection benefits

New weapon against cancer: "DNA warhead" targets mutant protein in tumor cells

Researchers overturn the prevailing theory for colorectal tumor initiation

Abdominal pain and hematochezia could be crucial red flags for early-onset colorectal cancer

New paper reveals the broad potential of TNIK as a therapeutic target for some aging-related diseases

Study reveals pivotal role of the circadian clock in enhancing checkpoint inhibitor cancer therapy

Study suggests broccoli may reduce cancer risk

Immunotherapy-chemotherapy combo boosts survival for patients with metastatic colorectal cancer

Physician-pharmacy integration not associated with change in the care of cancer patients

New AI model sets benchmark in digital pathology with superior cancer diagnostics

New study reveals how genes can alter the cancer-fighting power of fruits and fiber

Discover how SciY empowers scientists

Why use light scattering to analyze proteins and viral vectors?

Changing the landscape of R&D to build clinical success from the ground up

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