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Precision-guided treatment boosts outcomes in children with high-risk cancers

Study reveals that precision-guided treatment (PGT) improves outcomes in high-risk pediatric cancer patients, but clinical adoption remains low due to physician uncertainty and lack of long-term survival data.

10 Jun 2024

Key protein orco crucial for ant olfactory neuron survival and social behavior

While smell plays a considerable role in the social interactions of humans-;for instance, signaling fear or generating closeness-;for ants, it is vitally important.

7 Jun 2024

MGI Tech launches whole workflow solution for agricultural large-scale low-pass whole genome sequencing at PAG Asia 2024

MGI Tech Co., Ltd. (“MGI”), a company committed to building core tools and technologies that drive innovation in life science, today announced a highly efficient whole workflow solution for agricultural large-scale Low-pass whole genome sequencing (Low-pass WGS) based on its proprietary DNBSEQTM platforms during this year’s International Plant and Animal Genome Conference Asia (PAG Asia 2024), taking place on June 5-7 in Shenzhen, China.

From MGI 7 Jun 2024

Genetic discovery reveals key to inflammatory diseases

Researchers discovered that a specific haplotype on chromosome 21 is linked to five inflammatory diseases, offering insights into potential new treatments.

7 Jun 2024

New molecular portrait of KRAS in pancreatic cancer may guide better treatments

Researchers at UNC Lineberger Comprehensive Cancer Center and colleagues have established the most comprehensive molecular portrait of the workings of KRAS, a key cancer-causing gene or "oncogene," and how its activities impact pancreatic cancer outcomes.

6 Jun 2024

Precision medicine revolutionizes outcomes for high-risk pediatric cancer patients

In a world-first, Australian researchers and clinicians have shown that precision medicine – where treatment is tailored to an individual child's cancer – leads to significantly improved outcomes in children with high risk cancer.

6 Jun 2024

Study links PFAS exposure to increased cardiovascular disease risk in postmenopausal women

New research from the University of Illinois Urbana-Champaign has linked multiple types of per- and polyfluoroalkyl substances (PFAS, also known as "forever chemicals") with increased risk of cardiovascular diseases in postmenopausal women.

5 Jun 2024

Synergistic cytotoxicity in pancreatic cancer: HDAC, PARP inhibitors, and decitabine show promise

A new research paper was published in Oncotarget's Volume 15 on June 3, 2024, entitled, "Synergistic cytotoxicity of histone deacetylase and poly-ADP ribose polymerase inhibitors and decitabine in pancreatic cancer cells: Implications for novel therapy."

5 Jun 2024

Artificial intelligence accelerates natural-product antibiotic discovery

Almost a century ago, the discovery of antibiotics like penicillin revolutionized medicine by harnessing the natural bacteria-killing abilities of microbes.

5 Jun 2024

Novel technique maps enhancer-gene interactions in single cells

The human genome contains about 23,000 genes, but only a fraction of those genes are turned on inside a cell at any given time.

5 Jun 2024

New computational method developed for linking DNA marks to gene activity

Scientists at La Jolla Institute for Immunology (LJI) have developed a new computational method for linking molecular marks on our DNA to gene activity.

4 Jun 2024

Research reveals new pathways for treating never-smoker lung cancer

The primary cause of lung cancer is smoking. However, the incidence of lung cancer among never-smokers has been steadily increasing, especially among women.

4 Jun 2024

Precision medicine doubles progression-free survival in young cancer patients

Cancer is the leading cause of disease-related death in children in most developed countries, and at least a quarter of these patients are diagnosed with aggressive high-risk or relapsed cancers, with an expected five-year survival rate of less than 30%.

31 May 2024

Super-resolution microscopy offers high-resolution view of virus replication inside cells

A new, nano-scale look at how the SARS-CoV-2 virus replicates in cells may offer greater precision in drug development, a Stanford University team reports in Nature Communications.

31 May 2024

Non-coding gene mutation linked to monogenic neurodevelopmental disorders

Researchers at the Icahn School of Medicine at Mount Sinai and others have identified a neurodevelopmental disorder, caused by mutations in a single gene, that affects tens of thousands of people worldwide.

31 May 2024

Researchers uncover two classes of genetic causes for pediatric chordoma

Little is known about the genetics and biology of chordoma, a rare and aggressive bone tumor. Chordomas occur in approximately one in a million people in the U.S. a year and only five percent of these are in children.

30 May 2024

Decoding the function of SRSF1 protein in RNA splicing and translation regulation

RNA transcription is the genomic process in which a cell produces a duplicate of a gene's DNA sequence.

30 May 2024

Genomic evidence of prenatal origins in childhood acute myeloid leukemia

A team of researchers from the Institute of Oncology of the University of Oviedo (IUOPA), the Josep Carreras leukemia Research Institute, the University of Barcelona and the Centre for Biomedical Research in Cancer Network (CIBERONC) have demonstrated that some childhood leukemia originate during embryonic development, although they do not manifest after a few months after birth.

30 May 2024

New antibiotic lolamicin shows promise in fighting drug-resistant infections

Researchers have developed a new antibiotic that reduced or eliminated drug-resistant bacterial infections in mouse models of acute pneumonia and sepsis while sparing healthy microbes in the mouse gut.

29 May 2024

Researchers decode spatial structure of prime editor

Joint research led by Yutaro Shuto, Ryoya Nakagawa, and Osamu Nureki of the University of Tokyo determined the spatial structure of various processes of a novel gene-editing tool called "prime editor."

29 May 2024