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New Alzheimer's drug LM11A-31 shows promise in slowing disease progression in clinical trial

A recent study in Nature Medicine found that LM11A-31, targeting the p75 neurotrophin receptor, is safe and shows promise in slowing Alzheimer's disease progression. The trial indicated significant biomarker improvements and potential benefits for further clinical investigation.

28 May 2024

Changing the landscape of R&D to build clinical success from the ground up

In this interview, NewsMedical talks to Amanda Jones at Revvity about the strategies and solutions available to revolutionize the landscape of R&D in clinical research.

From Revvity 28 May 2024

Researchers identify novel way to potentially slow down or halt Alzheimer’s progression

Researchers at the Icahn School of Medicine at Mount Sinai have made a significant breakthrough in Alzheimer's disease research by identifying a novel way to potentially slow down or even halt disease progression.

27 May 2024

In-vivo imaging to quantify collagen morphology in preclinical melanoma models during immunotherapy

Collagen, a major component of the extracellular matrix, plays a crucial role in tumor development.

23 May 2024

Tailoring polymeric micelles for improved olaparib solubility and drug release

Olaparib is a selective poly (ADP-ribose) polymerase inhibitor. However, its clinical application is hindered by low solubility and undesired pharmacokinetic profiles (e.g., relatively short circulation).

23 May 2024

Study offers insights into factors influencing older adults to stop driving

What factors lead older adults to stop driving? A new study followed older adults who had no memory or thinking problems to examine this question.

23 May 2024

Insilico Medicine's leadership to address key challenges in AI drug discovery at BIO Convention

Leadership from clinical stage artificial intelligence (AI)-powered drug discovery company Insilico Medicine ("Insilico") will attend the BIO International Convention in San Diego June 3-6 and present on key issues facing AI drug discovery.

23 May 2024

Evaluating the performance of 3D power Doppler in differential diagnosis of adnexal masses

Three-dimensional power Doppler (3DPD) ultrasound has been used for assessing adnexal masses, and in this study, we aimed to perform a meta-analysis to evaluate its role in the differential diagnosis of adnexal masses.

23 May 2024

Cognitive decline predicts driving cessation in seniors

One of the thorniest decisions facing older adults is when to give up their keys and stop driving. A new study by researchers at Washington University School of Medicine in St. Louis could provide guidance in helping seniors plan ahead.

22 May 2024

Study reveals endurance exercise's impact on the biological molecules of animals and humans

As part of an ongoing national research effort to better understand how physical activity improves health and prevents disease, seven University of Colorado Department of Medicine faculty members contributed to an article recently published in Nature, an international journal of science.

22 May 2024

Improved animal model captures full picture of periodontal disease progression

Periodontal disease, represented by periodontitis, is the leading cause of tooth loss and affects close to one in five adults worldwide.

22 May 2024

ERS Genomics and IRBM sign CRISPR/Cas9 license agreement

ERS Genomics Limited (‘ERS’), the CRISPR licensing Company, and IRBM, a leader in the field of drug discovery, today announced a non-exclusive CRISPR/Cas9 license agreement. The agreement grants IRBM access to ERS’ CRISPR/Cas9 patent portfolio.

From ERS Genomics 21 May 2024

Researchers design new regenerative medicine therapy to accelerate diabetic wound repair

Researchers at the Icahn School of Medicine at Mount Sinai have designed a regenerative medicine therapy to speed up diabetic wound repair.

20 May 2024

Transportation of cancer nanomedicines into solid tumors

A new study conducted by the Wilhelm Lab at the University of Oklahoma examines a promising development in biomedical nanoengineering.

20 May 2024

Insilico and NVIDIA unveil new LLM transformer for solving biological and chemical tasks

In a new paper, researchers from clinical stage artificial intelligence (AI)-driven drug discovery company Insilico Medicine ("Insilico"), in collaboration with NVIDIA, present a new large language model (LLM) transformer for solving biological and chemical tasks called nach0.

20 May 2024

Immune checkpoint protein VISTA can directly turn off T-cells during immunotherapy, study finds

A Cleveland Clinic-led team of scientists and physicians have discovered that the immune checkpoint protein VISTA can directly turn off tumor-fighting T-cells during immunotherapy and resist treatment.

17 May 2024

POSTECH and ImmunoBiome make significant breakthrough in the fight against cancer

A team of POSTECH and ImmunoBiome has made a significant breakthrough in the fight against cancer. Their research, published in the May issue of Nature Immunology (Volume 25, pages790–801,2024), explores a dietary-derived bacterial strain, IMB001.

17 May 2024

Genes and age reveal new insights into cognitive variability, study finds

Study examines the effects of specific genes and age on cognition, revealing potential for creating genotype- and cognition-stratified cohorts for future research.

16 May 2024

New therapy shows greater weight loss in mice by targeting brain's appetite center

A groundbreaking paper in Nature describes a promising new therapy for obesity that leads to greater weight loss in mice than existing medications.

16 May 2024

Researchers find beneficial effects of a novel drug in the management of myocardial infarction

Researchers from the Cardiac Regeneration and Heart Failure Research Group (ICREC) at the Germans Trias i Pujol Research Institute (IGTP) and the Heart Institute of the Germans Trias Hospital(iCor) have found beneficial effects of the novel drug Sacubitril/Valsartan in the management of myocardial infarction (MI).

14 May 2024

Preclinical News and Research

New Alzheimer's drug LM11A-31 shows promise in slowing disease progression in clinical trial

Changing the landscape of R&D to build clinical success from the ground up

Researchers identify novel way to potentially slow down or halt Alzheimer’s progression

In-vivo imaging to quantify collagen morphology in preclinical melanoma models during immunotherapy

Tailoring polymeric micelles for improved olaparib solubility and drug release

Study offers insights into factors influencing older adults to stop driving

Insilico Medicine's leadership to address key challenges in AI drug discovery at BIO Convention

Evaluating the performance of 3D power Doppler in differential diagnosis of adnexal masses

Cognitive decline predicts driving cessation in seniors

Study reveals endurance exercise's impact on the biological molecules of animals and humans

Improved animal model captures full picture of periodontal disease progression

ERS Genomics and IRBM sign CRISPR/Cas9 license agreement

Researchers design new regenerative medicine therapy to accelerate diabetic wound repair

Transportation of cancer nanomedicines into solid tumors

Insilico and NVIDIA unveil new LLM transformer for solving biological and chemical tasks

Immune checkpoint protein VISTA can directly turn off T-cells during immunotherapy, study finds

POSTECH and ImmunoBiome make significant breakthrough in the fight against cancer

Genes and age reveal new insights into cognitive variability, study finds

New therapy shows greater weight loss in mice by targeting brain's appetite center

Researchers find beneficial effects of a novel drug in the management of myocardial infarction

Changing the landscape of R&D to build clinical success from the ground up

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

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