Molecular & Structural Biology

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Study reveals protein structure similarities in Alzheimer's and Down syndrome

More than 90% of people with Down syndrome, the most common chromosomal disorder in humans and the most frequent genetic cause of intellectual disability, are diagnosed with Alzheimer's disease by ages 55-60.

29 Mar 2024

Rapid miRNA detection with one-pot isothermal rolling circle amplification

This study is led by Professor Jue Ruan (Chinese Academy of Agricultural Sciences, Shenzhen, China). The authors developed a one-pot isothermal detection method based on rolling circle amplification (RCA) for rapid and specific detection of miRNAs and short RNA fragments.

29 Mar 2024

Research offers first insights into the mechanism behind synaptic development

The first analysis of how synaptic proteins change during early development reveals differences between mice and marmosets but also what's different in individuals with autism spectrum disorders.

28 Mar 2024

AI-powered method predicts protein dynamics to accelerate drug discovery

Understanding the structure of proteins is critical for demystifying their functions and developing drugs that target them.

27 Mar 2024

Advanced sequencing reveals eye microbiome variances linked to dry eye

Researchers have used advanced sequencing technology to determine how the mix of microbes present in patients with healthy eyes differs from the mix found in patients with dry eye.

26 Mar 2024

New glycan found to play a key role in nasal colonization of whooping cough bacteria

Researchers have identified a new complex-carbohydrate biomolecule, or glycan, that plays a key role in the nasal colonization of the Bordetella bacteria responsible for whooping cough.

25 Mar 2024

New compound extracted from African catfish skin mucas exhibits powerful antibacterial properties

Scientists report they have extracted a compound with powerful antibacterial properties from the skin of farmed African catfish.

25 Mar 2024

Boosting mRNA activity and longevity with multi-tailed structures

Messenger RNA (mRNA) made its big leap into the public limelight during the pandemic, thanks to its cornerstone role in several COVID-19 vaccines

22 Mar 2024

Mapping the aging brain's protein landscape

Researchers at LMU and the SyNergy Cluster of Excellence have analyzed how the proteome of specific brain cells changes as we age.

22 Mar 2024

Natural molecule trigonelline can help to improve muscle health and function

A research consortium led by Nestlé Research in Switzerland and the Yong Loo Lin School of Medicine, National University of Singapore (NUS Medicine) made a recent discovery that the natural molecule trigonelline present in coffee, fenugreek, and also in the human body, can help to improve muscle health and function.

22 Mar 2024

Semarion introduces SemaCyte Multiplexing Platform to enhance cell assay data quality and speed during drug discovery

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From Semarion 20 Mar 2024

Microgravity severely disrupts rhythmic gene expression in humans, study shows

Simulated effects of microgravity, created by 60 days of constant bed rest, severely disrupts rhythmic gene expression in humans, according to a new study from the University of Surrey.

19 Mar 2024

Breakthrough research uncovers neural basis of odor perception

Scents, such as coffee, flowers, or freshly-baked pumpkin pie, are created by odor molecules released by various substances and detected by our noses.

18 Mar 2024

Whole-brain imaging data provides insights into roundworm neural activity

Joint research led by Yu Toyoshima and Yuichi Iino of the University of Tokyo has demonstrated individual differences in and successfully extracted commonalities from the whole-brain activity of roundworms.

15 Mar 2024

Proteotyping unveils new extremophiles in high-altitude lakes

Perfectly adapted microorganisms live in extreme environments from deep-sea trenches to mountaintops. Learning more about how these extremophiles survive in hostile conditions could inform scientists about life on Earth and potential life on other planets.

15 Mar 2024

Clay Wright awarded prestigious MIRA funding for engineering common cellular signals

Clay Wright, assistant professor in the College of Agriculture and Life Sciences' Department of Biological Systems Engineering, was awarded a prestigious Maximizing Investigators' Research Award from the National Institute of General Medical Sciences, part of the National Institutes of Health.

14 Mar 2024

Ricoh and ERS Genomics enter into CRISPR/Cas9 license agreement

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From ERS Genomics 13 Mar 2024

Researchers discover diverse and spatially coordinated cardiac cells involved in heart development

Researchers use a combination of scRNA-seq and multiplexed error-robust fluorescence in situ hybridization to better understand cardiac cell types.

13 Mar 2024

New custom-designed proteins can efficiently reach intramembrane targets

Hitting targets embedded within the cell membrane has long been difficult for drug developers due to the membrane's challenging biochemical properties. Now, Scripps Research chemists have demonstrated new custom-designed proteins that can efficiently reach these "intramembrane" targets.

13 Mar 2024

LAG-3 protein structure may be the key to unlocking new cancer treatments

A molecular “snapshot” of a protein can be critical to understanding its function. Scientists at Stanford and NYU have published and investigated a new structure of the protein LAG-3 which could enable the development of new cancer treatments.

11 Mar 2024