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Molecular pathology of Schaaf-Yang syndrome: Insights into MAGEL2 gene mutations and truncated proteins

Mutations in the MAGEL2 gene, which cause Schaaf-Yan syndrome (SYS) —an ultra-rare disease that affects neuronal and cognitive development— generate truncated, non-functional proteins that tend to accumulate in the cell nucleus.

8 May 2024

New technique enables detailed mapping of proteins in individual cells

Researchers from Karolinska Institutet, together with Pixelgen Technologies, have developed and applied a technique that makes it possible to map proteins in individual cells in a completely new way, according to a new study in Nature Methods.

8 May 2024

New family of compounds shows promise as treatment for parasitic worms

An international team led by researchers at the University of Toronto has found a family of natural compounds with potential as new and more effective treatments for parasitic worms.

8 May 2024

Gene linked to intellectual disability can regulate learning and memory

A gene previously linked to intellectual disability has been found to regulate learning and memory in mice.

8 May 2024

Study shows cows harbor both human and avian flu receptors in their mammary glands

Study investigates the expression of influenza A virus (IAV) receptors in bovine respiratory, cerebral, and mammary tissues, revealing significant localization of human and duck receptors in mammary glands and predominant chicken receptors in the respiratory tract, which may influence the transmission and pathogenesis of IAV in cattle.

8 May 2024

New Quartet nanocage vaccine shows promise against coronavirus variants

Researchers have developed a novel vaccination approach using Quartet nanocages that display receptor-binding domains (RBDs) from different sarbecoviruses, showing enhanced immune responses and potential protection against diverse coronavirus strains including SARS-CoV-2 and its variants.

8 May 2024

Understanding cancer cell behavior: Cellular contractility modes and tumor aggressiveness

Understanding how cancerous cells spread from a primary tumor is important for any number of reasons, including determining the aggressiveness of the disease itself.

7 May 2024

Innovative methodologies for investigating intestinal mucus properties and response

As much as we might not want to think about it, mucus is everywhere in our bodies. It coats our airways and our digestive systems and serves as a first line of defense against pathogens, a habitat for our microbiomes, and a conveyor belt for our insides to keep everything moving smoothly.

7 May 2024

Study uncovers genetic link between height growth during puberty and long-term health in adulthood

A genetic link between height growth during puberty and long-term health in adulthood has been identified by a new study from the University of Surrey and the University of Pennsylvania.

7 May 2024

Bacterial fatty acid metabolite identified as key player in immune regulation

Gut microbiota or the population of microbial inhabitants in the intestine, plays a key role in digestion and maintenance of overall health.-

7 May 2024

Enzyme implicated in telomere repair offers new avenues for cancer therapy

A new study led by University of Pittsburgh and UPMC Hillman Cancer Center researchers shows that an enzyme called PARP1 is involved in repair of telomeres, the lengths of DNA that protect the tips of chromosomes, and that impairing this process can lead to telomere shortening and genomic instability that can cause cancer.

7 May 2024

Herpesvirus infection alters structure and function of mitochondria in the host cell

Researchers at the University of Jyväskylä have found that herpesvirus infection modifies the structure and normal function of the mitochondria in the host cell.

7 May 2024

Neural circuits revealed as key regulators in body's immune response, study finds

A recent study in Nature reveals how specific neural circuits within the body-brain axis regulate immune responses, highlighting potential new therapeutic approaches for immune disorders.

6 May 2024

Rutgers scientists create CRISPR-edited mice to study the neurobiology of Tourette disorder

In research that may be a step forward toward finding personalized treatments for Tourette disorder, scientists at Rutgers University–New Brunswick have bred mice that exhibit some of the same behaviors and brain abnormalities seen in humans with the disorder.

6 May 2024

UC San Diego's open source AI platform revolutionizes multi-target drug discovery

Scientists at UC San Diego have developed a machine learning algorithm to simulate the time-consuming chemistry involved in the earliest phases of drug discovery, which could significantly streamline the process and open doors for never-before-seen treatments.

6 May 2024

CRISPR gene editing shows promise for treating individuals with a form of inherited blindness

Results from a groundbreaking clinical trial of CRISPR gene editing in 14 individuals with a form of inherited blindness show that the treatment is safe and led to measurable improvements in 11 of the participants treated.

6 May 2024

Two studies aim to fight cancer with artificial cells

Fighting cancer with artificial cells that are capable of detecting and treating it. This is the dual objective of a research team of the Department of Cellular, Computational and Integrative Biology - Cibio of UniTrento, which has recently started two European projects funded by the Horizon Europe - EIC Pathfinder Open program.

6 May 2024

Life Science News

Molecular pathology of Schaaf-Yang syndrome: Insights into MAGEL2 gene mutations and truncated proteins

New technique enables detailed mapping of proteins in individual cells

New family of compounds shows promise as treatment for parasitic worms

Gene linked to intellectual disability can regulate learning and memory

Study shows cows harbor both human and avian flu receptors in their mammary glands

New Quartet nanocage vaccine shows promise against coronavirus variants

Understanding cancer cell behavior: Cellular contractility modes and tumor aggressiveness

Innovative methodologies for investigating intestinal mucus properties and response

Study uncovers genetic link between height growth during puberty and long-term health in adulthood

Bacterial fatty acid metabolite identified as key player in immune regulation

Enzyme implicated in telomere repair offers new avenues for cancer therapy

Herpesvirus infection alters structure and function of mitochondria in the host cell

Neural circuits revealed as key regulators in body's immune response, study finds

Rutgers scientists create CRISPR-edited mice to study the neurobiology of Tourette disorder

UC San Diego's open source AI platform revolutionizes multi-target drug discovery

CRISPR gene editing shows promise for treating individuals with a form of inherited blindness

Two studies aim to fight cancer with artificial cells

Genomics plc and GSK collaborate to harness polygenic risk scores in clinical trials

Raw meat-based diet for pets linked to drug-resistant bacteria, prompting concerns over public health risks

Wild Sumatran orangutan uses medicinal plant to treat facial wound

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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