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Review article provides novel insight into brain changes in alcohol-related sleep-wake disturbances

Review article provides novel insight into brain changes in alcohol-related sleep-wake disturbances

A review article published online in Behavioral Brain Research provides novel insight into changes that happen in the brain as a result of chronic alcohol exposure that can lead to disruptions in the sleep cycle. [More]
Tissue-level model of human airway musculature could pave way for patient-specific asthma treatments

Tissue-level model of human airway musculature could pave way for patient-specific asthma treatments

The majority of drugs used to treat asthma today are the same ones that were used 50 years ago. New drugs are urgently needed to treat this chronic respiratory disease, which causes nearly 25 million people in the United States alone to wheeze, cough, and find it difficult at best to take a deep breath. [More]
New study sheds light on relationship between schizophrenia and smoking stems

New study sheds light on relationship between schizophrenia and smoking stems

Schizophrenia is associated with increased rates and intensity of tobacco smoking. A growing body of research suggests that the relationship between schizophrenia and smoking stems, in part, from an effort by patients to use nicotine to self-medicate symptoms and cognitive impairment associated with the disease. [More]
Alternatives to cigarette smoking may still pose a risk to human health due to over-use

Alternatives to cigarette smoking may still pose a risk to human health due to over-use

Cigarette smoking kills approximately 440,000 Americans each year, according to the Centers for Disease Control and Protection. It's the leading cause of preventable death worldwide. In order to overcome this addiction, many people resort to nicotine replacement therapies. [More]
Blocking nerve signals could be effective treatment for stomach cancer

Blocking nerve signals could be effective treatment for stomach cancer

Research from Columbia University Medical Center shows that nerves may play a critical role in stomach cancer growth and that blocking nerve signals using surgery or Botox® (onabotulinumtoxinA) could be an effective treatment for the disease. [More]
Anti-cholinergic drugs could be responsible for decline in cognitive, physical function in elderly patients

Anti-cholinergic drugs could be responsible for decline in cognitive, physical function in elderly patients

Drugs widely prescribed to the elderly could be responsible for a decline in cognitive and physical function according to research from the University of East Anglia and the Regenstrief Institute. [More]
Protein once seen as promising anti-cancer compound helps to stabilize neural circuits

Protein once seen as promising anti-cancer compound helps to stabilize neural circuits

Researchers at UC San Francisco (UCSF) have discovered that endostatin, a protein that once aroused intense interest as a possible cancer treatment, plays a key role in the stable functioning of the nervous system. [More]
Scientists reveal secrets of cell membrane proteins

Scientists reveal secrets of cell membrane proteins

Rice University scientists have succeeded in analyzing transmembrane protein folding in the same way they study the proteins' free-floating, globular cousins. [More]
Thyroid hormone protects cholinergic neurons in hippocampus of naturally aged mice

Thyroid hormone protects cholinergic neurons in hippocampus of naturally aged mice

Can thyroid hormone protect neuronal function and increase the survival rate of naturally aged animals? Prof. Ailing Fu and her team, School of Pharmaceutical Sciences, Southwest University, China performed an animal experiment in which aged mice were administered with low dose of levothyroxine for 3 consecutive months. [More]
Two Regenstrief investigators receives Career Development K23 Awards from NIH

Two Regenstrief investigators receives Career Development K23 Awards from NIH

Two Regenstrief Institute investigators and Indiana University Center for Aging Research scientists -- Michael LaMantia, M.D., MPH, and Noll L. Campbell, PharmD -- have each received five-year Mentored Patient-Oriented Research Career Development K23 Awards from the National Institute on Aging at the National Institutes of Health. [More]
Duke researchers identify first piece of new brain-repair circuit

Duke researchers identify first piece of new brain-repair circuit

Duke researchers have found a new type of neuron in the adult brain that is capable of telling stem cells to make more new neurons. Though the experiments are in their early stages, the finding opens the tantalizing possibility that the brain may be able to repair itself from within. [More]
Uncontrollable sweating of hyperhidrosis can have serious impact on person

Uncontrollable sweating of hyperhidrosis can have serious impact on person

Sweating is a natural function of the body to cool it down during physical exertion or from a warm environment or to even help cope with emotional situations. [More]
National clinical trial to test new avenue for tinnitus treatment

National clinical trial to test new avenue for tinnitus treatment

UT Southwestern Medical Center will take part in a national clinical trial to test a device that could provide relief for people suffering from tinnitus, a persistent buzzing or ringing sound in the ears. The device uses nervous system stimuli to rewire parts of the brain, in hopes of significantly reducing or removing tinnitus. [More]
Young adult smokers may experience changes in structures of brains due to cigarette smoking

Young adult smokers may experience changes in structures of brains due to cigarette smoking

The young, it turns out, smoke more than any other age group in America. Unfortunately, the period of life ranging from late adolescence to early adulthood is also a time when the brain is still developing. [More]
TSRI study shows how aging affects brain's neural circuitry

TSRI study shows how aging affects brain's neural circuitry

How aging affects communication between neurons is not well understood, a gap that makes it more difficult to treat a range of disorders, including Alzheimer's and Parkinson's disease. [More]
EnVivo Pharmaceuticals starts encenicline Phase 3 study in patients with Alzheimer's disease

EnVivo Pharmaceuticals starts encenicline Phase 3 study in patients with Alzheimer's disease

EnVivo Pharmaceuticals, a company dedicated to developing a broad range of novel therapies for central nervous system diseases, today announced it has initiated COGNITIV AD, a Phase 3 clinical program evaluating its novel alpha-7 (α7) potentiator, encenicline-hydrochloride (EVP-6124), in patients with Alzheimer's disease. The program is being conducted under a Special Protocol Assessment agreement with the FDA. [More]
Underlying loss of awareness during partial seizures is same as deep sleep

Underlying loss of awareness during partial seizures is same as deep sleep

Epilepsy patients with complex partial seizures have impaired consciousness during seizure episodes and typically have no memory of the event. However, the mechanisms of seizure unconsciousness are unclear. [More]
mTOR protein: A key mediator of antidepressant effects of ketamine

mTOR protein: A key mediator of antidepressant effects of ketamine

Two years ago, mammalian target of rapamycin or mTOR, a signaling protein, was identified as a key mediator of the antidepressant effects of ketamine, the first rapidly acting antidepressant medication to be identified. [More]
Research could refine next generation of drugs to help treat dementia

Research could refine next generation of drugs to help treat dementia

A £1.1 million grant to understand how one of the brain's key neurotransmitters called 'acetylcholine' influences brain activity has been awarded to University of Bristol researchers. The Wellcome Trust award will help scientists understand more precisely how the release of acetylcholine is changing brain cell activity to influence memory and cognition. [More]
Georgia University scientists identify cause of muscle weakness disease myasthenia gravis

Georgia University scientists identify cause of muscle weakness disease myasthenia gravis

An antibody to a protein critical to enabling the brain to talk to muscles has been identified as a cause of myasthenia gravis, researchers report. [More]