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National clinical trial to test new avenue for tinnitus treatment

National clinical trial to test new avenue for tinnitus treatment

UT Southwestern Medical Center will take part in a national clinical trial to test a device that could provide relief for people suffering from tinnitus, a persistent buzzing or ringing sound in the ears. The device uses nervous system stimuli to rewire parts of the brain, in hopes of significantly reducing or removing tinnitus. [More]
Young adult smokers may experience changes in structures of brains due to cigarette smoking

Young adult smokers may experience changes in structures of brains due to cigarette smoking

The young, it turns out, smoke more than any other age group in America. Unfortunately, the period of life ranging from late adolescence to early adulthood is also a time when the brain is still developing. [More]
TSRI study shows how aging affects brain's neural circuitry

TSRI study shows how aging affects brain's neural circuitry

How aging affects communication between neurons is not well understood, a gap that makes it more difficult to treat a range of disorders, including Alzheimer's and Parkinson's disease. [More]
EnVivo Pharmaceuticals starts encenicline Phase 3 study in patients with Alzheimer's disease

EnVivo Pharmaceuticals starts encenicline Phase 3 study in patients with Alzheimer's disease

EnVivo Pharmaceuticals, a company dedicated to developing a broad range of novel therapies for central nervous system diseases, today announced it has initiated COGNITIV AD, a Phase 3 clinical program evaluating its novel alpha-7 (α7) potentiator, encenicline-hydrochloride (EVP-6124), in patients with Alzheimer's disease. The program is being conducted under a Special Protocol Assessment agreement with the FDA. [More]
Underlying loss of awareness during partial seizures is same as deep sleep

Underlying loss of awareness during partial seizures is same as deep sleep

Epilepsy patients with complex partial seizures have impaired consciousness during seizure episodes and typically have no memory of the event. However, the mechanisms of seizure unconsciousness are unclear. [More]
mTOR protein: A key mediator of antidepressant effects of ketamine

mTOR protein: A key mediator of antidepressant effects of ketamine

Two years ago, mammalian target of rapamycin or mTOR, a signaling protein, was identified as a key mediator of the antidepressant effects of ketamine, the first rapidly acting antidepressant medication to be identified. [More]

Research could refine next generation of drugs to help treat dementia

A £1.1 million grant to understand how one of the brain's key neurotransmitters called 'acetylcholine' influences brain activity has been awarded to University of Bristol researchers. The Wellcome Trust award will help scientists understand more precisely how the release of acetylcholine is changing brain cell activity to influence memory and cognition. [More]
Georgia University scientists identify cause of muscle weakness disease myasthenia gravis

Georgia University scientists identify cause of muscle weakness disease myasthenia gravis

An antibody to a protein critical to enabling the brain to talk to muscles has been identified as a cause of myasthenia gravis, researchers report. [More]
Researchers describe why current medications only moderately reduce Fragile X symptoms

Researchers describe why current medications only moderately reduce Fragile X symptoms

When you experience something, neurons in the brain send chemical signals called neurotransmitters across synapses to receptors on other neurons. How well that process unfolds determines how you comprehend the experience and what behaviors might follow. In people with Fragile X syndrome, a third of whom are eventually diagnosed with Autism Spectrum Disorder, that process is severely hindered, leading to intellectual impairments and abnormal behaviors. [More]
TSRI scientists identify set of compounds to treat multiple sclerosis in new way

TSRI scientists identify set of compounds to treat multiple sclerosis in new way

Scientists at The Scripps Research Institute (TSRI) have identified a set of compounds that may be used to treat multiple sclerosis (MS) in a new way. Unlike existing MS therapies that suppress the immune system, the compounds boost a population of progenitor cells that can in turn repair MS-damaged nerve fibers. [More]
Researchers take major step in development of possible treatment for stroke recovery

Researchers take major step in development of possible treatment for stroke recovery

Researchers at The University of Texas at Dallas have taken a step toward developing a new treatment to aid the recovery of limb function after strokes. [More]

New research leads to better understanding of what happens during heart failure

New research from Western University (London, Canada) is leading to a better understanding of what happens during heart failure; knowledge that could lead to better therapeutics or a more accurate predictor of risk. [More]
Smokers with a history of major depressive disorder (MDD) taking varenicline have significantly higher likelihood of quitting smoking than placebo

Smokers with a history of major depressive disorder (MDD) taking varenicline have significantly higher likelihood of quitting smoking than placebo

Results of a Pfizer-commissioned study published this month in Annals of Internal Medicine reveal that smokers with a past or present diagnosis of major depressive disorder (MDD)* taking varenicline had a significantly higher likelihood of quitting smoking (after 12 weeks and at 52 weeks) than those who were given a placebo. [More]
Neurobiologists create specific memories by direct manipulation of brain

Neurobiologists create specific memories by direct manipulation of brain

By studying how memories are made, UC Irvine neurobiologists created new, specific memories by direct manipulation of the brain, which could prove key to understanding and potentially resolving learning and memory disorders. [More]

Researchers suggest new key to switch off signaling pathways that lead to hypertension

A team of University of California, San Diego researchers has designed new compounds that mimic those naturally used by the body to regulate blood pressure. The most promising of them may literally be the key to controlling hypertension, switching off the signaling pathways that lead to the deadly condition. [More]

Researchers uncover role of IKACh in pacemaker activity and heart rate regulation

Researchers have uncovered a previously unknown role for the acetylcholine-activated inward-rectifying potassium current (IKACh) in cardiac pacemaker activity and heart rate regulation, according to a study in The Journal of General Physiology. [More]
Nerves play critical role in development and spread of prostate tumors, say researchers

Nerves play critical role in development and spread of prostate tumors, say researchers

Researchers at Albert Einstein College of Medicine of Yeshiva University have found that nerves play a critical role in both the development and spread of prostate tumors. Their findings, using both a mouse model and human prostate tissue, may lead to new ways to predict the aggressiveness of prostate cancer and to novel therapies for preventing and treating the disease. The study published online today in the July 12 edition of Science. [More]
Molecularly imprinted polymer receptors for nicotine recognition in biological systems

Molecularly imprinted polymer receptors for nicotine recognition in biological systems

Researchers from the National Environmental Engineering Research Institute in Nehru Marg, India have added another piece to the puzzle of how to synthetize an artificial nicotine receptor. [More]

Purified components of ginger help asthma patients breathe more easily

Gourmands and foodies everywhere have long recognized ginger as a great way to add a little peppery zing to both sweet and savory dishes; now, a study from researchers at Columbia University shows purified components of the spicy root also may have properties that help asthma patients breathe more easily. [More]
Takeda, Lundbeck announce presentation of data from four studies that evaluate vortioxetine for MDD

Takeda, Lundbeck announce presentation of data from four studies that evaluate vortioxetine for MDD

Takeda Pharmaceutical Company Limited and H. Lundbeck A/S today announced that the companies will be presenting new data from four studies that evaluated effectiveness in treating the overall symptoms of depression in patients taking vortioxetine, an investigational agent under review with the U.S. Food and Drug Administration for the treatment of major depressive disorder. [More]