Allodynia News and Research

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Allodynia, meaning "other pain", is a painful (noxious) response to a usually non-painful (innocuous) stimulus and can be either static or mechanical. Allodynia differs from referred pain, but can occur in areas other than the one stimulated. It is dysesthetic. Allodynia is different from hyperalgesia, an extreme reaction to a stimulus which is normally painful.

Herpes zoster vaccination and healthy aging: Study connect the dots

Vaccination with recombinant zoster vaccine (RZV) prevents Herpes Zoster (HZ) infection.

30 Nov 2023

New insights into migraine etiology: the role of hepatocyte growth factor

The causal links between pro-inflammatory cytokine expression and migraine.

10 Nov 2023

Mast cell receptor linked to alcohol withdrawal-associated headaches

Researchers investigate the role of the mast-cell-specific receptor Mas-related G-protein-coupled receptor B2 (MrgprB2) in alcohol-withdrawal-induced headaches.

2 Nov 2023

How alcohol intake contributes to increased pain and hypersensitivity

Chronic alcohol consumption may make people more sensitive to pain through two different molecular mechanisms-;one driven by alcohol intake and one by alcohol withdrawal.

21 Apr 2023

Does irritable bowel syndrome result from gravity?

New research discussed the hypothesis that irritable bowel syndrome (IBS) may result from gravity.

5 Dec 2022

Pitt neuroscientists uncover additional complexities behind sensation of pain from light touch

Researchers from the Pittsburgh Center for Pain Research at the University of Pittsburgh School of Medicine announced today in the journal Neuron that they've uncovered additional complexities behind mechanical allodynia--the sensation of pain from innocuous stimuli, such as light touch.

11 Nov 2020

A highly conserved protein contributes to sensing mechanical pain, study shows

Researchers at McGill University have discovered that a protein found in the membrane of our sensory neurons are involved in our capacity to feel mechanical pain, laying the foundation for the development of powerful new analgesic drugs.

24 Feb 2020

Scientists use toxin from rattlesnake venom for chronic pain

Rattlesnake (Crotalus adamanteus) is the largest venomous snake in North America, reaching 8 feet and weighing up to 10 pounds. In the past, medical experts believe that the toxin in rattlesnake venom, crotoxin, is a promising compound for the treatment of chronic pain.

18 Feb 2020

Light touch on the skin loses its pleasure in people with migraine

A recent study published in the journal Cephalalgia, the official journal of the International Headache Society, builds on the sensorial characteristics of migraine patients.

14 Feb 2020

Neuroimaging study reveals structural changes in the brain of migraine patients

A neuroimaging study recently published in the journal Cephalalgia, the official journal of the International Headache Society, shared more evidence of structural changes in the brain of migraine patients.

13 Jan 2020

Meta-analysis highlights predictors of chronic migraine

A meta-analysis published in the journal Cephalalgia, the official journal of the International Headache Society, highlights the predictors of chronic migraine.

7 Jan 2020

Brain protein plays a prominent role in the maintenance of chronic pain

A protein called RGS4 (Regulator of G protein signaling 4) plays a prominent role in the maintenance of long-term pain states and may serve as a promising new target for the treatment of chronic pain conditions, according to research conducted at the Icahn School of Medicine at Mount Sinai and published in print October 16, in The Journal of Neuroscience.

11 Oct 2019

Protein implicated in neuron growth and cell adhesion appears crucial for pain sensitization

Researchers from Japan's Osaka University have made an important leap in our understanding of how chronic pain conditions develop.

20 Aug 2019

Scientists discover new pain-sensing organ underneath the skin

Researchers have discovered a new sensory organ located underneath the skin. The discovery could lead to the development of new, more effective pain killers.

19 Aug 2019

Effective dose of cannabidiol for safe pain relief without the typical 'high'

In the wake of cannabis legalization, a team of scientists at the Research Institute of the McGill University Health Center and McGill University have delivered encouraging news for chronic pain sufferers by pinpointing the effective dose of marijuana plant extract cannabidiol for safe pain relief without the typical "high" or euphoria produced by the THC.

25 Oct 2018

Dectin-1 pathway could be important new target for treatment of candidiasis, study shows

Candida albicans infection (candidiasis) can cause skin, genital, or oral pain. Many studies have attempted to understand the source of pain in candidiasis; none have provided a clear explanation, until now.

29 Aug 2018

Columbia researchers identify nerve cells that drive fruit fly's escape behavior

Columbia University researchers have identified the nerve cells that initiate a fly's escape response: that complex series of movements in which an animal senses, and quickly maneuvers away from, something harmful such as high heat.

20 Mar 2018

Pioneering study may pave way for effective painkillers to treat neuropathic pain

A pioneering international study, carried out by the University of Granada, Harvard University, the University of California, Los Angeles, the University of Florida, Laval University and the Jackson Laboratory has conducted an in-depth analysis of the molecular differences between the most common symptoms associated with neuropathic pain.

21 Feb 2018

Researchers show how dopamine falls and fluctuates during migraine headache

Using PET scans of the brain, University of Michigan researchers showed that dopamine falls and fluctuates at different times during a migraine headache.

29 Mar 2017

Highly caffeinated alcoholic drinks may induce changes in the adolescent brain similar to cocaine

Drinking highly caffeinated alcoholic beverages triggers changes in the adolescent brain similar to taking cocaine, and the consequences last into adulthood as an altered ability to deal with rewarding substances, according to a Purdue University study.

25 Oct 2016