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Allodynia, meaning "other pain", is a painful (noxious) response to a usually non-painful (innocuous) stimulus and can be either static or mechanical. Allodynia differs from referred pain, but can occur in areas other than the one stimulated. It is dysesthetic. Allodynia is different from hyperalgesia, an extreme reaction to a stimulus which is normally painful.

Positive results from KAI Pharmaceuticals' pain therapeutic program

20. October 2009 08:12
KAI Pharmaceuticals, Inc., a privately held drug discovery and development company, announced positive preclinical results from its program targeting the gamma protein kinase C (PKC) pathway for the development of novel therapies for pain. [More]

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Report on osteoarthritis and its treatment

19. September 2009 01:29
Research and Markets (http://www.researchandmarkets.com/research/8b7bbd/pain_in_osteoarthr) has announced the addition of John Wiley and Sons Ltd's new report "Pain in Osteoarthritis" to their offering. [More]

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Phase 3 trial results of LEVADEX orally inhaled migraine therapy to be presented

11. September 2009 06:45
MAP Pharmaceuticals, Inc. announced today that it will present analysis of data from the efficacy portion of the first Phase 3 trial of its novel LEVADEX orally inhaled migraine therapy, currently in development, at the 14th Congress of the International Headache Society. [More]

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Endocannabinoids found to spread and prolong pain

13. August 2009 19:54
Imagine that you're working on your back porch, hammering in a nail. Suddenly you slip and hit your thumb instead - hard. The pain is incredibly intense, but it only lasts a moment. After a few seconds (and a few unprintable words) you're ready to start hammering again. [More]

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Compound from coral offers hope fpr neuropathic pain

4. August 2009 19:55
A compound initially isolated from a soft coral (Capnella imbricata) collected at Green Island off Taiwan, could lead scientists to develop a new set of treatments for neuropathic pain - chronic pain that sometimes follows damage to the nervous system. [More]

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Common migraine pain condition allodynia also prevalent in cluster headache

27. May 2009 16:23
A pain condition common in people with migraines also has a high prevalence in patients with cluster headache, according to a study conducted by researchers at the Jefferson Headache Center at Jefferson Hospital for Neuroscience. [More]

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KAI Pharmaceuticals reports positive results for KAI-1678 in pain reduction

19. November 2008 22:22
KAI Pharmaceuticals, Inc., a privately held drug discovery and development company, today announced preclinical results demonstrating the effectiveness of KAI-1678 in reversing pain (hyperalgesia and allodynia) in multiple preclinical models. [More]

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MRI reveals relationship between depression and pain

4. November 2008 02:20
The brains of individuals with major depressive disorder appear to react more strongly when anticipating pain and also display altered functioning of the neural network that modifies pain sensitivity, according to a report in the November issue of Archives of General Psychiatry , one of the JAMA/Archives journals. [More]

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Migraine exacerbates skin sensitivity or pain

21. April 2008 19:04
People with migraine are more likely to experience exacerbated skin sensitivity or pain after non-painful daily activities such as rubbing one's head, combing one's hair and wearing necklaces or earrings, compared to people with other types of headache, according to a study published in the April 22, 2008, issue of Neurology, the medical journal of the American Academy of Neurology. [More]

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Migraine sufferers found to have brain differences

20. November 2007 22:59
According to new research from the U.S., migraine sufferers have structural differences in the part of the brain that deals with pain. [More]

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People with migraines have differences in cortex area of the brain

19. November 2007 22:02
People with migraines have differences in an area of the brain that helps process sensory information, including pain, according to a study published in the November 20, 2007, issue of Neurology, the medical journal of the American Academy of Neurology. [More]

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Why the cold hurts - research has implications for pain relief

20. June 2007 08:35
Freeing knotted shoelaces with fingers that are frozen stiff is extremely difficult and can even be painful. [More]

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Hearing protein TRPA1 also involved with pain perception

21. July 2005 05:05
The same protein that “translates” sound into nerve signals to the brain and enables individuals to hear is also required for pain perception, researchers from Northwestern University Feinberg School of Medicine have found. [More]

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Stronger version of chickenpox vaccine cuts incidence and severity of shingles in older adults

1. June 2005 20:08
In one of the largest adult vaccine clinical trials ever, researchers have found that an experimental vaccine against shingles (zoster vaccine) prevented about half of cases of shingles--a painful nerve and skin infection--and dramatically reduced its severity and complications in vaccinated persons who got the disease. The findings appear in the June 2 issue of The New England Journal of Medicine. [More]

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Scientists develop a way to block the signals responsible for neuropathic pain

1. June 2005 09:56
Remember how it felt the last time you burned your finger on a hot stove? Imagine what it's like to have that burning pain in your hands or feet all the time and know there's virtually nothing you can do about it. [More]

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