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More support for amyloidosis as earliest AD biomarker

More support for amyloidosis as earliest AD biomarker

A longitudinal study of people with autosomal dominant Alzheimer’s disease shows that β-amyloid deposition begins well before neurodegeneration and cognitive decline. [More]
Prodromal Alzheimer’s phase ‘may span decades’

Prodromal Alzheimer’s phase ‘may span decades’

Marked reductions in cognitive performance are present up to 18 years before people develop Alzheimer’s disease dementia, research shows. [More]
Early neuronal lysosomal dysfunction could help predict AD

Early neuronal lysosomal dysfunction could help predict AD

Blood levels of altered lysosomal proteins may help detect preclinical Alzheimer’s disease, researchers report. [More]
Research progress with promising Alzheimer's drug Xanamem

Research progress with promising Alzheimer's drug Xanamem

Actinogen Limited (Actinogen Medical, ASX: ACW), an Australian biotechnology company focused on the development of novel treatments for Alzheimer’s disease and other major age-related neurodegenerative disorders, is pleased to announce that it has received ethics approval to initiate the third and final stage of the second Phase I trial of its lead Alzheimer’s drug candidate, Xanamem™. [More]
Iron may underlie effect of Alzheimer’s risk allele

Iron may underlie effect of Alzheimer’s risk allele

Ferritin in the cerebrospinal fluid of patients with Alzheimer’s disease is associated with the APOE ε4 risk allele and predicts cognitive outcomes, a study shows. [More]
Studies refine amyloid imaging role in dementia

Studies refine amyloid imaging role in dementia

Two meta-analyses published in JAMA help to define the role of amyloid imaging in dementia. [More]
Predominant first Alzheimer’s symptoms vary with diagnosis age

Predominant first Alzheimer’s symptoms vary with diagnosis age

The symptoms presented by patients newly diagnosed with Alzheimer’s disease vary with age, with younger patients less likely to have initial memory problems, research shows. [More]

Scripps Florida scientists uncover surprising new details of potential alzheimer’s treatment

The new study points to promising new directions using a known therapeutic strategy for Alzheimer’s disease—a disorder that will affect nearly 14 million Americans by 2050, according to the Alzheimer’s Association... [More]
Long-term effects of using cognitive-enhancing drugs by healthy people need to be determined

Long-term effects of using cognitive-enhancing drugs by healthy people need to be determined

The government, pharmaceutical industry, and national medical organisations need to work together to look at the harms and benefits of long-term use of cognitive-enhancing drugs by healthy individuals, say neuroscientists Professor Barbara Sahakian and Dr Sharon Morein-Zamir from the University of Cambridge in the UK, writing in a Personal View in The Lancet Psychiatry journal. [More]
Big data helps discover gephyrin protein's connection in human history

Big data helps discover gephyrin protein's connection in human history

Big data: It's a term we read and hear about often, but is hard to grasp. Computer scientists at Washington University in St. Louis' School of Engineering & Applied Science tackled some big data about an important protein and discovered its connection in human history as well as clues about its role in complex neurological diseases. [More]
Researchers present new studies on cognition and reasoning at CNS conference in San Francisco

Researchers present new studies on cognition and reasoning at CNS conference in San Francisco

Even rats can imagine: A new study finds that rats have the ability to link cause and effect such that they can expect, or imagine, something happening even if it isn't. [More]
Discovery opens new drug development avenues for treating multiple diseases

Discovery opens new drug development avenues for treating multiple diseases

Researchers at the University of California, San Diego School of Medicine have discovered a control switch for the unfolded protein response (UPR), a cellular stress relief mechanism drawing major scientific interest because of its role in cancer, diabetes, inflammatory disorders and several neural degenerative disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS), otherwise known as Lou Gehrig's disease. [More]
Study: Blood test may help diagnose Fragile X syndrome related disorders in women

Study: Blood test may help diagnose Fragile X syndrome related disorders in women

A blood test may shed new light on Fragile X syndrome related disorders in women, according to a new study published in the March 25, 2015, online issue of Neurology, the medical journal of the American Academy of Neurology. Fragile X is the most common inherited form of intellectual disability and the most frequent genetic cause of autism. [More]
Iceland paint a genomic picture for an entire nation

Iceland paint a genomic picture for an entire nation

Researchers in Iceland have published the largest ever studies of whole-genome data and effectively deduced the genetic code of “an entire nation.” [More]
Immunotherapy reverses memory problems in animal model of Alzheimer's disease

Immunotherapy reverses memory problems in animal model of Alzheimer's disease

A new study from the University of Texas Medical Branch at Galveston has revealed that a single dose of an immunotherapy reverses memory problems in an animal model of Alzheimer's disease. The article appears in the March 25 issue of the Journal of Neuroscience. [More]
UCLA-led team validates first standardized protocol for tracking early signs of Alzheimer's disease

UCLA-led team validates first standardized protocol for tracking early signs of Alzheimer's disease

After six years of painstaking research, a UCLA-led team has validated the first standardized protocol for measuring one of the earliest signs of Alzheimer's disease -- the atrophy of the part of the brain known as the hippocampus. [More]
Study: Progression of dysfunctional tau protein drives cognitive decline in Alzheimer's disease

Study: Progression of dysfunctional tau protein drives cognitive decline in Alzheimer's disease

By examining more than 3,600 postmortem brains, researchers at Mayo Clinic's campuses in Jacksonville, Florida, and Rochester, Minnesota, have found that the progression of dysfunctional tau protein drives the cognitive decline and memory loss seen in Alzheimer's disease. [More]
Olive ingredients may prevent Alzheimer's disease

Olive ingredients may prevent Alzheimer's disease

It has long been proven that people who follow a Mediterranean diet and keep physically and mentally active are less likely to suffer from dementia. Olives in particular appear to play a key role in this regard. But just what are the substances contained in these small, oval fruit that are so valuable? This is what a Hessen-based group of researchers from the Goethe University Frankfurt, the Technical University of Darmstadt and Darmstadt company N-Zyme BioTec GmbH intends to find out. The three-year project "NeurOliv" has a project volume of 1.3 million Euros and is funded by the Federal Ministry of Education and Research as part of the high-tech initiative "KMU-innovativ Biochance". [More]
New diet may significantly lower risk of Alzheimer's disease

New diet may significantly lower risk of Alzheimer's disease

A new diet, appropriately known by the acronym MIND, could significantly lower a person's risk of developing Alzheimer's disease, even if the diet is not meticulously followed, according to a paper published online for subscribers in March in the journal Alzheimer's & Dementia: The Journal of the Alzheimer's Association. [More]
β-amyloid cleared of blame for early memory decline

β-amyloid cleared of blame for early memory decline

A “seminal” imaging study suggests that worsening memory in adults is not necessarily an indicator of β-amyloid deposition. [More]
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