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Alzheimer's disease (AD) is an irreversible, progressive brain disease that slowly destroys memory and thinking skills and, eventually, the ability to carry out the simplest tasks of daily living. In most people with AD, symptoms first appear after age 60. AD is the most common cause of dementia among older people, but it is not a normal part of aging. Dementia refers to a decline in cognitive function that interferes with daily life and activities. AD starts in a region of the brain that affects recent memory, then gradually spreads to other parts of the brain. Although treatment can slow the progression of AD and help manage its symptoms in some people, currently there is no cure for this devastating disease.
New tool that simulates user interaction can help develop accessible ICT applications for people with disabilities

New tool that simulates user interaction can help develop accessible ICT applications for people with disabilities

A tool developed by researchers from UPM allows us to assess usability during the design and testing process of accessible ICT-based applications. [More]
Research sheds new light on biological processes underlying neurodegeneration in AD

Research sheds new light on biological processes underlying neurodegeneration in AD

Progranulin is a central protein in both neuronal survival and neurodegenerative diseases. It is thus not surprising that altered progranulin levels represent a universal theme shared across several common neurodegenerative diseases. [More]
Specific immune system genes may determine how long people can live with glioblastoma

Specific immune system genes may determine how long people can live with glioblastoma

Researchers have identified a group of immune system genes that may play a role in how long people can live after developing a common type of brain cancer called glioblastoma multiforme, a tumor of the glial cells in the brain. [More]
Mice study shows heart medication helps reduce build-up of plaque in brain's blood vessels

Mice study shows heart medication helps reduce build-up of plaque in brain's blood vessels

A new study from örebro University, published in Science Signaling today, shows that heart medication reduces the build-up of plaque in the brain's blood vessels in mice. The question is if this is true also in humans? If the answer is yes, it might bring scientists a step closer to developing a medicine against Alzheimer's disease. [More]
PET imaging with PiB may help in early diagnosis of Alzheimer's disease

PET imaging with PiB may help in early diagnosis of Alzheimer's disease

The effort to find ways to detect and diagnose preclinical Alzheimer's disease (AD) has taken a big step forward with the use of positron emission tomography (PET), a "nuclear medicine" for imaging processes in the body, when PET is used with a special 'tracer' that binds to the amyloid plaques in the brain that are a characteristic cause of AD. [More]
Technical advances in neuroimaging offer new promise to clinicians

Technical advances in neuroimaging offer new promise to clinicians

The current special issue of Technology and Innovation, Journal of the National Academy of Inventors, Volume 18, Number 1 (all open access), is devoted to the evolution of neuroimaging technology, with seven articles chronicling the latest advances in this critical area. [More]
Existing MCI screening tools result in more than 7% false-negative error rate, study finds

Existing MCI screening tools result in more than 7% false-negative error rate, study finds

Mild cognitive impairment (MCI) is a slight but noticeable and measurable decline in cognitive abilities, such as remembering names or a list of items. While changes may not be severe enough to disrupt daily life, a clinical diagnosis of MCI indicates an increased risk of eventually developing Alzheimer's disease or another type of dementia. [More]
New Spherical Brain Mapping for dementia diagnosis

New Spherical Brain Mapping for dementia diagnosis

Diagnosis, treatment and care of dementia is one of the major concerns in neurology research and associated healthcare programs. Dementia affects older age groups with a greater frequency, and as our population ages, the burden of dementia on public health is rapidly increasing. [More]
Understanding antibody transport mechanisms in the brain

Understanding antibody transport mechanisms in the brain

Diseases of the central nervous system (CNS), such as stroke, brain cancer, and Alzheimer's disease, are a serious threat affecting over 50 million Americans with an associated cost of over $750 billion per year, which is expected to grow significantly over the coming decades. [More]
Taking pregabalin drug during pregnancy could lead to major birth defects

Taking pregabalin drug during pregnancy could lead to major birth defects

A drug commonly used to treat pain, epilepsy, anxiety and other brain health disorders may be associated with an increased risk of major birth defects, according to a study published in the May 18, 2016, online issue of Neurology, the medical journal of the American Academy of Neurology. [More]
New research may increase understanding of link between olfactory decline and brain-related diseases

New research may increase understanding of link between olfactory decline and brain-related diseases

Deterioration in a person's ability to smell can sometimes be an early sign of neurodegenerative diseases such as Parkinson's or Alzheimer's. [More]
Memory test offers clue to pathological diagnosis in primary progressive aphasia

Memory test offers clue to pathological diagnosis in primary progressive aphasia

Patients with primary progressive aphasia show selective vulnerabilities in effortless learning and delayed retrieval of verbal information if their syndrome is related to Alzheimer's disease rather than frontotemporal lobar degeneration, research indicates. [More]
Physical fitness may offer protection from Alzheimer's disease, other dementias

Physical fitness may offer protection from Alzheimer's disease, other dementias

Recent research suggests that exercise might provide some measure of protection from Alzheimer's disease and other dementias. [More]
Diets rich in fruits and vegetables can help prevent chronic inflammation

Diets rich in fruits and vegetables can help prevent chronic inflammation

A new study by the University of Liverpool's Institute of Ageing and Chronic Disease has identified food stuffs that can help prevent chronic inflammation that contributes to many leading causes of death. [More]
Unlocking the dark proteome: an interview with Dr Kriwacki

Unlocking the dark proteome: an interview with Dr Kriwacki

The term dark proteome refers to proteins whose structural features and thus functions are not well understood. Many proteins within the dark proteome do not fold into stable three-dimensional structures. These proteins are called intrinsically disordered proteins (IDPs) and feature highly flexible, disordered confirmations. [More]
Cedars-Sinai researchers explore whether healthy lifestyle choices can slow or prevent Alzheimer's disease

Cedars-Sinai researchers explore whether healthy lifestyle choices can slow or prevent Alzheimer's disease

Cedars-Sinai neuroscience researchers are studying whether extensive changes in lifestyle among patients with mild cognitive impairment can slow the progression of Alzheimer's disease. [More]
New way of understanding neurodegeneration may lead to novel treatments

New way of understanding neurodegeneration may lead to novel treatments

University of Adelaide researchers have developed a new theory for the causes of dementia and other neurodegenerative diseases, involving an out-of-control immune system. [More]
Tau pathology closely tracks brain function during early AD

Tau pathology closely tracks brain function during early AD

Tau tangles may be a better indicator of cognitive changes during Alzheimer's disease progression than beta-amyloid deposition, researchers propose. [More]
Mitoxantrone drug users more likely to develop colorectal cancer

Mitoxantrone drug users more likely to develop colorectal cancer

The multiple sclerosis (MS) drug mitoxantrone may be associated with an increased risk of colorectal cancer, according to a study published in the May 11, 2016, online issue of Neurology, the medical journal of the American Academy of Neurology. Mitoxantrone suppresses the immune system. [More]
Scientists find tau protein as better marker of Alzheimer's disease

Scientists find tau protein as better marker of Alzheimer's disease

A buildup of plaque and dysfunctional proteins in the brain are hallmarks of Alzheimer's disease. While much Alzheimer's research has focused on accumulation of the protein amyloid beta, researchers have begun to pay closer attention to another protein, tau, long associated with this disease but not studied as thoroughly, in part, because scientists only recently have developed effective ways to image tau. [More]
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