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Alzheimer's disease (AD) is an irreversible, progressive brain disease that slowly destroys memory and thinking skills and, eventually, the ability to carry out the simplest tasks of daily living. In most people with AD, symptoms first appear after age 60. AD is the most common cause of dementia among older people, but it is not a normal part of aging. Dementia refers to a decline in cognitive function that interferes with daily life and activities. AD starts in a region of the brain that affects recent memory, then gradually spreads to other parts of the brain. Although treatment can slow the progression of AD and help manage its symptoms in some people, currently there is no cure for this devastating disease.
Eisai, Halozyme partner to evaluate eribulin and PEGPH20 in HER2-negative metastatic breast cancer

Eisai, Halozyme partner to evaluate eribulin and PEGPH20 in HER2-negative metastatic breast cancer

Eisai Inc. announced today that its parent company Eisai Co., Ltd. (Headquarters: Tokyo, President and CEO: Haruo Naito) and Halozyme Therapeutics, Inc. (Headquarters: San Diego, California, President and CEO: Dr. Helen Torley) have signed a clinical collaboration agreement to evaluate Eisai's agent eribulin mesylate (brand name: Halaven, "eribulin") in combination with Halozyme's investigational drug PEGPH20 (PEGylated recombinant human hyaluronidase) in first line HER2-negative metastatic breast cancer. [More]
Female patients with depression have abnormally high expression levels of glutamate receptor genes

Female patients with depression have abnormally high expression levels of glutamate receptor genes

Numerous genes that regulate the activity of a neurotransmitter in the brain have been found to be abundant in brain tissue of depressed females. This could be an underlying cause of the higher incidence of suicide among women, according to research at the University of Illinois at Chicago. [More]
Study reveals new way to help medical students learn about Alzheimer's disease

Study reveals new way to help medical students learn about Alzheimer's disease

With the growing number of people with Alzheimer's disease, understanding their care is vital for doctors. Yet medical students often just learn the facts and may only see people with advanced disease who are at the hospital or nursing home. A study shows a new way to help medical students learn about the disease—at the art museum. [More]
Natural protein fragment produced in the brain can inhibit enzyme implicated in Alzheimer's disease

Natural protein fragment produced in the brain can inhibit enzyme implicated in Alzheimer's disease

For the first time, UCLA researchers have shown that a natural protein fragment produced in the brain can act as an inhibitor of a key enzyme implicated in the onset of Alzheimer's disease, a finding that could lead to the development of new drugs to treat the disease. [More]
New study estimates link between coffee consumption habits and incidence of mild cognitive impairment

New study estimates link between coffee consumption habits and incidence of mild cognitive impairment

A new study by researchers at the University of Bari Aldo Moro, Bari, Italy, Geriatric Unit & Laboratory of Gerontology and Geriatrics, IRCCS "Casa Sollievo della Sofferenza", San Giovanni Rotondo, Foggia, Italy, and Istituto Superiore di Sanità, Roma, Italy, estimates the association between change or constant habits in coffee consumption and the incidence of mild cognitive impairment (MCI), evaluating 1,445 individuals recruited from 5,632 subjects, aged 65-84 year old, from the Italian Longitudinal Study on Aging (ILSA), a population-based sample from eight Italian municipalities with a 3.5-year median follow-up. [More]
Lidocaine benefits breast cancer survivors who experience pain during intercourse

Lidocaine benefits breast cancer survivors who experience pain during intercourse

Scientists at Oregon Health & Science University report that breast cancer survivors who experience pain during sexual intercourse, a common side effect of breast cancer treatment, may achieve comfort when liquid lidocaine is applied strategically to prevent pain. [More]
New Iowa State study finds strong link between insulin resistance and increased Alzheimer's disease risk

New Iowa State study finds strong link between insulin resistance and increased Alzheimer's disease risk

The fact that obesity increases the risk of cardiovascular disease and some cancers is well known. But a new Iowa State University study adds to the growing evidence that memory loss should also be a top concern. [More]
Inflammation plays role in onset of delirium in older adults

Inflammation plays role in onset of delirium in older adults

Delirium is an acute state of confusion that often affects older adults following surgery or serious illness. Now a study led by researchers at Beth Israel Deaconess Medical Center confirms that inflammation - an immune response that develops when the body attempts to protect itself from harmful stimuli -- plays a role in the onset of delirium. [More]
New research shows concussion may affect men and women differently

New research shows concussion may affect men and women differently

New research suggests concussion may not significantly impair symptoms or cognitive skills for one gender over another, however, women may still experience greater symptoms and poorer cognitive performance at preseason testing. [More]
Migraines may increase risk of stroke among smokers

Migraines may increase risk of stroke among smokers

New research suggests older people who experience migraines may have an increased risk of stroke, but only if they are smokers. The study is published in the July 22, 2015, online issue of Neurology, the medical journal of the American Academy of Neurology. [More]
Gladstone Institutes announces new business endeavor with Evotec and Dolby Family Ventures

Gladstone Institutes announces new business endeavor with Evotec and Dolby Family Ventures

The Gladstone Institutes announces the creation of Cure Network Ventures Inc. and Cure Network Dolby Acceleration Partners, LLC, a business endeavor with Dolby Family Ventures and Evotec AG, which will focus on Alzheimer's disease. Working through Cure Network Ventures, Inc., the new company will help expedite the translation of relevant scientific discoveries from the Gladstone Institute of Neurological Disease into the development of potential therapies. [More]
Researchers identify barriers and possible catalysts to delirium detection in emergency department

Researchers identify barriers and possible catalysts to delirium detection in emergency department

An estimated one to two million older adults with delirium visit hospital emergency departments in the United States annually. Yet about two-thirds of the cases of this sudden and potentially lethal change in mental status are unrecognized by emergency department clinicians who are under time pressure and almost always managing multiple patients at once. [More]
Mild cognitive impairment occurs more often in people diagnosed with lower ankle brachial index

Mild cognitive impairment occurs more often in people diagnosed with lower ankle brachial index

In a large population-based study of randomly selected participants in Germany, researchers found that mild cognitive impairment (MCI) occurred significantly more often in individuals diagnosed with a lower ankle brachial index (ABI), which is a marker of generalized atherosclerosis and thus cumulative exposure to cardiovascular risk factors during lifetime. [More]
Study looks at impact of amyloid imaging on diagnosis, management of patients with cognitive impairment

Study looks at impact of amyloid imaging on diagnosis, management of patients with cognitive impairment

Eli Lilly and Company and Avid Radiopharmaceuticals, Inc., a wholly owned subsidiary of Lilly, today announced new data showing that knowledge of amyloid status as determined by Florbetapir F 18 Injection imaging altered diagnosis and management in the majority of patients being studied. [More]
Researchers discover experimental drug that treats hot flashes, other menopausal symptoms without side effects

Researchers discover experimental drug that treats hot flashes, other menopausal symptoms without side effects

Researchers have discovered an experimental medication that treats hot flashes and other menopausal symptoms without the life-threatening risks of hormone replacement therapy, according to a team led by a UNT Health Science Center scientist. [More]
Study identifies new culprit in Alzheimer's disease development

Study identifies new culprit in Alzheimer's disease development

A recent study conducted at Nathan S. Kline Institute for Psychiatric Research and NYU Langone Medical Center implicates a new culprit in Alzheimer's disease development. The research reveals that ßCTF -- the precursor of the amyloid beta (Aß) peptide -- acts at the earliest stage of Alzheimer's to initiate a range of abnormalities leading to the loss of groups of neurons critical for memory formation. [More]
Alzheimer's Association recognizes Li Gan with Inge Grundke-Iqbal Award for Alzheimer's Research

Alzheimer's Association recognizes Li Gan with Inge Grundke-Iqbal Award for Alzheimer's Research

The Alzheimer's Association is recognizing Li Gan, Ph.D., for publishing influential research on the biology of Alzheimer's disease with the Inge Grundke-Iqbal Award for Alzheimer's Research. The Award was presented today during a plenary session at the Alzheimer's Association International Conference 2015 in Washington, D.C. [More]
Duke study finds that gut worms can protect babies' brains from chronic inflammation

Duke study finds that gut worms can protect babies' brains from chronic inflammation

A Duke University study in rats finds that gut worms can protect babies' brains from long-term learning and memory problems caused by newborn infections. [More]
Key differences identified among patients with ALS

Key differences identified among patients with ALS

Researchers on Mayo Clinic's Florida campus have identified key differences between patients with sporadic amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease) and those with the most common genetic form of ALS, a mutation in the C9orf72 gene. [More]
Stanford researchers identify iron-containing microglia in the brains of people with Alzheimer's disease

Stanford researchers identify iron-containing microglia in the brains of people with Alzheimer's disease

Examining post-mortem tissue from the brains of people with Alzheimer's disease, Stanford University School of Medicine investigators identified what appear to be iron-containing microglia -- specialized scavenger cells that sometimes become inflammatory -- in a particular part of the hippocampus, a key brain structure whose integrity is critical to memory formation. [More]
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