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Alzheimer's disease (AD) is an irreversible, progressive brain disease that slowly destroys memory and thinking skills and, eventually, the ability to carry out the simplest tasks of daily living. In most people with AD, symptoms first appear after age 60. AD is the most common cause of dementia among older people, but it is not a normal part of aging. Dementia refers to a decline in cognitive function that interferes with daily life and activities. AD starts in a region of the brain that affects recent memory, then gradually spreads to other parts of the brain. Although treatment can slow the progression of AD and help manage its symptoms in some people, currently there is no cure for this devastating disease.
Signs and symptoms of Lewy body dementia

Signs and symptoms of Lewy body dementia

"I watched my husband experience a decline in cognition followed by a period of what seemed like improved function only to plunge again into confusion with more frequent hallucinations," says one caregiver newly acquainted with Lewy body dementia (LBD). [More]
Study finds microglia increase neuronal firing and enhance brain cell survival after injury

Study finds microglia increase neuronal firing and enhance brain cell survival after injury

A type of immune cell widely believed to exacerbate chronic adult brain diseases, such as Alzheimer's disease and multiple sclerosis (MS), can actually protect the brain from traumatic brain injury (TBI) and may slow the progression of neurodegenerative diseases, according to Cleveland Clinic research published today in the online journal Nature Communications. [More]
New discovery links two important hypotheses in Alzheimer's disease research

New discovery links two important hypotheses in Alzheimer's disease research

In Alzheimer's disease, accumulation of amyloid plaque in the brain is believed to play an important role in many characteristic disease symptoms, including memory loss and other mental state changes. [More]
Elevated ASM activity linked to Alzheimer's disease

Elevated ASM activity linked to Alzheimer's disease

Unclogging the body's protein disposal system may improve memory in patients with Alzheimer's disease (AD), according to a study from scientists at Kyungpook National University in Korea published in The Journal of Experimental Medicine. [More]
Brain network measures placebo effects in Parkinson's disease patients

Brain network measures placebo effects in Parkinson's disease patients

Investigators at The Feinstein Institute for Medical Research have utilized a new image-based strategy to identify and measure placebo effects in randomized clinical trials for brain disorders. The findings are published in the August issue of The Journal of Clinical Investigation. [More]
Moxibustion and electroacupuncture alleviate neuronal cytoplasmic edema in AD

Moxibustion and electroacupuncture alleviate neuronal cytoplasmic edema in AD

Aberrant Wnt signaling is possibly related to the pathological changes in Alzheimer's disease (AD). Axin and β-catenin protein is closely related to Wnt signaling. [More]

Structural change in periventricular white matter may show correlation with cognitive, sensory motor deficits by aging

Ventricular enlargement has been suggested as a structural biomarker for normal aging and progression of some illnesses, such as Alzheimer's disease. [More]
People with mild traumatic brain injury may have brain damage and memory problems

People with mild traumatic brain injury may have brain damage and memory problems

Even mild traumatic brain injury may cause brain damage and thinking and memory problems, according to a study published in the July 16, 2014, online issue of Neurology, the medical journal of the American Academy of Neurology. [More]
Scientists build artificial cells programmed to eat their undesirable neighbors

Scientists build artificial cells programmed to eat their undesirable neighbors

A team of researchers has devised a Pac-Man-style power pellet that gets normally mild-mannered cells to gobble up their undesirable neighbors. The development may point the way to therapies that enlist patients’ own cells to better fend off infection and even cancer, the researchers say. A description of the work will be published July 15 in the journal Science Signaling. [More]
Research sheds light on key mechanism prevalent in Alzheimer's disease patients

Research sheds light on key mechanism prevalent in Alzheimer's disease patients

Alzheimer's disease affects approximately 5.2 million people in the United States alone, and it is the nation's sixth leading cause of death. [More]
Lilly, Immunocore enter into co-discovery and co-development collaboration to develop cancer therapies

Lilly, Immunocore enter into co-discovery and co-development collaboration to develop cancer therapies

Eli Lilly and Company and Immunocore Limited today announced they have entered into a co-discovery and co-development collaboration to research and potentially develop novel T cell-based cancer therapies. [More]
Study reveals way to alleviate memory deficits for Alzheimer's disease patients

Study reveals way to alleviate memory deficits for Alzheimer's disease patients

A new study from the Gladstone Institutes has revealed a way to alleviate the learning and memory deficits caused by apoE4, the most important genetic risk factor for Alzheimer's disease, improving cognition to normal levels in aged mice. [More]
Study: Fish oil supplements reduce cognitive decline, brain atrophy in older adults

Study: Fish oil supplements reduce cognitive decline, brain atrophy in older adults

Rhode Island Hospital researchers have completed a study that found regular use of fish oil supplements (FOS) was associated with a significant reduction in cognitive decline and brain atrophy in older adults. [More]
New avenues for treatment of Alzheimer's disease

New avenues for treatment of Alzheimer's disease

Judes Poirier, PhD, C.Q., from the Douglas Mental Health Institute and McGill University in Montr-al (Canada) and his team have discovered that a relatively frequent genetic variant actually conveys significant protection against the common form of Alzheimer's disease and can delay the onset of the disease by as much as 4 years. [More]

Neuroprotective effects of ginsenoside Rb1 on hippocampal neuronal injury, neurite outgrowth

The main pathological changes of Alzheimer's disease (AD) include amyloid-beta protein-induced hippocampal neuronal injury and neurite outgrowth impairment. [More]
B vitamins do not prevent Alzheimer's disease

B vitamins do not prevent Alzheimer's disease

Taking B vitamins doesn't slow mental decline as we age, nor is it likely to prevent Alzheimer's disease, conclude Oxford University researchers who have assembled all the best clinical trial data involving 22,000 people to offer a final answer on this debate. [More]
BAI and Novartis determine whether investigational drugs can prevent symptoms of Alzheimer's

BAI and Novartis determine whether investigational drugs can prevent symptoms of Alzheimer's

Researchers from the Banner Alzheimer's Institute (BAI) today announced a partnership with Novartis in a pioneering medical trial to determine whether two investigational anti-amyloid drugs-an active immunotherapy and an oral medication-can prevent or delay the emergence of symptoms of Alzheimer's in people at particularly high risk for developing the disease at older ages. [More]
New data on possible protective behaviors and dementia risk factors emerges at AAIC- 2014

New data on possible protective behaviors and dementia risk factors emerges at AAIC- 2014

Participation in activities that promote mental activity, and moderate physical activity in middle age, may help protect against the development of Alzheimer's disease and dementia in later life, according to new research reported today at the Alzheimer's Association International Conference- 2014 (AAIC- 2014) in Copenhagen. [More]
ADSC transplantation promotes adult neurogenesis in brains of Alzheimer's disease mice

ADSC transplantation promotes adult neurogenesis in brains of Alzheimer's disease mice

Recent evidence has demonstrated that transplantation of mesenchymal stem cells can stimulate neurogenesis in the brain of adult rat or mouse models of Alzheimer's disease (AD) and improve tissue and function injury under the condition of cerebral ischemia. [More]
Noninvasive optical imaging device helps to detect changes linked with Alzheimer's disease

Noninvasive optical imaging device helps to detect changes linked with Alzheimer's disease

A noninvasive optical imaging device developed at Cedars-Sinai can provide early detection of changes that later occur in the brain and are a classic sign of Alzheimer's disease, according to preliminary results from investigators conducting a clinical trial in Australia. [More]