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Alzheimer's disease (AD) is an irreversible, progressive brain disease that slowly destroys memory and thinking skills and, eventually, the ability to carry out the simplest tasks of daily living. In most people with AD, symptoms first appear after age 60. AD is the most common cause of dementia among older people, but it is not a normal part of aging. Dementia refers to a decline in cognitive function that interferes with daily life and activities. AD starts in a region of the brain that affects recent memory, then gradually spreads to other parts of the brain. Although treatment can slow the progression of AD and help manage its symptoms in some people, currently there is no cure for this devastating disease.
Duke to lead early-stage clinical trials for promising new neurological therapies

Duke to lead early-stage clinical trials for promising new neurological therapies

Duke University could receive up to $19 million to lead early-stage clinical trials for new drugs to treat neurological conditions such as Alzheimer's disease and neuropathy. [More]
New neuroprotective compounds may prevent development of epilepsy

New neuroprotective compounds may prevent development of epilepsy

A team led by Nicolas Bazan, MD, PhD, Boyd Professor and Director of LSU Health New Orleans' Neuroscience Center of Excellence, has developed neuroprotective compounds that may prevent the development of epilepsy. [More]
New protein may help scientists understand role of Abeta in Alzheimer's disease

New protein may help scientists understand role of Abeta in Alzheimer's disease

A new protein which will help scientists to understand why nerve cells die in people with Alzheimer's disease has been designed in a University of Sussex laboratory. [More]
Cinnamon treatment turns poor-learning mice into good ones, research shows

Cinnamon treatment turns poor-learning mice into good ones, research shows

If Dr. Kalipada Pahan's research pans out, the standard advice for failing students might one day be: Study harder and eat your cinnamon! [More]
Long-term antibiotic treatment slows progression of Alzheimer's disease through changes in gut bacteria

Long-term antibiotic treatment slows progression of Alzheimer's disease through changes in gut bacteria

Long-term treatment with broad spectrum antibiotics decreased levels of amyloid plaques, a hallmark of Alzheimer's disease, and activated inflammatory microglial cells in the brains of mice in a new study by neuroscientists from the University of Chicago. [More]
TSRI study reveals new approach to intervene in deadly disease

TSRI study reveals new approach to intervene in deadly disease

In a new study, scientists at The Scripps Research Institute have identified drug candidates that can boost a cell's ability to catch the "typos" in protein production that can cause a deadly disease called amyloidosis. [More]
NYU Langone launches Alzheimer's and Related Dementias Family Support Program for caregivers

NYU Langone launches Alzheimer's and Related Dementias Family Support Program for caregivers

Two new grants from the New York State Department of Health will enable New Yorkers with Alzheimer's diseaseand dementia, and their families, to get the most comprehensive care and support services available in the New York City area. [More]
Discriminating remembrance may be marker for early stages of memory loss in older adults

Discriminating remembrance may be marker for early stages of memory loss in older adults

People who selectively recalled positive information over neutral and negative information performed worse on memory tests conducted by University of California, Irvine neurobiologists, who said the results suggest that this discriminating remembrance may be a marker for early stages of memory loss in the elderly. [More]
New study of fMRI aims to develop efficient real-time method to detect brain activation in AD patients

New study of fMRI aims to develop efficient real-time method to detect brain activation in AD patients

Researchers at University Hospitals Case Medical Center are beginning a study of functional magnetic resonance imaging (fMRI) to detect how brain activation in patients in early and middle stages of Alzheimer's disease compares to people without it. [More]
New virus-based method opens wide range of options to treat various diseases

New virus-based method opens wide range of options to treat various diseases

The ability to switch disease-causing genes on and off remains a dream for many physicians, research scientists and patients. [More]
Researchers discover novel neuroprotection strategies to slow progression of Parkinson's disease

Researchers discover novel neuroprotection strategies to slow progression of Parkinson's disease

Using a robust model for Parkinson's disease, University of Alabama at Birmingham researchers and colleagues have discovered an interaction in neurons that contributes to Parkinson's disease, and they have shown that drugs now under development may block the process. [More]
Study provides more insight into effects of DBS in treatment of Alzheimer's disease

Study provides more insight into effects of DBS in treatment of Alzheimer's disease

New findings published today by a team of researchers led by Dr. Andres Lozano at the Krembil Neuroscience Centre of Toronto Western Hospital have provided further insight into the effects of Deep Brain Stimulation (DBS) in the treatment of Alzheimer's disease. [More]
New research shows how toxic Alzheimer's protein spreads through the brain

New research shows how toxic Alzheimer's protein spreads through the brain

A toxic Alzheimer's protein can spread through the brain--jumping from one neuron to another--via the extracellular space that surrounds the brain's neurons, suggests new research from Columbia University Medical Center. [More]
Postmenopausal estrogen supplement may not affect memory of healthy women

Postmenopausal estrogen supplement may not affect memory of healthy women

Contrary to popular belief, taking estrogen after menopause may not affect the memory and thinking abilities of healthy women no matter when the treatment is started. [More]
JAD announces recipient of 2016 Alzheimer Award

JAD announces recipient of 2016 Alzheimer Award

The Journal of Alzheimer's Disease is pleased to announce that Mark W. Bondi, PhD, ABPP/CN, Professor of Psychiatry at UC San Diego and Director of the Neuropsychological Assessment Unit at the VA San Diego Healthcare System, has been chosen as the recipient of the 2016 Alzheimer Award presented by the journal in recognition of his outstanding work on the development of a novel and promising method of staging preclinical Alzheimer's disease (AD) based on number of abnormal biomarkers that is predictive of progression to mild cognitive impairment (MCI) and AD. [More]
Genes linked to Alzheimer's disease may show effects on the brain from childhood

Genes linked to Alzheimer's disease may show effects on the brain from childhood

A gene associated with Alzheimer's disease and recovery after brain injury may show its effects on the brain and thinking skills as early as childhood, according to a study published in the July 13, 2016, online issue of Neurology, the medical journal of the American Academy of Neurology. [More]
Researchers discover new biological pathway involved in Alzheimer's disease

Researchers discover new biological pathway involved in Alzheimer's disease

Researchers have identified a new biological pathway involved in Alzheimer's disease. In experiments using fruit flies, blocking the pathway reduced the death of brain cells, suggesting that interfering with the pathway could represent a promising new strategy to treat the disease in human patients. [More]
Review highlights lack of consistent assessment tool to assess driving ability in people with Alzheimer's

Review highlights lack of consistent assessment tool to assess driving ability in people with Alzheimer's

No single assessment tool is able to consistently determine driving ability in people with Alzheimer's disease and mild cognitive impairment, a St. Michael's Hospital research review has found. [More]
17beta-Estradiol patch may help reduce Alzheimer's disease risk in newly postmenopausal women

17beta-Estradiol patch may help reduce Alzheimer's disease risk in newly postmenopausal women

Can estrogen preserve brain function and decrease the risk of Alzheimer's disease when given early in menopause? Newly postmenopausal women who received estrogen via a skin patch had reduced beta-amyloid deposits, the sticky plaques found in the brains of people with Alzheimer's disease, a Mayo Clinic study published this month in the Journal of Alzheimer's Disease found. [More]
Selfish mutant mtDNA exploits cellular defenses to cause many diseases

Selfish mutant mtDNA exploits cellular defenses to cause many diseases

Mitochondrial disorders are a chameleon-like set of diseases that take many different forms and vary widely from individual to individual. [More]
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