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Alzheimer's disease (AD) is an irreversible, progressive brain disease that slowly destroys memory and thinking skills and, eventually, the ability to carry out the simplest tasks of daily living. In most people with AD, symptoms first appear after age 60. AD is the most common cause of dementia among older people, but it is not a normal part of aging. Dementia refers to a decline in cognitive function that interferes with daily life and activities. AD starts in a region of the brain that affects recent memory, then gradually spreads to other parts of the brain. Although treatment can slow the progression of AD and help manage its symptoms in some people, currently there is no cure for this devastating disease.
Existing MCI screening tools result in more than 7% false-negative error rate, study finds

Existing MCI screening tools result in more than 7% false-negative error rate, study finds

Mild cognitive impairment (MCI) is a slight but noticeable and measurable decline in cognitive abilities, such as remembering names or a list of items. While changes may not be severe enough to disrupt daily life, a clinical diagnosis of MCI indicates an increased risk of eventually developing Alzheimer's disease or another type of dementia. [More]
New Spherical Brain Mapping for dementia diagnosis

New Spherical Brain Mapping for dementia diagnosis

Diagnosis, treatment and care of dementia is one of the major concerns in neurology research and associated healthcare programs. Dementia affects older age groups with a greater frequency, and as our population ages, the burden of dementia on public health is rapidly increasing. [More]
Understanding antibody transport mechanisms in the brain

Understanding antibody transport mechanisms in the brain

Diseases of the central nervous system (CNS), such as stroke, brain cancer, and Alzheimer's disease, are a serious threat affecting over 50 million Americans with an associated cost of over $750 billion per year, which is expected to grow significantly over the coming decades. [More]
Taking pregabalin drug during pregnancy could lead to major birth defects

Taking pregabalin drug during pregnancy could lead to major birth defects

A drug commonly used to treat pain, epilepsy, anxiety and other brain health disorders may be associated with an increased risk of major birth defects, according to a study published in the May 18, 2016, online issue of Neurology, the medical journal of the American Academy of Neurology. [More]
New research may increase understanding of link between olfactory decline and brain-related diseases

New research may increase understanding of link between olfactory decline and brain-related diseases

Deterioration in a person's ability to smell can sometimes be an early sign of neurodegenerative diseases such as Parkinson's or Alzheimer's. [More]
Memory test offers clue to pathological diagnosis in primary progressive aphasia

Memory test offers clue to pathological diagnosis in primary progressive aphasia

Patients with primary progressive aphasia show selective vulnerabilities in effortless learning and delayed retrieval of verbal information if their syndrome is related to Alzheimer's disease rather than frontotemporal lobar degeneration, research indicates. [More]
Physical fitness may offer protection from Alzheimer's disease, other dementias

Physical fitness may offer protection from Alzheimer's disease, other dementias

Recent research suggests that exercise might provide some measure of protection from Alzheimer's disease and other dementias. [More]
Diets rich in fruits and vegetables can help prevent chronic inflammation

Diets rich in fruits and vegetables can help prevent chronic inflammation

A new study by the University of Liverpool's Institute of Ageing and Chronic Disease has identified food stuffs that can help prevent chronic inflammation that contributes to many leading causes of death. [More]
Unlocking the dark proteome: an interview with Dr Kriwacki

Unlocking the dark proteome: an interview with Dr Kriwacki

The term dark proteome refers to proteins whose structural features and thus functions are not well understood. Many proteins within the dark proteome do not fold into stable three-dimensional structures. These proteins are called intrinsically disordered proteins (IDPs) and feature highly flexible, disordered confirmations. [More]
Cedars-Sinai researchers explore whether healthy lifestyle choices can slow or prevent Alzheimer's disease

Cedars-Sinai researchers explore whether healthy lifestyle choices can slow or prevent Alzheimer's disease

Cedars-Sinai neuroscience researchers are studying whether extensive changes in lifestyle among patients with mild cognitive impairment can slow the progression of Alzheimer's disease. [More]
New way of understanding neurodegeneration may lead to novel treatments

New way of understanding neurodegeneration may lead to novel treatments

University of Adelaide researchers have developed a new theory for the causes of dementia and other neurodegenerative diseases, involving an out-of-control immune system. [More]
Tau pathology closely tracks brain function during early AD

Tau pathology closely tracks brain function during early AD

Tau tangles may be a better indicator of cognitive changes during Alzheimer's disease progression than beta-amyloid deposition, researchers propose. [More]
Mitoxantrone drug users more likely to develop colorectal cancer

Mitoxantrone drug users more likely to develop colorectal cancer

The multiple sclerosis (MS) drug mitoxantrone may be associated with an increased risk of colorectal cancer, according to a study published in the May 11, 2016, online issue of Neurology, the medical journal of the American Academy of Neurology. Mitoxantrone suppresses the immune system. [More]
Scientists find tau protein as better marker of Alzheimer's disease

Scientists find tau protein as better marker of Alzheimer's disease

A buildup of plaque and dysfunctional proteins in the brain are hallmarks of Alzheimer's disease. While much Alzheimer's research has focused on accumulation of the protein amyloid beta, researchers have begun to pay closer attention to another protein, tau, long associated with this disease but not studied as thoroughly, in part, because scientists only recently have developed effective ways to image tau. [More]
Dementia risk high after ICH

Dementia risk high after ICH

A large study shows that nearly a third of patients who survive an intracerebral haemorrhage will go on to develop dementia within 4 years. [More]
Eating seafood once a week may protect against age-related memory loss

Eating seafood once a week may protect against age-related memory loss

Eating a meal of seafood or other foods containing omega-3 fatty acids at least once a week may protect against age-related memory loss and thinking problems in older people, according to a team of researchers at Rush University Medical Center and Wageningen University in the Netherlands. [More]
Genetic variations that increase PKC alpha activity may influence development of Alzheimer's disease

Genetic variations that increase PKC alpha activity may influence development of Alzheimer's disease

In Alzheimer's disease, plaques of amyloid beta protein accumulate in the brain, damaging connections between neurons. [More]
Depression course predicts dementia risk

Depression course predicts dementia risk

Patients with late-life depression have an increased risk of dementia if their symptoms increase over time, whereas a single episode of depression, even if severe, does not carry a significant risk, study findings indicate. [More]
New research on epigenetics of lactose intolerance unravels understanding of schizophrenia

New research on epigenetics of lactose intolerance unravels understanding of schizophrenia

A new study on the epigenetics of lactose intolerance may provide an approach to understanding schizophrenia and other complex, serious illnesses [More]
CoSTREAM project aims to find common mechanisms, pathways in stroke and Alzheimer's disease

CoSTREAM project aims to find common mechanisms, pathways in stroke and Alzheimer's disease

Stroke and Alzheimer's disease are major diseases imposing a huge burden on aging societies. It has long been recognized that stroke and Alzheimer's disease often co-occur, and it has been speculated that the two disorders have an overlapping pathogenesis. [More]
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