Apolipoprotein News and Research

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Unlocking Alzheimer's secrets: Study pinpoints APOE4's harmful effect on lipids

UNC School of Medicine researcher Sarah Cohen, PhD, and Ian Windham, a former PhD student from the Cohen lab, have made a new discovery about apolipoprotein E (APOE) – the biggest genetic risk factor for late-onset Alzheimer's disease.

9 Feb 2024

APOE4 genetic risk factors for Alzheimer's disease associated with increased risk of subclinical atherosclerosis

Scientists at the Centro Nacional de Investigaciones Cardiovasculares in Madrid have found that one of the most potent genetic risk factors for Alzheimer disease, apolipoprotein E4 (APOE4), is also associated with an increased risk of developing subclinical atherosclerosis in middle age.

23 Jan 2024

Alzheimer's disease found to have five distinct subtypes

Researchers identified five distinct molecular subtypes of Alzheimer's disease using proteomic sequencing, suggesting personalized treatment approaches based on each subtype's unique genetic and pathological characteristics.

10 Jan 2024

Causal effects of lipids, lipoproteins, and other metabolites on blood pressure

The causal effects of lipoprotein particles, lipids, and other metabolites on blood pressure (BP).

9 Jan 2024

Gut microbiota: the new frontier in Alzheimer’s disease research and therapy

The current evidence of the role of gut microbiota in Alzheimer’s disease (AD) pathogenesis.

8 Jan 2024

Irregular sleep patterns linked to cognitive decline in older adults, study shows

Study finds that short sleep duration and high variability in sleep patterns are significantly associated with cognitive impairment in older adults, highlighting the importance of consistent sleep for cognitive health.

5 Dec 2023

New genetic links to coronary artery calcification uncovered, offering treatment insights

A study in Nature Cardiovascular Research identifies two new genetic loci associated with coronary artery calcification (CAC), a key indicator of atherosclerosis and coronary artery disease.

5 Dec 2023

New insights into how SARS-CoV-2 evades our immune system

This review in Cellular and Molecular Immunology delves into the innate immune response to SARS-CoV-2, exploring how the virus evades immunity and the potential role of innate immunity in long-COVID and vaccine responses, shedding light on future therapeutic strategies.

23 Nov 2023

Exploring the intersection: Cardiovascular mortality trends among Alzheimer’s patients in the U.S.

Researchers compare the trends in cardiovascular disease-related mortality among patients with Alzheimer’s disease with general United States population.

23 Nov 2023

Rare APOE3-R136S mutation offers protection against Alzheimer's disease pathologies in new study

The R136S genetic mutation protected against apolipoprotein E4 (APOE4)-induced late-onset Alzheimer’s disease (LOAD).

16 Nov 2023

Investigating the link between gut inflammation, aging, and Alzheimer's disease

A recent study in discusses how gut inflammation is associated with age and Alzheimer's disease.

15 Nov 2023

"Christchurch mutation" can block detrimental effects of Alzheimer’s risk factor

Researchers at Gladstone Institutes have discovered that a rare genetic variant known as the "Christchurch mutation" can block detrimental effects of apolipoprotein E4, the best-established risk factor for the most common form of Alzheimer's disease.

13 Nov 2023

Recaticimab injection every 1-3 months may safely lower bad cholesterol

A new PCSK9 inhibitor (recaticimab) injected every one to three months may work safely and provide more flexible dosing to lower cholesterol, according to late-breaking science presented today at the American Heart Association's Scientific Sessions 2023.

13 Nov 2023

Single injection of new medication effectively eliminates Lp(a) for nearly one year

In the first human trial of a new therapeutic, a single injection of lepodisiran reduced levels of lipoprotein(a), or Lp(a), to undetectable levels for nearly one year, according to late-breaking science presented today at the American Heart Association's Scientific Sessions 2023.

13 Nov 2023

Is there an association between atrial fibrillation onset age and incident dementia?

Whether younger age at atrial fibrillation (AF) diagnosis is associated with a higher risk of incident dementia.

13 Nov 2023

Australian study shows combined genomic screening for major hereditary diseases is cost-effective and health-saving

In an Australian study published in EClinicalMedicine, researchers evaluated the impact of a combined genomic screening program for hereditary breast and ovarian cancer, Lynch syndrome, and familial hypercholesterolemia in young adults. The program proved to be cost-effective, reducing healthcare costs and averting numerous health events, while emphasizing the need for further optimization and equitable access within public healthcare systems.

12 Nov 2023

Cannabis use alters DNA methylation, with implications beyond smoking effects

A large-scale meta-analysis in Molecular Psychiatry reveals that lifetime cannabis use is associated with DNA methylation changes in peripheral blood, which could have implications for understanding the long-term health effects of cannabis consumption.

8 Nov 2023

Pharmacogenomics holds promise for personalized dementia therapies

Pharmacogenomics-based studies in the research for personalized therapeutics for dementia

8 Nov 2023

Gut health linked to Alzheimer's disease progression, experts urge dietary shift

The interactions between the gut microbiome, lipids, and Alzheimer’s disease (AD).

7 Nov 2023

Does the percentage of slow-wave sleep decline with aging, and are intra-individual declines associated with dementia risk?

Researchers investigated whether slow-wave sleep (SWS) proportions reduced as individuals aged and whether intra-individual decreases were linked to dementia risk.

1 Nov 2023

Apolipoprotein News and Research

Unlocking Alzheimer's secrets: Study pinpoints APOE4's harmful effect on lipids

APOE4 genetic risk factors for Alzheimer's disease associated with increased risk of subclinical atherosclerosis

Alzheimer's disease found to have five distinct subtypes

Causal effects of lipids, lipoproteins, and other metabolites on blood pressure

Gut microbiota: the new frontier in Alzheimer’s disease research and therapy

Irregular sleep patterns linked to cognitive decline in older adults, study shows

New genetic links to coronary artery calcification uncovered, offering treatment insights

New insights into how SARS-CoV-2 evades our immune system

Exploring the intersection: Cardiovascular mortality trends among Alzheimer’s patients in the U.S.

Rare APOE3-R136S mutation offers protection against Alzheimer's disease pathologies in new study

Investigating the link between gut inflammation, aging, and Alzheimer's disease

"Christchurch mutation" can block detrimental effects of Alzheimer’s risk factor

Recaticimab injection every 1-3 months may safely lower bad cholesterol

Single injection of new medication effectively eliminates Lp(a) for nearly one year

Is there an association between atrial fibrillation onset age and incident dementia?

Australian study shows combined genomic screening for major hereditary diseases is cost-effective and health-saving

Cannabis use alters DNA methylation, with implications beyond smoking effects

Pharmacogenomics holds promise for personalized dementia therapies

Gut health linked to Alzheimer's disease progression, experts urge dietary shift

Does the percentage of slow-wave sleep decline with aging, and are intra-individual declines associated with dementia risk?

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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