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Arteries stiffen as a consequence of age and atherosclerosis. The two leading causes of death in the developed world, myocardial infarction and stroke, are both a direct consequence of atherosclerosis. Increased arterial stiffness is associated with an increased risk of cardiovascular events.
Metabolic risk factors in overweight children linked with mild artery wall stiffness

Metabolic risk factors in overweight children linked with mild artery wall stiffness

Metabolic disorders, such as excess abdominal fat, raised blood pressure, higher levels of insulin, glucose and triglycerides and lower levels of the beneficial HDL cholesterol can be found in children as young as 6 to 8 years of age, according to a study carried out at the University of Eastern Finland. [More]
Omeros' GPCR platform unlocks new drug targets against multiple sclerosis

Omeros' GPCR platform unlocks new drug targets against multiple sclerosis

Omeros Corporation today announced positive data in the most commonly used model for studying the clinical and pathological features of multiple sclerosis (MS), further advancing its development program of GPR17-targeting compounds for the treatment of MS. Compounds previously discovered by Omeros that inhibit GPR17, an orphan G protein-coupled receptor (GPCR) unlocked by Omeros, significantly improved function from experimental autoimmune encephalomyelitis (EAE) in mice. [More]
Nutrisystem reduces arterial stiffness associated with menopause and obesity

Nutrisystem reduces arterial stiffness associated with menopause and obesity

Arturo Figueroa, a researcher in the Florida State University College of Human Sciences, has confirmed with a team of researchers that Nutrisystem, with or without low intense resistance exercise, improves arterial function in obese, postmenopausal women. [More]
Arterial elasticity link to lung function

Arterial elasticity link to lung function

People with reduced arterial elasticity may have impaired lung function, and vice versa, say US researchers. [More]
ETA receptor antagonism reduces novel cardiovascular risk factors in patients with CKD

ETA receptor antagonism reduces novel cardiovascular risk factors in patients with CKD

Blocking the receptor for proteins that constrict blood vessels reduces markers of heart-related problems in patients with chronic kidney disease (CKD), according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN). [More]

Patients with obstructive sleep apnea have same early cardiovascular damage as diabetics

Patients with obstructive sleep apnea have the same early cardiovascular damage as diabetics, according to research presented at EUROECHO and other Imaging Modalities 2012. [More]

Young vascular systems adapt to obesity

Researchers have identified physiologic changes in the vascular systems of children that appear to be an adaptive response to obesity. [More]
Study illuminates how Aldo and galectin-3 protein contribute to vascular remodeling, CHF

Study illuminates how Aldo and galectin-3 protein contribute to vascular remodeling, CHF

Cardiovascular disease will kill nearly 2.5 million people in the United States this year, according to the Centers for Disease Control. Over time, inflammation, collagen deposition and scar tissue formation can cause blood vessels to stiffen, a process called vascular fibrosis. Though researchers have known that the hormone aldosterone (Aldo) plays a role in this process, the precise mechanisms have been poorly understood. [More]
Workout in the catheter lab gives clues to ‘warm-up angina’

Workout in the catheter lab gives clues to ‘warm-up angina’

Improved coupling of vascular and ventricular circulation during exercise appears to underlie the phenomenon known as warm-up angina, a UK study shows. [More]
Anti-TNF-α therapy reduces CVD risk in patients with rheumatoid arthritis

Anti-TNF-α therapy reduces CVD risk in patients with rheumatoid arthritis

Patients with rheumatoid arthritis exhibit a sub-clinical vasculitis that may underlie their increased risk for cardiovascular disease, shows research. [More]
Apolipoprotein E plays a major role in maintaining arterial softness

Apolipoprotein E plays a major role in maintaining arterial softness

Arterial stiffening has long been considered a major risk factor for cardiovascular disease. Keeping arteries soft and supple might reduce disease risk, but the mechanisms of how arteries stave off hardening has remained elusive. [More]

Soccer scores hat-trick for hypertensive men

Soccer training can significantly reduce blood pressure and improve aerobic fitness in hypertensive middle-aged men, researchers say. [More]
Lonafarnib proves effective for children with progeria

Lonafarnib proves effective for children with progeria

Results of the first-ever clinical drug trial for children with Progeria, a rare, fatal "rapid-aging" disease, demonstrate the efficacy of a farnesyltransferase inhibitor (FTI), a drug originally developed to treat cancer. The clinical trial results, completed only six years after scientists identified the cause of Progeria, included significant improvements in weight gain, bone structure and, most importantly, the cardiovascular system, according to The Progeria Research Foundation (PRF) and Boston Children's Hospital. [More]

Renal denervation regenerates blood vessels and could reduce cardiovascular events

Renal denervation improves blood pressure and arterial stiffness in patients with therapy resistant hypertension, according to research presented at ESC Congress 2012 by Mr Klaas Franzen from the University Hospital of Schleswig-Holstein. [More]
DTU develops new computer model for AAA rupture risk evaluation

DTU develops new computer model for AAA rupture risk evaluation

A new computer model is expected to assist the medical doctors in saving patients with this potential life threatening condition. Assistant Professor Marie Sand Enevoldsen at the Technical University of Denmark (DTU) has developed a prototype computer model for AAA rupture risk evaluation. [More]
Symposium at EuroPRevent 2012 highlights benefits of oily fish consumption

Symposium at EuroPRevent 2012 highlights benefits of oily fish consumption

Most people, whether healthy or having cardiovascular disease (CVD), would benefit from regular consumption of oily fish, concluded speakers at the EuroPRevent 2012 meeting. While eating whole fish undoubtedly offers the optimum approach for increasing omega-3 intakes in both primary and secondary prevention, delegates heard, supplements have a major role to play in increasing omega-3 intakes for people who do not like fish. [More]
Omega-3 fatty acids inhibit detrimental effects of smoking on arterial function

Omega-3 fatty acids inhibit detrimental effects of smoking on arterial function

Omega-3 fatty acids may help to reduce the physical harm caused by smoking, according to a new study presented today at the World Congress of Cardiology. [More]
Tai Chi improves cardiovascular function and body strength in older adults

Tai Chi improves cardiovascular function and body strength in older adults

Exercise which can achieve both cardiovascular function and muscle strength "would be a preferred mode of training for older persons", say investigators. [More]

High fat diets cause damage to blood vessels earlier than previously thought

High fat diets cause damage to blood vessels earlier than previously thought, and these structural and mechanical changes may be the first step in the development of high blood pressure. [More]
Starvation during childhood may increase risk of heart complications

Starvation during childhood may increase risk of heart complications

Russians born during the Leningrad Siege in World War II, which was responsible for some of the greatest losses of civilian life in history, are giving scientists new strategies to identify people who experienced intrauterine growth restriction (IUGR) and starvation during childhood at greatest risk of developing long term heart complications. [More]