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New AI tool 'TORCH' successfully identifies cancer origins in unknown primary cases

A deep-learning approach for tumor origin differentiation using cytological histology.

19 Apr 2024

Cirrhosis patients face mixed infection outcomes amid pandemic healthcare shifts

The COVID-19 pandemic's influence on healthcare systems led to mixed outcomes for patients with cirrhosis, showing stable infection rates but a rise in multi-drug resistant organism (MDRO) infections.

7 Feb 2024

Study uses cellulose sheets to map body's extracellular vesicles, unlocking disease insights

Study demonstrates the use of cellulose nanofiber sheets for spatial analysis of extracellular vesicles, revealing their geographical heterogeneity in the human body, which could advance the understanding and treatment of diseases.

14 Nov 2023

Study confirms the anti-cancer effects of Kencur extract

You may know it as an aromatic spice to add flavor to your dishes or as a soothing herbal remedy to use for upset stomachs, but researchers from Osaka Metropolitan University have uncovered promising findings that Kencur, a tropical plant in the ginger family native to Southeast Asia, possesses anti-cancer effects.

28 Aug 2023

Are teicoplanin-non-susceptible Staphylococcus epidermidis strains increasing?

Researchers elucidated the incidence patterns of teicoplanin-non-susceptible Staphylococcus epidermidis (Teico-NS S. epidermidis) over six years.

8 Aug 2023

New method improves prediction of liver disease progression

A research team from the Department of Medicine III at MedUni Vienna and University Hospital Vienna has conducted a large-scale study showing the important value of repeated liver assessments by a novel method that can significantly improve risk assessment in patients with chronic liver disease.

17 Jul 2023

Small vesicles released by intestinal bacteria induce immune activation and progression of liver cirrhosis

Researchers from Niigata University and Kyoto Prefectural University have revealed that small vesicles, around 100 nm in size, released by intestinal bacteria induce immune activation and progression of liver cirrhosis, as well as reduction of serum albumin level, subsequently leading to edema and ascites.

19 Apr 2023

Liver cancer treatment can place significant financial burden on patients, analysis shows

Hepatocellular carcinoma (HCC), the most common type of liver cancer, can place a significant financial burden on patients, according to an analysis led by a researcher at UT Southwestern Medical Center.

30 Jan 2023

CAR T-cell therapy in colorectal cancer

Researchers assessed the efficacy of CAR T-cells in the immunotherapy of colorectal cancer.

21 Nov 2022

First-of-its-kind messenger RNA therapy developed for ovarian cancer, cachexia

Researchers at Oregon State University and Oregon Health & Science University have developed a promising, first-of-its-kind messenger RNA therapy for ovarian cancer as well as cachexia, a muscle-wasting condition associated with cancer and other chronic illnesses.

13 Sep 2022

Adding acetazolamide to intravenous loop diuretics decreases congestion in patients with acute decompensated heart failure

Acetazolamide added to intravenous loop diuretics decreases congestion within three days in patients with acute decompensated heart failure, according to late breaking research presented in a Hot Line session today at ESC Congress 2022.

28 Aug 2022

Clinicopathological correlations and obstetric management of pregnant women with monkeypox virus infection

Researchers described the impact, potential mechanisms, and management of maternal and fetal monkeypox virus infections.

23 Aug 2022

Study highlights the need for liver cirrhosis patients to be educated on hepatic venous pressure gradient

Just like the hypertension that people develop when their blood pressure increases, the increase of blood pressure in the main vein that supplies blood to the liver, called the portal vein, is also a dangerous situation.

31 May 2022

Researchers find potential new strategy to treat metastatic form of intra-abdominal cancer

Researchers from the National Cancer Centre Singapore (NCCS) have found a potential new strategy to treat peritoneal carcinomatosis, a metastatic form of intra-abdominal cancer, where patients are presented with limited treatment options and poor overall survival.

15 Feb 2022

Liver cirrhosis has higher hospitalization and in-hospital mortality rates in Germany

In Germany, liver cirrhosis has the highest mortality rate of any chronic disease requiring hospital admission. When diagnosed as a comorbidity of other chronic diseases, liver cirrhosis at least doubles the mortality rate.

12 Feb 2022

Study examines effect of sorafenib in patients with advanced hepatocellular carcinoma

Oncotarget published "Insulin-like growth factor 1/Child-Turcotte-Pugh composite score as a predictor of treatment outcomes in patients with advanced hepatocellular carcinoma treated with sorafenib" which reported that this study investigated the association of the IGF/CTP score with overall survival and progression-free survival of HCC patients treated with sorafenib.

28 Jun 2021

Cellular senescence of cancer-associated fibroblasts play a key role in peritoneal dissemination

Through an analysis of cellular components (cell fractions) from malignant ascites (fluid buildup in the abdomen caused by gastric cancer), a research collaboration based in Kumamoto University (Japan) has demonstrated that cellular senescence of cancer-associated fibroblasts (CAFs) play an important role in the peritoneal dissemination of gastric cancer foci (cells different from surrounding cells).

23 Mar 2021

Researchers use cachexia model to assess cancer-derived myocardial impairments

Oncotarget recently published "Evaluation of cancer-derived myocardial impairments using a mouse model" which reported that Myocardial damage in cancer patients is emphasized as a cause of death; however, there are not many murine cachexia models to evaluate cancer-derived heart disorder.

11 Feb 2021

Study identifies triggers for acute decompensation of liver cirrhosis

Chronic liver disease and even cirrhosis can go unnoticed for a long time because many patients have no symptoms: the liver suffers silently.

2 Feb 2021

Researchers develop a gene signature for predicting survival in patients with peritoneal carcinomatosis

Researchers from The University of Texas MD Anderson Cancer Center who profiled more than 45,000 individual cells from patients with peritoneal carcinomatosis (PC), a specific form of metastatic gastric cancer, defined the extensive cellular heterogeneity and identified two distinct subtypes correlated with patient survival.

4 Jan 2021