Autophagy News and Research

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Autophagy is a normal process in which a cell destroys proteins and other substances in its cytoplasm (the fluid inside the cell membrane but outside the nucleus), which may lead to cell death. Autophagy may prevent normal cells from developing into cancer cells, but it may also protect cancer cells by destroying anticancer drugs or substances taken up by them.

Research findings could help inform more effective therapies for AML

Acute myeloid leukemia (AML) is a type of cancer in which the bone marrow makes a large number of abnormal blood cells. It is the most common type of acute leukemia in adults.

24 Apr 2023

UC-led research team receives NIH grant to study the role of an enzyme in lysosome function

Once thought of as having one simple job within cells, researchers continue to learn more about the importance of organelles called lysosomes.

11 Apr 2023

Beclin-1 plays a key role in endometrial reprogramming for successful establishment of pregnancy

Throughout a woman's reproductive life, the endometrium, the mucous membrane lining the uterus, goes through cyclical remodeling. It thickens during the menstrual cycle in preparation for embryo implantation, and it is shed during menstruation when there is no fertilization.

10 Apr 2023

Promoting cellular recycling in the brain may reverse or prevent damage from traumatic brain injury

Each year about 1.5 million people in the U.S. survive a traumatic brain injury due to a fall, car accident, or a sports injury, which can cause immediate and long-term disability.

4 Apr 2023

FDA-approved drug keeps light-sensitive photoreceptors alive in lab models of LCA 10

A National Institutes of Health team has identified a compound already approved by the U.S. Food and Drug Administration that keeps light-sensitive photoreceptors alive in three models of Leber congenital amaurosis type 10 (LCA 10), an inherited retinal ciliopathy disease that often results in severe visual impairment or blindness in early childhood.

29 Mar 2023

Capsaicin and its health benefits

Researchers examine the health benefits associated with capsaicin, with a particular focus on how this compound impacts cognition and cardiovascular health.

28 Mar 2023

Metformin may reduce the risk of osteoarthritis

In a recent study published in JAMA Network Open, researchers in the United States (US) determined the risk of osteoarthritis (OA) and joint replacement among adults with type 2 diabetes (T2D) following metformin or sulfonylurea treatment.

27 Mar 2023

Study provides evidence for a strong role of autophagy in controlling intracellular infections

Researchers at the Francis Crick Institute have found that the body's process of removing old and damaged cell parts, is also an essential part of tackling infections that take hold within our cells, like TB.

23 Mar 2023

Review explores trehalose's effects on metabolism and gut microflora

researchers review the bioactive properties of trehalose and its potential pharmaceutical, medical, cosmetic, and food-related applications.

20 Mar 2023

How does dietary intervention affect aging?

Aging is a process that includes multiple interwoven mechanisms that interact with lifestyle factors. A new review seeks to encapsulate the available information on the effect of diet on aging at the cellular level in humans.

14 Mar 2023

Study shows SARS-CoV-2 causes DNA damage and elicits an altered DNA damage response

Researchers assessed the association between SARS-CoV-2 infection and DNA damage and cellular senescence.

14 Mar 2023

UVA scientists identify a detox approach to delay aging

University of Virginia scientists have identified a promising approach to delay aging by detoxifying the body of glycerol and glyceraldehyde, harmful by-products of fat that naturally accumulate over time.

9 Mar 2023

Long-term intermittent fasting can offer protection from heart-related COVID-19 complications

Intermittent fasting, especially when done over the course of decades, can have positive effects on metabolic and cardiovascular health.

7 Mar 2023

Role of phosphatidylinositol 3 kinase pathway in corneal damage due to blue light exposure

Researchers observe corneal damage by blue light exposure is due to PI3K/AKT pathway inhibition.

1 Mar 2023

Exploring the neuroprotective potential of cell-penetrating peptides, extracellular vesicles, and micro ribonucleic acids

In a recent review published in Biomedicines, researchers explored extracellular vesicles (EVs), cell-penetrating peptides (CPPs), and micro ribonucleic acids (miRNAs) as therapies for neurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD).

1 Mar 2023

Autophagy News and Research

Further Reading

Research findings could help inform more effective therapies for AML

UC-led research team receives NIH grant to study the role of an enzyme in lysosome function

Beclin-1 plays a key role in endometrial reprogramming for successful establishment of pregnancy

Promoting cellular recycling in the brain may reverse or prevent damage from traumatic brain injury

FDA-approved drug keeps light-sensitive photoreceptors alive in lab models of LCA 10

Capsaicin and its health benefits

Metformin may reduce the risk of osteoarthritis

Study provides evidence for a strong role of autophagy in controlling intracellular infections

Review explores trehalose's effects on metabolism and gut microflora

How does dietary intervention affect aging?

Study shows SARS-CoV-2 causes DNA damage and elicits an altered DNA damage response

UVA scientists identify a detox approach to delay aging

Long-term intermittent fasting can offer protection from heart-related COVID-19 complications

Role of phosphatidylinositol 3 kinase pathway in corneal damage due to blue light exposure

Exploring the neuroprotective potential of cell-penetrating peptides, extracellular vesicles, and micro ribonucleic acids

New discovery could shift the focus of Parkinson’s disease treatment

NQO2 gene as a novel potential target in Parkinson’s disease

Researchers explore Mediterranean diet and its health benefits in managing obesity

A possible link between aggregation of SARS-CoV-2 proteins and protein misfolding diseases

Researchers provide a framework for unifying and categorizing neurodegenerative diseases based on eight hallmarks

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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