BRCA1 Gene News and Research

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BRCA1 is a gene on chromosome 17 that normally helps to suppress cell growth. A person who inherits certain mutations (changes) in a BRCA1 gene has a higher risk of getting breast, ovarian, prostate, and other types of cancer.

Research uncovers cells-of-origin for breast cancer in BRCA2 mutation carriers

Australian scientists have pinpointed likely 'cells-of-origin', the source cells that can grow into breast cancer, in women carrying a faulty BRCA2 gene who are at high risk of developing the disease.

16 Jan 2024

Study finds link between epimutations in BRCA1 gene and triple-negative breast cancer risk

Research reveals that around 20 per cent of all cases of the most severe form of breast cancer may arise from the small group of normal tissue cells carrying an epimutation of a specific gene.

7 Dec 2023

New discovery sheds light on how BRCA1 mutations cause cancer in women

Three decades after discoveries linking mutations in the BRCA1 gene to breast and ovarian cancer susceptibility, research led by Mays Cancer Center at The University of Texas Health Science Center at San Antonio (UT Health San Antonio) has pinpointed the molecular mechanism by which a large portion of these mutations cause cancers in women.

9 Oct 2023

Progress and challenges in completing the human gene catalogue

A group of authors reviewed the progress and challenges in annotating the human genome, including protein-coding genes, isoforms, and non-coding RNAs, and advocated for a universal annotation standard for clinical use.

5 Oct 2023

Researchers highlight the importance of localizing BRCA gene mutations for better ovarian cancer treatment

Mutations of BRCA1 and BRCA2 genes, which are inherited by 1 in 400 and 1 in 800 people respectively, significantly increase the risk of certain cancers such as ovarian, breast, pancreatic and prostate cancer.

28 Nov 2022

Error-prone DNA replication and repair may lead to cancer in people with inherited BRCA1 mutations

Error-prone DNA replication and repair may lead to mutations and cancer in individuals who inherit a mutant copy of the BRCA1 gene, according to a new study by Weill Cornell Medicine investigators.

15 Nov 2022

Two new studies help improve the understanding of ovarian cancer

Two new discoveries led by Cedars-Sinai Cancer investigators help improve the understanding of what drives the development of ovarian cancer and why some women's tumors do not respond to therapy.

11 Oct 2022

Defective gene in blood cancers could be treated with already available drugs

A defective gene, normally found in blood cancers, could be treated with drugs already available for cancers with similar gene defects, scientists at Queen’s University Belfast and the University of Birmingham have revealed.

13 Jan 2022

Study explores therapeutic potential of exploiting autophagy cascade against COVID-19

Researchers recently reviewed current knowledge on links between autophagy and coronaviruses and how this knowledge can be used to repurpose autophagy modulators as potential treatment options for COVID-19. The review is published in the journal Frontiers in Microbiology.

7 Jun 2021

New atlas can help understand the relationship between healthy and breast cancer cells

Australian researchers have documented the diversity of cells in the human breast, explaining the relationship between healthy breast cells and breast cancer cells.

17 May 2021

First complete atlas of how mutations affect the formation of amyloid plaques in Alzheimer’s disease

A study published in the journal eLife made all the possible mutations in the amyloid beta peptide and tested how they influence its aggregation into plaques, a pathological hallmark of Alzheimer's disease.

9 Mar 2021

Better testing could lead to improved treatments for a specific type of ovarian cancer

Scientists have found that a specific type of ovarian cancer could possibly benefit from existing platinum-based chemotherapy and new DNA repairing treatments, following better testing.

8 Jun 2020

Researchers identify novel genetic signature with prognostic value for certain breast cancers

Researchers have identified a genetic signature with prognostic value for certain kinds of breast cancer. The discovery also contributes to a better understanding of the molecular mechanisms of pathological angiogenesis, the aberrant proliferation of blood vessels that occurs during cancer and other diseases.

17 Dec 2019

DNA methylation may influence the effects of aspirin in patients with breast cancer

Women with a particular DNA feature may live longer if they take aspirin even before they are diagnosed with breast cancer, a new study found.

13 Aug 2019

Bacteria in the birth canal linked to lower risk of ovarian cancer

A new study shows that something as simple as a cervical swab might have the potential to help hundreds of women who are at extremely high risk of ovarian cancer because they have a mutation in the BRCA1 gene.

11 Jul 2019

Scientists identify how cells make choice between various mechanisms to repair DNA

When DNA in the cell nucleus gets damaged, our cells can resort to a variety of repair mechanisms. A recent study published in 'Nature Cell Biology', to which scientists from Helmholtz Zentrum Muenchen made major contributions, elucidates the molecular basis by which a cell makes the choice between these repair mechanisms.

28 Feb 2019

BRCA1 Gene News and Research

Further Reading

Research uncovers cells-of-origin for breast cancer in BRCA2 mutation carriers

Study finds link between epimutations in BRCA1 gene and triple-negative breast cancer risk

New discovery sheds light on how BRCA1 mutations cause cancer in women

Progress and challenges in completing the human gene catalogue

Researchers highlight the importance of localizing BRCA gene mutations for better ovarian cancer treatment

Error-prone DNA replication and repair may lead to cancer in people with inherited BRCA1 mutations

Two new studies help improve the understanding of ovarian cancer

Defective gene in blood cancers could be treated with already available drugs

Study explores therapeutic potential of exploiting autophagy cascade against COVID-19

New atlas can help understand the relationship between healthy and breast cancer cells

First complete atlas of how mutations affect the formation of amyloid plaques in Alzheimer’s disease

Better testing could lead to improved treatments for a specific type of ovarian cancer

Researchers identify novel genetic signature with prognostic value for certain breast cancers

DNA methylation may influence the effects of aspirin in patients with breast cancer

Bacteria in the birth canal linked to lower risk of ovarian cancer

Scientists identify how cells make choice between various mechanisms to repair DNA

Scientists gain new insight into aggressive breast cancers

Polygenic screening could inform breast cancer risk in female survivors of pediatric cancer

Beyond BRCA: Epigenetic Silencing in Breast Cancer

New protein complex may explain why patients develop resistance to novel anti-cancer drugs

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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