Baclofen News and Research

RSS

Baclofen is a synthetic chlorophenyl-butanoic acid derivative used to treat spasms due to spinal cord damage and multiple sclerosis, muscle-relaxing Baclofen acts as a gamma-aminobutyric acid (GABA) agonist specific for GABA-B receptors. It acts at spinal and supraspinal sites, reducing excitatory transmission.

Which pharmacotherapies are associated with improved outcomes for people with alcohol use disorder?

Researchers assessed the efficacy and compared the relative effectiveness of various pharmacological treatments for alcohol use disorder.

8 Nov 2023

Special issue aims to deepen the conversation around cerebral palsy

Although cerebral palsy (CP) is the most common childhood-onset disability, there are very few evidence-based clinical practice guidelines or recommendations on how to treat and manage this condition.

31 May 2023

Study finds lack of high certainty evidence on the efficacy and safety of analgesics for low back pain

Despite nearly 60 years of research, there is still a lack of high certainty evidence on the effectiveness and safety of commonly used painkillers (analgesics) for short bouts of low back pain, finds an analysis of the evidence published by The BMJ.

23 Mar 2023

Study assesses the effect of transcutaneous spinal stimulation on intrathecal baclofen pump in patients with spinal cord injury

Researchers from Kessler Foundation and Kessler Institute for Rehabilitation (collectively "Kessler") conducted the first prospective study to assess whether transcutaneous spinal stimulation (TSS) interacts with implanted intrathecal baclofen (ITB) pump delivery systems for managing spasticity.

21 Mar 2023

Researchers assess the evidence basis for medications used to treat spine-related pain in older adults

Spine-related pain is increasingly common in older adults. While medications play an important role in pain management, their use has limitations in geriatric patients due to reduced liver and kidney function, comorbid medical problems and polypharmacy (the simultaneous use of multiple drugs to treat medical conditions).

28 Jun 2022

Study shows risk of MIS-C post mRNA vaccination against COVID-19 in children with autoimmune complications

Researchers discuss two cases of MIS-V after the patients had received the SARS-CoV-2 vaccine from Pfizer/BioNTech (BNT162b2).

23 Nov 2021

Experts assess the impact of COVID-19 on pediatric patients with special needs

The impact of the COVID-19 pandemic on children with disabilities has not received much attention, perhaps because the disease disproportionately affects older individuals.

4 Jan 2021

FEFU scientists suggest reconsidering existing treatment protocol for severe spinal cord trauma

Scientists from Far Eastern Federal University together with leading international experts suggest reconsidering the existing treatment protocol for severe spasticity, one of the main complications after spinal cord injury with partial spinal cord disruption.

10 Dec 2020

Common muscle relaxant linked to severe confusion in patients with kidney dysfunction

One in 25 patients with very low kidney function were admitted to hospital with severe confusion and other cognitive-related symptoms a few days after being prescribed a common muscle relaxant.

10 Nov 2019

Case study: Cannabinoid hyperemesis syndrome in a patient with ALS

This case study of a patient with ALS and symptoms of cannabinoid hyperemesis syndrome emphasizes the need for research into the use of medicinal cannabis.

12 Jun 2019

Study shows no difference between relief offered by topical pain creams and placebos

In an effort to reduce chronic pain, many people look for hope by paying $20 to thousands of dollars for a tube of prescription topical pain cream or gel.

6 Feb 2019

Compounded pain relief creams not effective finds study

A new study has shown that pain relief creams are no better than dummy or placebo creams when it comes to relieving pain.

6 Feb 2019

Study links molecular changes in the brain to key behaviors in addiction

Changes in a brain signaling system contribute to the development of alcohol addiction-like behaviors in rats, according to a new study led by researchers at Linköping University, Sweden.

25 Jun 2018

Long-term alcohol use changes brain functions differently in young men and women

Scientists have found that brain functions in young men and women are changed by long-term alcohol use, but that these changes are significantly different in men and women.

4 Sep 2017

Research reveals underlying reason for intense pain in patients with shingles

Chickenpox is a typical childhood illness. In most cases, it is benign, and the symptoms disappear within ten days. However, its causative agent, Varicella zoster virus (VZV), remains in the organism forever. In some cases, the virus can be reactivated years later, causing a different disease known as herpes zoster, or shingles.

24 Aug 2017

Baclofen has positive impact on alcohol consumption in patients with ALD

Results revealed today at The International Liver Congress 2015, show that in patients with alcohol-induced liver disease (ALD), Baclofen has a positive impact on alcohol consumption and overall measures of liver function and harm.

23 Apr 2015

Research to help patients suffering from severe spinal cord injuries

Many patients suffer from severe spinal cord injuries after being involved in traffic accidents or accidents at work.

5 Sep 2014

Alcoholic liver disease: an interview with Dr Vinood Patel, University of Westminster

Alcoholic liver disease (ALD) is one of the leading causes of death worldwide and also in the UK. As its name indicates this disease arises due to consuming excessive amounts of alcohol (80 g/day) over an extended period, normally 10-20 years.

24 Jun 2014

Form of baclofen works better at treating narcolepsy

Neuroscientists at SRI International have found that a form of baclofen, a drug used to treat muscle spasticity, works better at treating narcolepsy than the best drug currently available when tested in mice.

8 May 2014

Study finds that baclofen drug has potential to prevent cocaine relapse

Relapse is the most painful and expensive feature of drug addiction-even after addicted individuals have been drug-free for months or years, the likelihood of sliding back into the habit remains high. The National Institute on Drug Abuse estimates that 40 to 60 percent of addicted individuals will relapse, and in some studies the rates are as high as 80 percent at six months after treatment.

2 Apr 2014