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A biomarker is a biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. Also called molecular marker and signature molecule.
Researchers identify attractive drug candidate to target glioma tumors

Researchers identify attractive drug candidate to target glioma tumors

In a paper published today in Cancer Research, researchers: 1) identify a biomarker enzyme associated with aggressive glioma brain tumors, 2) reveal the regulatory mechanism for that enzyme, and 3) demonstrate potent efficacy, using a mouse model of glioma, for a small molecule inhibitor they have developed. [More]
Western diet during pregnancy may increase obesity risk in offspring

Western diet during pregnancy may increase obesity risk in offspring

Diet composition around the time of pregnancy may influence whether offspring become obese, according to a new study using animal models at The Scripps Research Institute (TSRI). [More]
Japanese researchers discover that 2-aminobutyric acid can effectively raise antioxidant levels

Japanese researchers discover that 2-aminobutyric acid can effectively raise antioxidant levels

A Japanese research team has become the first in the world to discover that 2-aminobutyric acid (2-AB) is closely involved in the metabolic regulation of the antioxidant glutathione, and that it can effectively raise levels of glutathione in the body when ingested. [More]
Antioxidant levels could be boosted with newly-found amino acid function

Antioxidant levels could be boosted with newly-found amino acid function

A Japanese research team has become the first in the world to discover that 2-aminobutyric acid (2-AB) is closely involved in the metabolic regulation of the antioxidant glutathione, and that it can effectively raise levels of glutathione in the body when ingested. The findings were published in the online version of Scientific Reports on November 9. [More]
New brain scan could act as diagnostic tool in Parkinson’s

New brain scan could act as diagnostic tool in Parkinson’s

A type of brain scan could act as a diagnostic tool in Parkinson’s according to a new study published in the scientific journal Radiology. [More]
Combatting Antibiotic Resistance, the role of POC Diagnostics

Combatting Antibiotic Resistance, the role of POC Diagnostics

During the winter months, patients frequently present with respiratory symptoms like coughing, sneezing and fever that could be caused by one of several bacterial and viral infections including influenza, respiratory syncytial virus (RSV) or bacterial pneumonia. [More]
New biomarker in cell-free blood plasma linked to overactive stress system in suicidal individuals

New biomarker in cell-free blood plasma linked to overactive stress system in suicidal individuals

Researchers at Lund and Malmö universities in Sweden have measured a biomarker in cell-free blood plasma which can be linked to an overactive stress system in suicidal individuals. This biomarker can hopefully be used in future psychiatric studies. [More]
Stem cell-based risk scoring tool could predict AML patient’s response to standard treatment

Stem cell-based risk scoring tool could predict AML patient’s response to standard treatment

Leukemia researchers at Princess Margaret Cancer Centre have developed a 17-gene signature derived from leukemia stem cells that can predict at diagnosis if patients with acute myeloid leukemia (AML) will respond to standard treatment. [More]
PITX2 methylation biomarker shows promise for predicting prostate cancer recurrence risk

PITX2 methylation biomarker shows promise for predicting prostate cancer recurrence risk

Prostate-specific antigen (PSA) and other biomarkers are essential tools for diagnosing and monitoring prostate cancer. [More]
Older women with metastatic breast cancer more likely to have genetic alterations in tumors

Older women with metastatic breast cancer more likely to have genetic alterations in tumors

A University of North Carolina Lineberger Comprehensive Cancer Center-led analysis has found that women who are 65 years or older with metastatic breast cancer were more likely to have a cancer-linked genetic alterations in their tumors, and had a larger total number of genetic alterations, than younger patients overall. [More]
Study detects biomarkers from secondhand marijuana smoke exposure in children

Study detects biomarkers from secondhand marijuana smoke exposure in children

Relaxing with a joint around children is not very wise. Not only do youngsters inhale harmful secondary smoke in the process, but the psychoactive chemicals in the drug are taken up by their bodies as well. [More]
New chemosensor offers better sensitivity in detecting biomarker for cancer and inflammatory diseases

New chemosensor offers better sensitivity in detecting biomarker for cancer and inflammatory diseases

A new technique offers better sensitivity and accuracy in detecting an essential biomarker of cancer and inflammatory diseases. [More]
Detecting inflammation in diabetic patients

Detecting inflammation in diabetic patients

As well as presenting with high blood glucose, diabetic patients have chronic low-grade inflammation, which can be measured by a range of inflammatory markers such as so-called high-sensitive CRP, TNFa and IL-6 as well as a full blood cell count. [More]
PD-1 protein could serve as biomarker for predicting survival of lung cancer patients

PD-1 protein could serve as biomarker for predicting survival of lung cancer patients

The biomarker PD-1, a protein, could potentially be used to predict survival or disease-free survival of lung cancer patients who have had the tumour surgically removed. [More]
Scientists discover new biomarker to help determine aggressiveness of brain cancer

Scientists discover new biomarker to help determine aggressiveness of brain cancer

Researchers at UT Southwestern Medical Center have found a new biomarker for glioma, a common type of brain cancer, that can help doctors determine how aggressive a cancer is and that could eventually help determine the best course of treatment. [More]
Combination treatment produces better outcomes in erythropoietin-refractory MDS patients, study shows

Combination treatment produces better outcomes in erythropoietin-refractory MDS patients, study shows

Patients with myelodysplastic syndromes (MDS) suffer from a reduction in the number of different types of blood cells, including red blood cells leading to the development of anemia. [More]
Clonal hematopoiesis may help predict cancer patients at risk for fatal form of leukemia

Clonal hematopoiesis may help predict cancer patients at risk for fatal form of leukemia

Patients successfully treated for breast, colon and other cancers can go on to develop an often-fatal form of leukemia, sometimes years after completion of treatment, due to a genetic mutation leading to secondary malignancies known as therapy-related myeloid neoplasms (t-MNs). [More]
Researchers show how microRNAs play key role in tumor progression and response to radiation

Researchers show how microRNAs play key role in tumor progression and response to radiation

OHSU researcher Sudarshan Anand, Ph.D., has a contemporary analogy to describe microRNA: "I sometimes compare MicroRNA to tweets -- they're short, transient and constantly changing." [More]
Applying quantitative microscopy to live cells

Applying quantitative microscopy to live cells

Microscopy's got a long history. It was developed about 350 years ago for scientists to visualize things they could discern, but not describe. The two pioneers of microscopy were Antoine van Leeuwenhoek, who developed the first microscope and soon after the renowned scientist, Robert Hooke. [More]
NSF awards grant to advance new diagnostic test for fatal gastrointestinal disease in pre-term infants

NSF awards grant to advance new diagnostic test for fatal gastrointestinal disease in pre-term infants

The National Science Foundation has chosen an LSU Health New Orleans team that developed a test for the early detection of a potentially life-threatening gastrointestinal disease affecting pre-term, low birthweight babies to receive expert guidance to move the technology forward. [More]
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