Biomarker News and Research

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A biomarker is a biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. Also called molecular marker and signature molecule.

OracleBio to highlight Oncology image analysis expertise at Tumor Models conference

OracleBio, providers of high precision digital image analysis services for detailed quantification of histological marker staining within cells and tissues, is pleased to announce it will be a principal sponsor of the forthcoming Tumor Models conference to be held in Boston, MA on the 23-25th July.

24 Jul 2013

Child cancer survival: an interview with Prof Kathy Pritchard-Jones, University College London

Back in the early 1960s, just before chemotherapy really started to be used, only about 30% of children survived cancer. That was mainly because they had cancers that were amenable to surgery.

24 Jul 2013

Digital versions of standard molecular biology tool to detect common tumor-associated mutation in CSF

Massachusetts General Hospital (MGH) researchers and their colleagues have used digital versions of a standard molecular biology tool to detect a common tumor-associated mutation in the cerebrospinal fluid (CSF) of patients with brain tumors. In their report being published in the open-access journal Molecular Therapy - Nucleic Acids, the investigators describe using advanced forms of the gene-amplification technology polymerase chain reaction (PCR) to analyze bits of RNA carried in membrane-covered sacs called extracellular vesicles for the presence of a tumor-associated mutation in a gene called IDH1.

24 Jul 2013

Fibromyalgia diagnosis: an interview with Dr. Bruce Gillis, CEO of EpicGenetics

Presently, it is a diagnosis of exclusion. Patients end up spending, according to what’s been published in the medical literature, as many as 3 - 5 years going from doctor to doctor seeking a diagnosis because they tend to have nonspecific symptoms of a subjective nature.

23 Jul 2013

Array BioPharma announces positive results from ARRY-502 Phase 2 trial for allergic asthma

Array BioPharma Inc. today announced positive results from a placebo-controlled, randomized, double‑blind Phase 2 trial in mild to moderate persistent allergic asthma for ARRY-502, an oral CRTh2 antagonist.

23 Jul 2013

Primer provides physicians with current approaches to diagnose and manage concussions in patients

Concussions, the most common traumatic brain injury, can have serious long-term health effects; therefore, diagnosis and management of these injuries are important. A primer published in CMAJ (Canadian Medical Association Journal) provides physicians with current approaches to diagnosing and managing concussions in patients.

23 Jul 2013

Computerized cognitive testing plays a key role in therapy development for dementia, AD

Computerized cognitive testing is increasingly playing a key role in therapy development for dementia and Alzheimer's disease. This week at the Alzheimer's Association International Conference, Keith Wesnes Ph.D., Practice Leader of Bracket and founder of the CDR System-, discussed new data for novel therapies at two poster presentations at the Alzheimer's Association International Conference.

19 Jul 2013

OGT produces free-to-download whitepaper on targeted resequencing strategies

Oxford Gene Technology, provider of innovative genetics research and biomarker solutions to advance molecular medicine, has produced a new, free-to-download whitepaper titled ‘When to use targeted resequencing — Choosing the right NGS method.’

From Oxford Gene Technology 17 Jul 2013

Cell therapies may stop or reverse pain and disability of degenerative disc disease

Cell therapies may stop or reverse the pain and disability of degenerative disc disease and the loss of material between vertebrae, according to Duke University scientists.

17 Jul 2013

Weill Cornell reports new findings from IVIG Phase 3 trial in Alzheimer's disease at AAIC 2013

Weill Cornell Medical College neurologist Dr. Norman Relkin reported new findings today from the Phase 3 clinical trial of IVIG (intravenous immunoglobulin) in mild to moderate Alzheimer's disease at the Alzheimer's Association International Conference in Boston, Mass.

16 Jul 2013

Accumulation of plaques in brain may serve as powerful biomarker for early detection of cognitive decline

The trajectory of amyloid plaque buildup-clumps of abnormal proteins in the brain linked to Alzheimer's disease-may serve as a more powerful biomarker for early detection of cognitive decline rather than using the total amount to gauge risk, researchers from Penn Medicine's Department of Radiology suggest in a new study published online July 15 in Neurobiology of Aging.

16 Jul 2013

C2N Diagnostics, CIL sign collaborative research and global supplier agreement

C2N Diagnostics today announced that it has signed a collaborative research and a global, exclusive supplier agreement with Cambridge Isotope Laboratories, Inc. The partnership guarantees C2N's future access to mass quantities of highly enriched stable isotopes at predictable prices.

12 Jul 2013

Alnylam releases positive top-line data from ALN-TTRsc Phase I trial for TTR-mediated amyloidosis

Alnylam Pharmaceuticals, Inc., a leading RNAi therapeutics company, announced today positive top-line results from its ongoing Phase I trial of ALN-TTRsc, a subcutaneously administered RNAi therapeutic targeting the transthyretin gene for the treatment of TTR-mediated amyloidosis.

12 Jul 2013

Researchers develop new tool for comprehensive mapping of cell-cell communication

Researchers at Memorial Sloan-Kettering Cancer Center, together with collaborators in Germany, have developed a new method for identifying the cell of origin of intracellular and secreted proteins within multicellular environments.

11 Jul 2013

Children diagnosed with autism have excessive cerebrospinal fluid and enlarged brains in infancy

Children who were later diagnosed with autism spectrum disorder had excessive cerebrospinal fluid and enlarged brains in infancy, a study by a multidisciplinary team of researchers with the UC Davis MIND Institute has found, raising the possibility that those brain anomalies may serve as potential biomarkers for the early identification of the neurodevelopmental disorder.

11 Jul 2013

Study shows disrupted micronuclei may prove to be a valuable tool for detecting cancer

Scientists studying cancer development have known about micronuclei for some time. These erratic, small extra nuclei, which contain fragments or whole chromosomes that were not incorporated into daughter cells after cell division, are associated with specific forms of cancer and are predictive of poorer prognosis.

10 Jul 2013

Boehringer Ingelheim signs multi-year renewal agreement to NextBio Research Platform

NextBio, whose Big Data technology enables users to apply genomic data from disparate sources in novel and useful ways across life sciences research, today announced that Boehringer Ingelheim has signed a multi-year renewal agreement to the NextBio Research Platform.

9 Jul 2013

Biomarker News and Research

Further Reading

OracleBio to highlight Oncology image analysis expertise at Tumor Models conference

Child cancer survival: an interview with Prof Kathy Pritchard-Jones, University College London

Digital versions of standard molecular biology tool to detect common tumor-associated mutation in CSF

Fibromyalgia diagnosis: an interview with Dr. Bruce Gillis, CEO of EpicGenetics

Array BioPharma announces positive results from ARRY-502 Phase 2 trial for allergic asthma

Primer provides physicians with current approaches to diagnose and manage concussions in patients

Computerized cognitive testing plays a key role in therapy development for dementia, AD

OGT produces free-to-download whitepaper on targeted resequencing strategies

Cell therapies may stop or reverse pain and disability of degenerative disc disease

Weill Cornell reports new findings from IVIG Phase 3 trial in Alzheimer's disease at AAIC 2013

Accumulation of plaques in brain may serve as powerful biomarker for early detection of cognitive decline

C2N Diagnostics, CIL sign collaborative research and global supplier agreement

Alnylam releases positive top-line data from ALN-TTRsc Phase I trial for TTR-mediated amyloidosis

Researchers develop new tool for comprehensive mapping of cell-cell communication

Children diagnosed with autism have excessive cerebrospinal fluid and enlarged brains in infancy

Study shows disrupted micronuclei may prove to be a valuable tool for detecting cancer

Boehringer Ingelheim signs multi-year renewal agreement to NextBio Research Platform

Disrupted micronuclei might play more active role in carcinogenesis, new study finds

Leica Biosystems announces acquisition of Kreatech Diagnostics

Researchers discover potential biomarkers that track progression of neurodegenerative disease

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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