Biomarker News and Research

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A biomarker is a biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. Also called molecular marker and signature molecule.

Study shows disrupted micronuclei may prove to be a valuable tool for detecting cancer

Scientists studying cancer development have known about micronuclei for some time. These erratic, small extra nuclei, which contain fragments or whole chromosomes that were not incorporated into daughter cells after cell division, are associated with specific forms of cancer and are predictive of poorer prognosis.

10 Jul 2013

Boehringer Ingelheim signs multi-year renewal agreement to NextBio Research Platform

NextBio, whose Big Data technology enables users to apply genomic data from disparate sources in novel and useful ways across life sciences research, today announced that Boehringer Ingelheim has signed a multi-year renewal agreement to the NextBio Research Platform.

9 Jul 2013

Disrupted micronuclei might play more active role in carcinogenesis, new study finds

9 Jul 2013

Leica Biosystems announces acquisition of Kreatech Diagnostics

Leica Biosystems announced that it has acquired Kreatech Diagnostics, a privately-held provider of DNA fluorescent in-situ hybridization probes and target labeling reagents for microarrays.

9 Jul 2013

Researchers discover potential biomarkers that track progression of neurodegenerative disease

A hallmark of neurodegenerative diseases such as Alzheimer's, Parkinson's and Huntington's is that by the time symptoms appear, significant brain damage has already occurred-and currently there are no treatments that can reverse it.

9 Jul 2013

Soligenix announces personalized medicine collaboration with SciClone

Soligenix, Inc., a clinical stage biopharmaceutical company focused on developing products to treat inflammatory diseases and biodefense countermeasures where there remains an unmet medical need, announced a personalized medicine collaboration with SciClone Pharmaceuticals in the Company's oral mucositis clinical program with SGX942.

8 Jul 2013

Study describes how human mammary gland becomes highly sensitive to insulin during lactation

Why do so many mothers have difficulty making enough milk to breastfeed? A new study by scientists at Cincinnati Children's Hospital Medical Center and the University of California Davis adds to their previous research implicating insulin's role in lactation success.

6 Jul 2013

New study finds inherited genetic contribution in autism with intellectual disability

Researchers are striving to understand the different genetic structures that underlie at least a subset of autism spectrum disorders. In cases where the genetic code is in error, did that happen anew in the patient, perhaps through mutation or copying error, or was it inherited? A new study in the American Journal of Human Genetics finds evidence that there may often be a recessive, inherited genetic contribution in autism with significant intellectual disability.

4 Jul 2013

GAPVAC aims to develop personalized therapeutic vaccines for cancer

A highly innovative project supported by a €6 million European Union Framework 7 (EU FP7) program grant to develop a novel class of therapeutic cancer vaccines is now under way.

4 Jul 2013

3-gene signature test will improve care of kidney transplant patients

A breakthrough non-invasive test can detect whether transplanted kidneys are in the process of being rejected, as well as identify patients at risk for rejection weeks to months before they show symptoms, according to a study published in The New England Journal of Medicine (NEJM).

4 Jul 2013

Prosigna Breast Cancer Prognostic Gene Signature Assay study published in JCO

NanoString Technologies, Inc., a provider of life science tools for translational research and molecular diagnostic products, today announced that the TransATAC clinical validation study for its Prosigna Breast Cancer Prognostic Gene Signature Assay, which is based on the PAM50 gene signature, was published in the Journal of Clinical Oncology.

From NanoString Technologies 2 Jul 2013

Alnylam Pharmaceuticals presents new pre-clinical data of ALN-AT3 at ISTH meeting

Alnylam Pharmaceuticals, Inc., a leading RNAi therapeutics company, announced today that it has presented new pre-clinical data from its RNAi therapeutic program for the treatment of hemophilia and rare bleeding disorders.

2 Jul 2013

UNC scientists use GEMMs to develop biomarkers for molecular subtypes of human breast cancer

It's a GEMM of a system. Genetically engineered mouse models that is. Using them allows scientists to study cancer in a way that more naturally mimics how human tumors exist within the complex environment of the body.

2 Jul 2013

Researchers use two new methods to detect levels of ALK protein expression in NSCLC

The implementation of personalized health care in cancer relies on the identification and characterization of cancer biomarkers and the availability of accurate detection systems and therapies for those biomarkers.

2 Jul 2013

HDAC10 gene plays a key role in autophagy and resistance to chemotherapy in high-risk neuroblastomas

Neuroblastomas are pediatric tumors that originate from cells of the embryonic nervous system. The disease can take widely varying clinical courses that range from spontaneous regression to fatal outcomes.

2 Jul 2013

Genentech's Perjeta regimen gets FDA Priority Review for HER2-positive early stage breast cancer

Genentech, a member of the Roche Group, today announced that the U.S. Food and Drug Administration has accepted the company's supplemental Biologics License Application for the use of a Perjeta (pertuzumab) regimen before surgery (neoadjuvant treatment) in people with HER2-positive early stage breast cancer.

2 Jul 2013

Biomarker indicates which women are at risk for breast cancer recurrence after tamoxifen

A biomarker reflecting expression levels of two genes in tumor tissue may be able to predict which women treated for estrogen-receptor (ER)-positive breast cancer should receive a second estrogen-blocking medication after completing tamoxifen treatment.

30 Jun 2013

New procedure to treat acid reflux can prevent chronic rejection in lung transplant patients

A Loyola University Medical Center study suggests that a procedure to treat acid reflux could help prevent chronic rejection in lung transplant patients.

30 Jun 2013

Study suggests amylin deposits are a new biomarker for age-related dementia and Alzheimer's

A second amyloid may play a role in Alzheimer's disease, UC Davis researchers find. A protein secreted with insulin travels through the bloodstream and accumulates in the brains of individuals with type 2 diabetes and dementia, in the same manner as the amyloid beta (Αβ) plaques that are associated with Alzheimer's disease, a study by researchers with the UC Davis Alzheimer's Disease Center has found.

28 Jun 2013

Researchers say genetics and life experience independently protect against cognitive decline in MS

U.S. and Italian researchers have determined that brain reserve, as well as cognitive reserve, independently protects against cognitive decline in multiple sclerosis (MS). Their article, "Brain reserve and cognitive reserve in multiple sclerosis: What you've got and how you use it", was published in Neurology on June 11, 2013.

26 Jun 2013

Biomarker News and Research

Further Reading

Study shows disrupted micronuclei may prove to be a valuable tool for detecting cancer

Boehringer Ingelheim signs multi-year renewal agreement to NextBio Research Platform

Disrupted micronuclei might play more active role in carcinogenesis, new study finds

Leica Biosystems announces acquisition of Kreatech Diagnostics

Researchers discover potential biomarkers that track progression of neurodegenerative disease

Soligenix announces personalized medicine collaboration with SciClone

Study describes how human mammary gland becomes highly sensitive to insulin during lactation

New study finds inherited genetic contribution in autism with intellectual disability

GAPVAC aims to develop personalized therapeutic vaccines for cancer

3-gene signature test will improve care of kidney transplant patients

Prosigna Breast Cancer Prognostic Gene Signature Assay study published in JCO

Alnylam Pharmaceuticals presents new pre-clinical data of ALN-AT3 at ISTH meeting

UNC scientists use GEMMs to develop biomarkers for molecular subtypes of human breast cancer

Researchers use two new methods to detect levels of ALK protein expression in NSCLC

HDAC10 gene plays a key role in autophagy and resistance to chemotherapy in high-risk neuroblastomas

Genentech's Perjeta regimen gets FDA Priority Review for HER2-positive early stage breast cancer

Biomarker indicates which women are at risk for breast cancer recurrence after tamoxifen

New procedure to treat acid reflux can prevent chronic rejection in lung transplant patients

Study suggests amylin deposits are a new biomarker for age-related dementia and Alzheimer's

Researchers say genetics and life experience independently protect against cognitive decline in MS

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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