Biomarker News and Research

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A biomarker is a biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. Also called molecular marker and signature molecule.

LDL cholesterol blood level declines found to have abruptly ended in 2008

Decades of declines in LDL cholesterol blood levels, a key marker of death risk from heart disease, abruptly ended in 2008, and may have stalled since, according to a multi-year, national study published in PLOS ONE.

From Quest Diagnostics 14 May 2013

Study suggests that a blood protein contributes to early development of atherosclerosis

It's on Saturday that the Journal of the American Heart Association published the conclusive results from a study directed by Dr. Éric Thorin of the Montreal Heart Institute (MHI), which suggests for the first time that a blood protein contributes to the early development of atherosclerosis.

14 May 2013

Cancers physically alter cells in lymphatic system to promote the spread of disease

Researchers at the University of California, San Diego School of Medicine and UC San Diego Moores Cancer Center report that cancers physically alter cells in the lymphatic system - a network of vessels that transports and stores immune cells throughout the body - to promote the spread of disease, a process called metastasis.

14 May 2013

New British technologies are transforming healthcare and saving lives

Innovative projects including: smart-phone test and tracking systems for infectious diseases; fibre optic probes that can monitor people's condition in intensive care; and in-home sensors that can relay patient information to doctors immediately, have benefitted from a -32 million investment.

10 May 2013

ALS-ETF, Denovo partner to explore personalized medicine approach for ALS

The ALS Emergency Treatment Fund and Denovo Biomarkers have announced a partnership to explore using Denovo's technology to identify potential responder groups for drugs being studied in ALS patients.

10 May 2013

Clinical study predicting risk of near-term MI and death in CAD patients to be published in JACC

FirstMark, a division of GenWay Biotech that is focused on developing and commercializing noninvasive diagnostic and health monitoring tests for unmet clinical needs, today announced that results from the break-through proof-of-concept clinical study, performed in collaboration with Emory University and MedStar Washington Hospital Center, will be published in the Journal of the American College of Cardiology.

9 May 2013

Exosome Diagnostics' urine exosome technology accurately predicts outcome of prostate biopsy

Exosome Diagnostics, a leading developer of biofluid-based molecular diagnostic products for use in personalized medicine research and clinical diagnostics, today announced the presentation of data at the American Urological Association Annual Meeting in San Diego demonstrating the performance of urine exosome technology in accurately predicting the outcome of a prostate biopsy.

9 May 2013

Study shows patient selection based on biosamples makes clinical trials more efficient, reduces costs

Researchers at Moffitt Cancer Center say identifying and selecting participants for phase II cancer clinical trials from a centralized warehouse of patient-donated biological data expedites participant accrual, reduces trial size, saves money, and may speed test drugs through the drug development pipeline.

8 May 2013

Testing Stat5 gene amplification in prostate cancer patients could provide powerful therapy: Study

An international group of investigators, led by researchers at Thomas Jefferson University's Kimmel Cancer Center, have solved the mystery of why a substantial percentage of castrate-resistant metastatic prostate cancer cells contain abnormally high levels of the pro-growth protein Stat5.

8 May 2013

Anavex invited to submit funding application for Phase 2a trial of ANAVEX 2-73

Anavex Life Sciences Corp. ("Anavex") (OTCQB: AVXL) today announced that it has been invited to submit a full grant application to the Alzheimer's Drug Discovery Foundation ("ADDF") for a Phase 2a trial of ANAVEX 2-73.

7 May 2013

Neuroperspective reviews status and prospects of therapeutics for Parkinson's disease

NI Research, the leading publisher of independent research on the neurotherapeutics industry, has released the May issue of NeuroPerspective, which reviews the status and prospects of therapeutics for Parkinson's.

7 May 2013

PCEC releases statement on AUA's new prostate cancer clinical practice guidelines

The Prostate Conditions Education Council, a national organization committed to men's health and a leader in prostate cancer early detection, released the following statement in response to new clinical practice guideline released today by the American Urological Association.

5 May 2013

DVS Sciences announces introduction of new products for single cell analysis

DVS Sciences, Inc., a privately held innovator of novel multi-parameter single-cell analyzers and reagents for biological research, today announced the introduction of the new CyTOF 2 Mass Cytometer and new MaxPar Panel Kits designed specifically for simultaneous high-parameter single cell analysis.

4 May 2013

Measurement variation influences gene expression profiles of breast cancer

An important new study has revealed the clearest picture yet of precisely how much measurement variation influences gene expression profiles of breast cancer.

3 May 2013

Adrenomedullin plays a crucial role in preventing preeclampsia

In a study using mice, researchers from the University of North Carolina at Chapel Hill found that a hormone, adrenomedullin, plays a crucial role in preventing the pregnancy complication preeclampsia.

2 May 2013

Study brings opportunities of personalised therapy for breast cancer a step closer

A study led by prominent breast cancer experts from Europe and the US has revealed a number of potentially important prospects for targeted therapies, and brings opportunities of truly personalised therapy for breast cancer a step closer, researchers said at the 5th IMPAKT Breast Cancer Conference in Brussels, Belgium.

2 May 2013

Prosigna Breast Cancer Prognostic Gene Signature Assay predicts ROR in women with early-stage breast cancer

NanoString Technologies, Inc., a privately held provider of life science tools for translational research and molecular diagnostic products, today announced results from two studies that are featured in oral presentations this week at IMPAKT Breast Cancer Conference.

2 May 2013

Researchers find that VEGF may not have any prognostic value for advanced prostate cancer

The well-studied protein VEGF does not appear to have any prognostic or predictive value for men with locally advanced prostate cancer, researchers from the Department of Radiation Oncology at Thomas Jefferson University Hospital and other institutions found in a retrospective study published online April 25 in the journal BMC Radiation Oncology.

30 Apr 2013

Analysis identifies 37 RNA molecules that might predict survival in breast cancer patients

A Big Data analysis that integrates three large sets of genomic data available through The Cancer Genome Atlas has identified 37 RNA molecules that might predict survival in patients with the most common form of breast cancer.

30 Apr 2013

IP-10 and neopterin show promise as biomarkers for lung disease exacerbations

Australian researchers have identified interferon-γ inducible protein-10 and neopterin as promising sputum markers of acute exacerbations of obstructive lung disease.

29 Apr 2013

Biomarker News and Research

Further Reading

LDL cholesterol blood level declines found to have abruptly ended in 2008

Study suggests that a blood protein contributes to early development of atherosclerosis

Cancers physically alter cells in lymphatic system to promote the spread of disease

New British technologies are transforming healthcare and saving lives

ALS-ETF, Denovo partner to explore personalized medicine approach for ALS

Clinical study predicting risk of near-term MI and death in CAD patients to be published in JACC

Exosome Diagnostics' urine exosome technology accurately predicts outcome of prostate biopsy

Study shows patient selection based on biosamples makes clinical trials more efficient, reduces costs

Testing Stat5 gene amplification in prostate cancer patients could provide powerful therapy: Study

Anavex invited to submit funding application for Phase 2a trial of ANAVEX 2-73

Neuroperspective reviews status and prospects of therapeutics for Parkinson's disease

PCEC releases statement on AUA's new prostate cancer clinical practice guidelines

DVS Sciences announces introduction of new products for single cell analysis

Measurement variation influences gene expression profiles of breast cancer

Adrenomedullin plays a crucial role in preventing preeclampsia

Study brings opportunities of personalised therapy for breast cancer a step closer

Prosigna Breast Cancer Prognostic Gene Signature Assay predicts ROR in women with early-stage breast cancer

Researchers find that VEGF may not have any prognostic value for advanced prostate cancer

Analysis identifies 37 RNA molecules that might predict survival in breast cancer patients

IP-10 and neopterin show promise as biomarkers for lung disease exacerbations

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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