Bisphosphonate News and Research

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Bisphosphonate is a drug or substance used to treat hypercalcemia (abnormally high blood calcium) and bone pain caused by some types of cancer. Forms of bisphosphonates are also used to treat osteoporosis and for bone imaging. Bisphosphonates inhibit a type of bone cell that breaks down bone. Also called diphosphonate.

Exploring the dual role of nirmatrelvir and bisphosphonates in COVID-19 treatment and immunity

Review examines nirmatrelvir and bisphosphonates in treating COVID-19, revealing their impact on SARS-CoV-2-specific adaptive immunity and potential to mitigate severe infections, highlighting the need for balanced long-term immunity management.

16 Nov 2023

Researchers reveal mechanism by which MAF protein increases metastasis risk in breast cancer patients

Breast cancer is the most common form of cancer among women, with more than 2 million new cases diagnosed each year. In cases where the tumour remains localised in the breast, survival rates are remarkably high, at around 90%.

9 Nov 2023

Study highlights a promising therapy to mitigate spaceflight-induced bone loss

A new study published in a Nature Partner Journal, npj Microgravity, finds an engineered compound given to mice aboard the International Space Station (ISS) largely prevented the bone loss associated with time spent in space.

18 Sep 2023

COVID-19 pandemic fails to deter osteoporosis treatment initiation: New study reveals steady rates

Whether patients with newly diagnosed osteoporosis received delayed pharmacologic treatment due to the COVID-19 pandemic.

18 Sep 2023

$Patients prescribed corticosteroids less likely to receive fracture preventive care$

Patients prescribed corticosteroids less likely to receive fracture preventive care

Prolonged use of corticosteroids, such as prednisolone, has been shown to cause osteoporosis and therefore increases the risk of breaking a bone.

10 Aug 2023

Testing whether osteoporosis drugs plus “bone-loading” exercises can help older adults to safely lose weight

A $7 million study beginning this summer at Wake Forest University and Wake Forest University School of Medicine will help determine whether a combination of resistance training plus bone-strengthening exercises and/or osteoporosis medication use can help older adults safely lose weight without sacrificing bone mass.

30 Jun 2023

Experts provide first framework for treating hypercalcemia of malignancy in adults

Experts provide the first framework for treating a common and life-threatening metabolic complication of cancer known as hypercalcemia of malignancy in the Endocrine Society's new Clinical Practice Guideline.

21 Dec 2022

Bisphosphonates appear to improve COVID-19 exposure outcomes

A new retrospective study examines the effect of bisphosphonates on COVID-19 outcomes.

27 Jun 2022

New antibody conjugate delivers drugs to bone tumors and inhibits metastasis

Bone cancer is hard to treat and prone to metastasis. Research teams at Rice University and Baylor College of Medicine have a new strategy to attack it.

23 Jun 2021

Women with osteoporosis and low bone density have higher risk of hearing loss

Hearing loss is the third most common chronic health condition in the United States. Previous studies of people with hearing loss have uncovered higher prevalence of osteoporosis -- a disease in which the bones become weak and brittle -- and low bone density (LBD).

25 May 2021

$Researchers develop new method to regenerate bone and heal severe fractures$

Researchers develop new method to regenerate bone and heal severe fractures

Researchers at Lund University in Sweden, in collaboration with colleagues in Dresden, Germany, have developed a way of combining a bone substitute and drugs to regenerate bone and heal severe fractures in the thigh or shin bone.

19 Jan 2021

$Incidence of osteoporotic hip fractures expected to escalate in some Eurasian countries$

Incidence of osteoporotic hip fractures expected to escalate in some Eurasian countries

A detailed analysis of the burden of osteoporosis in eight Eurasian countries has found that osteoporosis is a significant and growing health problem in the region that will escalate in the future due to expected demographic changes.

12 Jan 2021

$Study identifies link between hip fracture risk and nanoscale bone inflexibility$

Study identifies link between hip fracture risk and nanoscale bone inflexibility

The study led by Imperial College London found that flexibility, as well as density, in the bone nanostructure is an important factor in assessing how likely someone is to suffer fractures.

26 Aug 2020

$Prolonged use of bisphosphonates increases risk of atypical femur fractures$

Prolonged use of bisphosphonates increases risk of atypical femur fractures

The risk of atypical femur fractures increases with prolonged use of bisphosphonates, drugs commonly used to treat osteoporosis, according to a new study.

24 Aug 2020

Bisphosphonates may be safe and beneficial for osteoarthritis patients

Bisphosphonates (a class of drugs that prevent the loss of bone density and used to treat osteoporosis and similar diseases) appear to be safe and beneficial for osteoarthritis patients.

5 Aug 2020

$Researchers examine the implications of bisphosphonate drug holidays on fracture risk$

Researchers examine the implications of bisphosphonate drug holidays on fracture risk

Bisphosphonates have been shown to reduce the risk of osteoporotic fractures. To avoid possible side effects of long-term therapy, many patients take a drug holiday after several years of bisphosphonate therapy.

29 Jul 2020

New guidance released for treating patients with osteoporosis during COVID-19 crisis

The Endocrine Society joined a coalition of leading bone health organizations to release guidance for healthcare professionals treating patients with osteoporosis in the era of COVID-19.

8 May 2020

Osteoporosis drugs associated with reduced risk of premature mortality

Two studies led by the Garvan Institute of Medical Research have revealed that nitrogen-bisphosphonates, drugs commonly prescribed for osteoporosis, reduced the risk of premature mortality by 34% in a cohort of over 6,000 individuals.

13 Aug 2019

Benefits of osteoporosis treatment in postmenopausal women outweigh the perceived risks

The benefits of treating osteoporosis in postmenopausal women outweigh the perceived risks, according to a Clinical Practice Guideline issued today by the Endocrine Society. The Society introduced the guideline during a news conference on Monday at ENDO 2019, its annual meeting in New Orleans, La.

25 Mar 2019

Bisphosphonates to treat osteoporosis appears to be beneficial for all women

In recent years, women who start taking bisphosphonates to treat osteoporosis and prevent fracture have trended from younger to older and from having osteopenia to having osteoporosis, researchers report.