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Blood sugar concentration, or glucose level, refers to the amount of glucose present in the blood of a human or animal. Normally, in mammals the blood glucose level is maintained at a reference range between about 3.6 and 5.8 mM (mmol/l). It is tightly regulated as a part of metabolic homeostasis.
Annual diabetic retinopathy screening for children with type 1 diabetes should begin at later age, study says

Annual diabetic retinopathy screening for children with type 1 diabetes should begin at later age, study says

A new study has found that the occurrence of advanced forms of a diabetic eye disease remains low among children living with diabetes, regardless of how long they have had the disease or their ability to keep blood sugar levels controlled. Researchers are therefore recommending that most children with type 1 diabetes delay annual diabetic retinopathy screenings until age 15, or 5 years after their diabetes diagnosis, whichever occurs later. [More]
Proportion of diabetes patients undergoing coronary artery bypass grafting rises from 7% to 37% in 40 years

Proportion of diabetes patients undergoing coronary artery bypass grafting rises from 7% to 37% in 40 years

In the 40 years between 1970-2010, the proportion of patients with diabetes undergoing coronary artery bypass grafting (CABG) escalated from 7% to 37%. The results of a large study from Cleveland Clinic just published in The Journal of Thoracic and Cardiovascular Surgery, the official publication of the American Association for Thoracic Surgery, documents the five-fold increase in the proportion of patients with diabetes undergoing this procedure between 1970 and 2010. [More]
Breakthrough antibody therapy shows significant promise against drug-resistant multiple myeloma

Breakthrough antibody therapy shows significant promise against drug-resistant multiple myeloma

In its first clinical trial, a breakthrough antibody therapy produced at least partial remissions in a third of patients with multiple myeloma who had exhausted multiple prior treatments, investigators at Dana-Farber Cancer Institute and other organizations report today online in the New England Journal of Medicine. [More]
Dexcom G5 Mobile Continuous Glucose Monitoring System receives FDA approval

Dexcom G5 Mobile Continuous Glucose Monitoring System receives FDA approval

Dexcom, Inc., a leader in continuous glucose monitoring (CGM) for patients with diabetes, announced today that the U.S. Food and Drug Administration has approved the Dexcom G5 Mobile Continuous Glucose Monitoring (CGM) System. [More]
High blood sugar may reduce positive effects of exercise on bone health in diabetic patients

High blood sugar may reduce positive effects of exercise on bone health in diabetic patients

Diabetes, which now affects almost 30 million Americans, can cause serious health complications, including heart disease, blindness, kidney failure and lower-extremity amputations. [More]
EMPA-REG OUTCOME trial demonstrates superiority of Jardiance in T2D patients at risk for CV events

EMPA-REG OUTCOME trial demonstrates superiority of Jardiance in T2D patients at risk for CV events

Boehringer Ingelheim and Eli Lilly and Company today announced positive top-line results from EMPA-REG OUTCOME. This is a long-term clinical trial investigating cardiovascular (CV) outcomes for Jardiance (empagliflozin) in more than 7,000 adults with type 2 diabetes (T2D) at high risk for CV events. [More]
NIH-funded Growing Resilience project to evaluate health impacts of food gardens

NIH-funded Growing Resilience project to evaluate health impacts of food gardens

With a five-year, $2.5 million grant from the National Institutes of Health, University of Wyoming and Wind River Indian Reservation partners will evaluate the health impacts of food gardens with 100 Eastern Shoshone and Northern Arapaho families who would like to try home gardening. [More]
Study reports results of genetic testing for 22 genetic causes of neonatal diabetes

Study reports results of genetic testing for 22 genetic causes of neonatal diabetes

Over a 10 year period, the time that babies receive genetic testing after being diagnosed with diabetes has fallen from over four years to under two months. Pinpointing the exact genetic causes of sometimes rare forms of diabetes is revolutionising healthcare for these patients. [More]
Eating too many refined carbohydrates may increase depression risk

Eating too many refined carbohydrates may increase depression risk

A study published this week indicates that a diet high in refined carbohydrates may increase the risk of developing depression. [More]
Study may lead to effective antimicrobial treatment strategies for people with uncontrolled diabetes

Study may lead to effective antimicrobial treatment strategies for people with uncontrolled diabetes

Case Western Reserve scientists may have uncovered a molecular mechanism that sets into motion dangerous infection in the feet and hands often occurring with uncontrolled diabetes. It appears that high blood sugar unleashes destructive molecules that interfere with the body's natural infection-control defenses. [More]
Inflammation from diets deficient in nutrients contribute to weight despite intake of macronutrients

Inflammation from diets deficient in nutrients contribute to weight despite intake of macronutrients

If you are watching what you eat, working out, and still not seeing improvements in your cholesterol, blood pressure, blood sugar, etc., here's some hope. A new report appearing in the August 2015 issue of The FASEB Journal suggests that inflammation induced by deficiencies in vitamins and minerals might be the culprit. [More]
Metformin drug has impact on blood fat levels

Metformin drug has impact on blood fat levels

Besides affecting the blood sugar levels, the substance Metformin, also has an impact on blood fat levels. This was elucidated by an interdisciplinary team of the German Center for Diabetes Research headed by Dr. Rui Wang-Sattler of the Helmholtz Zentrum München. Especially the harmful LDL cholesterol can be reduced. [More]
Diet high in refined carbohydrates may lead to depression risk in postmenopausal women

Diet high in refined carbohydrates may lead to depression risk in postmenopausal women

A diet high in refined carbohydrates may lead to an increased risk for new-onset depression in postmenopausal women, according to a study published in The American Journal of Clinical Nutrition. [More]
Researchers reveal how insulin reaches and acts in the brain to improve memory

Researchers reveal how insulin reaches and acts in the brain to improve memory

Researchers at the UW Medicine, Veteran's Administration Puget Sound and Saint Louis University have made a promising discovery that insulin delivered high up in the nasal cavity goes to affected areas of brain with lasting results in improving memory. [More]
TWi Biotechnology gets notice of patent allowance covering use of AC-201 drug in diabetes treatment

TWi Biotechnology gets notice of patent allowance covering use of AC-201 drug in diabetes treatment

TAIPEI, Aug. 3, 2015 /PRNewswire/ -- TWi Biotechnology, Inc., today announced that it has received Notices of Allowance for AC-201, TWi Biotechnology's lead drug candidate, from the European Patent Office and the Patent Office of the Russian Federation for patent applications numbered 11766702.2-1460 and 2012147449, respectively. [More]
Integrated treatment required for diabetes-eating disorder combination

Integrated treatment required for diabetes-eating disorder combination

As they reach their teens, many with type 1 diabetes discover that the disease provides a secret weapon for losing weight. By restricting or reducing the amount of insulin they inject, they can eat just about anything they want and control their weight. [More]
Bioenergetic analysis of pancreatic beta-cells shows impaired metabolic signature in type 2 diabetes patients

Bioenergetic analysis of pancreatic beta-cells shows impaired metabolic signature in type 2 diabetes patients

Impaired activation of mitochondrial energy metabolism in the presence of glucose has been demonstrated in pancreatic beta-cells from patients with type 2 diabetes. The cause of this dysfunction has been unknown. Publishing online in Endocrinology, Buck Institute assistant research professor Akos Gerencser, PhD, shows that in patients with type 2 diabetes the balance between supply and demand of the mitochondrial membrane potential (ΔψM) is altered causing a decrease in the signaling that turns on insulin secretion. [More]
Low blood level of 4 proteins can help diabetics protect against immune attack

Low blood level of 4 proteins can help diabetics protect against immune attack

Patients with type 1 diabetes have significantly lower blood levels of four proteins that help protect their tissue from attack by their immune system, scientists report. [More]
LixiLan-O Phase III clinical trial meets primary endpoint in patients with type 2 diabetes

LixiLan-O Phase III clinical trial meets primary endpoint in patients with type 2 diabetes

Sanofi announced today that the LixiLan-O Phase III clinical trial met its primary objective in patients with type 2 diabetes treated with metformin. The fixed-ratio combination of insulin glargine 100 units/mL and lixisenatide, a GLP-1 RA, demonstrated statistically superior reduction in HbA1c (average blood glucose over the previous three months) compared with lixisenatide and compared with insulin glargine 100 units/mL. [More]
Researchers explore impact of nutrients, probiotics before and during pregnancy on mothers and babies

Researchers explore impact of nutrients, probiotics before and during pregnancy on mothers and babies

Researchers in the United Kingdom (Southampton), Singapore and New Zealand (Auckland) from the EpiGen Global Research Consortium are to trial the use of a combination of nutrients and probiotics before and during pregnancy in a bid to improve the health of mothers and their babies. [More]
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