Bone Cancer News and Research RSS Feed - Bone Cancer News and Research

Bone cancer may be of two basic types 1. Primary bone cancer - cancer that begins in the bone, 2. Secondary bone cancer - cancer that begins elsewhere in the body (for example lungs, breast, liver etc.) that has spread to the bone. Primary bone cancer is a rare form of cancer - about 500 cases are diagnosed in the UK each year (only about one in every 500 cancers).
Histone mutation linked to fatal pediatric brain tumor

Histone mutation linked to fatal pediatric brain tumor

A single defect in a gene that codes for a histone — a "spool" that wraps idle DNA — is linked to pediatric cancers in a study published today in the journal Science. [More]
Study shows male cancer survivors less likely to have children

Study shows male cancer survivors less likely to have children

A study of all Norwegian men born between 1965 and 1985 shows that male cancer survivors are less likely to have children than those without a cancer diagnosis. [More]
DNA imprinting defect may affect children diagnosed with osteosarcoma

DNA imprinting defect may affect children diagnosed with osteosarcoma

Children diagnosed with osteosarcoma may be impacted by a DNA imprinting defect also found in parents, according to new research from the Masonic Cancer Center, University of Minnesota. DNA imprinting is a phenomenon in which just one of the two inherited genes is active while the other is present but inactive. [More]
Scientists discover that blocking RANKL protein stops osteosarcoma

Scientists discover that blocking RANKL protein stops osteosarcoma

Scientists at Princess Margaret Cancer Centre have discovered that blocking the master regulator of bone renewal stops osteosarcoma - the most common primary bone cancer in children and teens, and the malignant disease that was fatal for Canadian icon Terry Fox. [More]
New mathematical model forecasts metastatic breast cancer survival rates

New mathematical model forecasts metastatic breast cancer survival rates

USC researchers have developed a mathematical model to forecast metastatic breast cancer survival rates using techniques usually reserved for weather prediction, financial forecasting and surfing the Web. [More]
HEAL Project aims to regenerate human knees and limbs within 15 years

HEAL Project aims to regenerate human knees and limbs within 15 years

On Veteran's Day the University of Connecticut announced the launch of its new grand research challenge: regeneration of a human knee within 7 years, and an entire limb within 15 years. [More]
Agios announces data from dose-escalation phase 1 study of AG-120 in patients with IDH1 mutant positive advanced solid tumors

Agios announces data from dose-escalation phase 1 study of AG-120 in patients with IDH1 mutant positive advanced solid tumors

Agios Pharmaceuticals, Inc., a leader in the fields of cancer metabolism and rare genetic metabolic disorders, today announced the first data from the dose-escalation portion of the ongoing Phase 1 study evaluating single agent AG-120, a first-in-class, oral, selective, potent inhibitor of mutant isocitrate dehydrogenase-1 (IDH1), in advanced solid tumors. The data are being presented today at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics in Boston. AG-120 is being developed in collaboration with Celgene. [More]
Danish researchers face possible breakthrough in fight against cancer

Danish researchers face possible breakthrough in fight against cancer

The hunt for a vaccine against malaria in pregnant women has provided an unexpected side benefit for Danish researchers, namely what appears to be an effective weapon against cancer. The scientists behind the vaccine aim for tests on humans within four years. [More]
YK-4-279 compound works against some forms of leukemia: Study

YK-4-279 compound works against some forms of leukemia: Study

A compound discovered and developed by a team of Georgetown Lombardi Comprehensive Cancer Center researchers that halts cancer in animals with Ewing sarcoma and prostate cancer appears to work against some forms of leukemia, too. [More]
CHAM, AECC receive $1.3 million NCI grant to advance more effective bone cancer treatments for children

CHAM, AECC receive $1.3 million NCI grant to advance more effective bone cancer treatments for children

The Children's Hospital at Montefiore and the NCI-designated Albert Einstein Cancer Center today announced receipt of $1.3 million grant from the National Cancer Institute, part of the National Institutes of Health. [More]
MACC1 gene can help predict better treatment options for patients with Klatskin carcinoma

MACC1 gene can help predict better treatment options for patients with Klatskin carcinoma

Bile duct cancer is rare and is usually detected too late. Often only extensive liver surgery can help or, in rare cases, liver transplantation. But which patients will benefit from surgery and which will not, because their risk of cancer recurrence is too high? With the oncogene MACC1 as a biomarker, physicians for the first time have a tool to decide which treatment option is best for patients with Klatskin carcinoma, one type of bile duct cancer. [More]
Researchers show how realistic environments affect growth of cancer tumors in bones

Researchers show how realistic environments affect growth of cancer tumors in bones

Researchers at Rice University and University of Texas MD Anderson Cancer Center have developed a way to mimic the conditions under which cancer tumors grow in bones. [More]
LMU researchers reveal role of mutations in development of Ewing's sarcoma

LMU researchers reveal role of mutations in development of Ewing's sarcoma

Researchers from Ludwig-Maximilians-Universitaet in Munich have elucidated at the molecular level how an otherwise innocuous inherited mutation that is quite common in European populations interacts with a spontaneous somatic mutation to promote the development of Ewing's sarcoma. [More]
Alternative limb-lengthening technique makes recovery process less cumbersome

Alternative limb-lengthening technique makes recovery process less cumbersome

A highly specialized procedure that lengthens bones can prevent the need for amputations in selected patients who have suffered severe fractures. [More]
UofL conducts Phase I research study for children with relapsed tumors

UofL conducts Phase I research study for children with relapsed tumors

Zach feels "pretty good." Sam wants to be "done with shots!" And Tyler finds it helps to "just keep thinking that at least I'm getting out of school." They are normal boys who had normal lives until cancer came into the picture. All have faced the disease for two years or more, with surgeries, chemotherapy and radiation treatments. All were diagnosed with various malignant solid tumors, went into remission and then relapsed. [More]
Imaging technique could help in diagnosis of atherosclerosis in at-risk patients

Imaging technique could help in diagnosis of atherosclerosis in at-risk patients

Researchers at the University of Cambridge, in collaboration with the University of Edinburgh, have shown how a radioactive agent developed in the 1960s to detect bone cancer can be re-purposed to highlight the build-up of unstable calcium deposits in arteries, a process that can cause heart attack and stroke. [More]
New therapeutic alternative found for children suffering from Ewing's sarcoma

New therapeutic alternative found for children suffering from Ewing's sarcoma

A research consortium made up of the Virgen del Rocio hospital in Seville, Sant Joan de Deu and the Bellvitge Biomedical Research Institute in Barcelona, has found a new therapeutic alternative for children who suffer from a malignant pediatric tumor bone and soft tissue called Ewing's sarcoma. [More]
Study opens new area of discovery for different aspects of cell biology, biomedical research

Study opens new area of discovery for different aspects of cell biology, biomedical research

Every cell in the body uses phosphorylation, the process of adding a chemical tag to control a protein's function and fate, such as when it moves from one part of a cell to another or binds to other proteins. [More]
FDA clears ADXS-HPV plus epacadostat IND for HPV-associated cervical cancer Phase 2 study

FDA clears ADXS-HPV plus epacadostat IND for HPV-associated cervical cancer Phase 2 study

Advaxis, Inc., a clinical-stage biotechnology company developing cancer immunotherapies, today announced the clearance of the Investigational New Drug application by the United States Food and Drug Administration to conduct a Phase 2 study of ADXS-HPV (ADXS11-001) alone or in combination with Incyte Corporation's investigational oral indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor, epacadostat (INCB24360), for the treatment of Stage I-IIIb human papillomavirus (HPV)-associated cervical cancer. [More]
Stem cell disease model reveals how tumor suppressor may drive bone cancer

Stem cell disease model reveals how tumor suppressor may drive bone cancer

Using induced pluripotent stem cells (iPSCs), a team led by Mount Sinai researchers has gained new insight into genetic changes that may turn a well known anti-cancer signaling gene into a driver of risk for bone cancers, where the survival rate has not improved in 40 years despite treatment advances. [More]
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