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Celiac disease is an inherited autoimmune disorder where gluten has been identified as the environmental trigger of the disease. Gluten is an ingested protein found in wheat, barley and rye. Gluten is broken down into gliadin which can pass through the intestinal epithelial barrier during times of increased intestinal permeability. The ingestion of gluten causes an immune response which triggers an inflammatory reaction in the small intestine. This then causes damage to the villi in the small intestine and can lead to total villous atrophy in celiac disease. This results in varying symptoms such as fatigue, skin rash, anemia, fertility issues, joint pain, weight loss, pale sores inside the mouth, tooth discoloration or loss of enamel, depression, chronic diarrhea or constipation, gas and abdominal pain. The immunology and nutritional abnormalities in celiac disease can potentially result in long- term complications such as osteoporosis, refractory sprue, small intestinal cancer, and lymphoma.

Celiac disease is a growing public health concern, affecting approximately 3 million people in the United States and over 6.5 million people worldwide. The only current management of celiac disease is complete elimination of gluten from the diet, which can be very difficult to implement in practice. Additionally, the response to the gluten-free diet is poor in up to 30% of patients, and dietary nonadherence is the chief cause of persistent or recurrent symptoms.
Latest popular diets have nutrient gaps

Latest popular diets have nutrient gaps

Paleo, high-protein, low-carb, gluten-free, vegetarian and vegan eating lifestyles have all exploded in popularity in the last few years. Whether people adopt these diets in order to lose weight or maintain overall wellness, consumers that follow them may be missing out on some essential nutrients. In the April issue of Food Technology Magazine, Linda Mila Ohr writes about the nutrient gaps in these various diets and how consumers can make sure they get the nutrients they need. [More]
Series of routine tests may not be beneficial to patients with age-related disorder

Series of routine tests may not be beneficial to patients with age-related disorder

A series of tests physicians routinely order to help diagnose and follow their patients with an elevated antibody level that is a marker for cancer risk, often do not benefit the patient but do increase health care costs, pathologists report. [More]
Study points to possible new genetic risk factor for celiac disease

Study points to possible new genetic risk factor for celiac disease

Researchers have identified a common variant in a non-coding RNA that may contribute to the intestinal inflammation that occurs in people with celiac disease. The findings point to a possible new risk factor for developing celiac disease in people with celiac disease risk genes. [More]
Simple method to determine prevalence of celiac disease in children aged 2-4

Simple method to determine prevalence of celiac disease in children aged 2-4

Researchers from the University of Granada have developed a new, simple and non invasive method which allows to determine whether a child aged 2-4 suffers from celiac disease or not without the necessity of a blood extraction. [More]
BioLineRx announces year end 2015 financial results, provides operational update

BioLineRx announces year end 2015 financial results, provides operational update

BioLineRx Ltd., a clinical-stage biopharmaceutical company dedicated to identifying, in-licensing and developing promising therapeutic candidates, today reported its financial results for the year ended December 31, 2015. [More]
Loyola offers multidisciplinary digestive health program

Loyola offers multidisciplinary digestive health program

Loyola University Health System now offers a multidisciplinary digestive health program to treat digestive tract and related medical conditions. Bipan Chand, MD, FACS, FASGE, FASMBS, and Neil Gupta, MD, MPH, are co-directors of the new program. [More]
BioLineRx's BL-7010 confirmed as Class IIb medical device in European Union

BioLineRx's BL-7010 confirmed as Class IIb medical device in European Union

BioLineRx Ltd., a clinical-stage biopharmaceutical company dedicated to identifying, in-licensing and developing promising therapeutic candidates, announced today that it has received confirmation from the European Notified Body regarding the classification of BL-7010, a novel polymer for the treatment of celiac disease, as a Class IIb medical device in the European Union. [More]
Age of gluten introduction does not reduce risk of celiac disease in at-risk infants

Age of gluten introduction does not reduce risk of celiac disease in at-risk infants

Based on new evidence, the age of introduction of gluten into the infant diet -- or the practice of introducing gluten during breast-feeding -- does not reduce the risk of celiac disease in infants at risk, according to a Position Paper of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition. [More]
Processed foods may increase likelihood of developing autoimmune diseases

Processed foods may increase likelihood of developing autoimmune diseases

In today's hustle and bustle world, processed foods are commonplace time-savers. But that convenience factor may come with a bigger price tag than previously known, says an international team of researchers. [More]
New biobank initiative may help unlock some of the mysteries linked to Down syndrome

New biobank initiative may help unlock some of the mysteries linked to Down syndrome

Nationwide Children's Hospital and research advocacy group DownSyndrome Achieves have joined forces to create the first biobank in the country dedicated to collecting and managing blood samples from people with Down syndrome. [More]
New report reviews current WIC food packages

New report reviews current WIC food packages

Women and children who participate in the WIC program have low or inadequate intakes of several key nutrients that could be addressed with changes to the program's food packages, says a new report from the National Academies of Sciences, Engineering, and Medicine. [More]
Intake of gluten increases risk of celiac disease in children

Intake of gluten increases risk of celiac disease in children

Intake of gluten up until two years of age increases risk of celiac disease at least two-fold in children with genetic risk factors for this disease, according a study published in Clinical Gastroenterology and Hepatology the official clinical practice journal of the American Gastroenterological Association. [More]
Environmental and lifestyle factors contribute to development of celiac disease

Environmental and lifestyle factors contribute to development of celiac disease

Celiac disease incidence has increased among Swedish children between 2 to 15 years. The significant escalation in celiac disease can be associated with planned caesarean sections, urinary tract infections during pregnancy, season of birth and being born in south Sweden. [More]
Saint Louis University ophthalmologist offers tips to manage night vision issues

Saint Louis University ophthalmologist offers tips to manage night vision issues

Owls and cats are at an advantage as the days get darker, but humans may notice their vision takes a hit during their evening commute home as daylight hours shrink. [More]
Celiac patients at no increased risk for dementia, study finds

Celiac patients at no increased risk for dementia, study finds

A new and comprehensive study by investigators at the Celiac Disease Center at Columbia University Medical Center has found that celiac patients are at no increased risk for dementia before or after their diagnosis of celiac disease. [More]
Commonwealth Lab expands access to new IBS test with national agreement with Quest

Commonwealth Lab expands access to new IBS test with national agreement with Quest

Commonwealth Laboratories, LLC ("Commonwealth") announced today that it has formed an agreement with Quest Diagnostics ("Quest") that will expand the availability of IBSchekā„¢, a new laboratory developed blood test designed to help physicians quickly and reliably diagnose Irritable Bowel Syndrome (IBS). [More]
Scientists calculate precise measurements of heritability in nine pediatric-onset autoimmune diseases

Scientists calculate precise measurements of heritability in nine pediatric-onset autoimmune diseases

Scientists have calculated more precise measurements of heritability--the influence of underlying genes--in nine autoimmune diseases that begin in childhood. The research may strengthen researchers' abilities to better predict a child's risk for associated autoimmune diseases. [More]
Research finding could lead to new treatments for celiac disease

Research finding could lead to new treatments for celiac disease

A team of researchers has discovered that bacteria found in the gut may contribute to the body's response to gluten, an important finding that could lead to new treatments for celiac disease. [More]
Gut microbiome can play significant role in the body's response to gluten

Gut microbiome can play significant role in the body's response to gluten

Investigators interested in celiac disease, a chronic gastrointestinal disorder caused by an immunologic response to the ingestion of gluten, have wondered why only 2% to 5% of genetically susceptible individuals develop the disease. [More]

AFM Images of microvilli on live cells taken for the first time

In a just released article in the Journal of Molecular Recognition, Dr. Hermann Schillers et al. report the first visualization of individual microvilli on living cells with atomic force microscopy. [More]
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