Celiac Disease News and Research

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Celiac disease is an inherited autoimmune disorder where gluten has been identified as the environmental trigger of the disease. Gluten is an ingested protein found in wheat, barley and rye. Gluten is broken down into gliadin which can pass through the intestinal epithelial barrier during times of increased intestinal permeability. The ingestion of gluten causes an immune response which triggers an inflammatory reaction in the small intestine. This then causes damage to the villi in the small intestine and can lead to total villous atrophy in celiac disease. This results in varying symptoms such as fatigue, skin rash, anemia, fertility issues, joint pain, weight loss, pale sores inside the mouth, tooth discoloration or loss of enamel, depression, chronic diarrhea or constipation, gas and abdominal pain. The immunology and nutritional abnormalities in celiac disease can potentially result in long- term complications such as osteoporosis, refractory sprue, small intestinal cancer, and lymphoma.

Celiac disease is a growing public health concern, affecting approximately 3 million people in the United States and over 6.5 million people worldwide. The only current management of celiac disease is complete elimination of gluten from the diet, which can be very difficult to implement in practice. Additionally, the response to the gluten-free diet is poor in up to 30% of patients, and dietary nonadherence is the chief cause of persistent or recurrent symptoms.
MGH researchers provide direct link between ‘leaky gut’ and chronic inflammatory disease

MGH researchers provide direct link between ‘leaky gut’ and chronic inflammatory disease

Opportunities and risks of direct-to-consumer genetic health risk tests

Opportunities and risks of direct-to-consumer genetic health risk tests

Viral trigger may underlie development of celiac disease

Viral trigger may underlie development of celiac disease

UC Riverside professor receives grant to explore therapeutic target for treating IBD patients

UC Riverside professor receives grant to explore therapeutic target for treating IBD patients

Infection with reovirus could be key initiating event for developing celiac disease, study suggests

Infection with reovirus could be key initiating event for developing celiac disease, study suggests

FDA authorizes marketing of first direct-to-consumer GHR tests for certain diseases

FDA authorizes marketing of first direct-to-consumer GHR tests for certain diseases

Physicians recommend whole food, plant-based eating patterns for optimal heart health

Physicians recommend whole food, plant-based eating patterns for optimal heart health

Discovery of 'molecular switch' could lead to effective new treatments for auto-immune diseases

Discovery of 'molecular switch' could lead to effective new treatments for auto-immune diseases

Gluten-free diets linked to increased risk for arsenic and mercury exposure

Gluten-free diets linked to increased risk for arsenic and mercury exposure

Type 1 diabetes patients show distinct signs of gut inflammation, study reveals

Type 1 diabetes patients show distinct signs of gut inflammation, study reveals

Factors that impact fertility in men

Factors that impact fertility in men

Study finds 1 in 5 pediatric celiac disease patients on gluten-free diet sustain persistent intestinal damage

Study finds 1 in 5 pediatric celiac disease patients on gluten-free diet sustain persistent intestinal damage

Early life history and genetics may play crucial role in shaping gut microbiome

Early life history and genetics may play crucial role in shaping gut microbiome

Identifying foods that trigger IBS: an interview with Dr Bill Chey

Identifying foods that trigger IBS: an interview with Dr Bill Chey

Nearly 20% of children with celiac disease have persistent enteropathy despite gluten-free diet

Nearly 20% of children with celiac disease have persistent enteropathy despite gluten-free diet

Low fat and low carbohydrate diets may prevent migraines

Low fat and low carbohydrate diets may prevent migraines

Amount of gluten triggers genetic risk of celiac disease, research shows

Amount of gluten triggers genetic risk of celiac disease, research shows

Study suggests interactions between distant DNA regions may impact disease gene levels

Study suggests interactions between distant DNA regions may impact disease gene levels

Enzyme from oral bacteria could be potential therapy for celiac disease

Enzyme from oral bacteria could be potential therapy for celiac disease

Type of bacteria in the gut may increase or decrease risk of developing celiac disease

Type of bacteria in the gut may increase or decrease risk of developing celiac disease