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Researchers reveal novel mechanism by which viral protein VII suppresses immune alarm signals

Researchers reveal novel mechanism by which viral protein VII suppresses immune alarm signals

Viruses must avoid a host's immune system to establish successful infections—and scientists have discovered another tool that viruses use to frustrate host defenses. [More]
KIT researchers develop 3D prostate model based on cryogels

KIT researchers develop 3D prostate model based on cryogels

A team of researchers led by Dr. Friederike J. Gruhl and Professor Andrew C. B. Cato at Karlsruhe Institute of Technology are developing a three-dimensional model for prostate cancer research based on cryogels. [More]
Novel method uses lasers to carve paths inside biocompatible gels

Novel method uses lasers to carve paths inside biocompatible gels

Future medicine is bound to include extensive tissue-engineering technologies such as organs-on-chips and organoids - miniature organs grown from stem cells. But all this is predicated on a simple yet challenging task: controlling cellular behavior in three dimensions. [More]
Researchers find new method to replicate one of earliest changes in Alzheimer’s disease

Researchers find new method to replicate one of earliest changes in Alzheimer’s disease

Researchers at the Babraham Institute have found a way to replicate one of the earliest changes in Alzheimer's disease in a dish. This means that it should now be possible to find out a lot more about why it happens - and how to stop it. The new findings are published in the journal Molecular Neurodegeneration and supported by the charity Alzheimer's Research UK. [More]
New study may help unveil structure and behavior of neurotoxic oligomers in Alzheimer's disease

New study may help unveil structure and behavior of neurotoxic oligomers in Alzheimer's disease

Much of the research on Alzheimer's disease has focused on the amyloid beta protein, which clumps together into sticky fibrils that form deposits in the brains of people with the disease. [More]
Study captures interactions of HIV-infected immune cells in living animal

Study captures interactions of HIV-infected immune cells in living animal

By watching brightly glowing HIV-infected immune cells move within mice, researchers at the Icahn School of Medicine at Mount Sinai have shown how infected immune cells latch onto an uninfected sister cell to directly transmit newly minted viral particles. [More]
New mathematical model helps examine metabolism of breast epithelium

New mathematical model helps examine metabolism of breast epithelium

Researchers have built a model to investigate the metastasis of cancer by examining the metabolism of breast epithelial cells and look at the role of signaling. This research, published in PLOS Computational Biology, may contribute to the development of cell specific anti-cancer interventions. [More]
Study establishes copper’s role in fat metabolism

Study establishes copper’s role in fat metabolism

A new study is further burnishing copper's reputation as an essential nutrient for human physiology. A research team led by a scientist at the Department of Energy's Lawrence Berkeley National Laboratory and at the University of California, Berkeley, has found that copper plays a key role in metabolizing fat. [More]
New research pinpoints specific lncRNA that regulates neural development

New research pinpoints specific lncRNA that regulates neural development

Compared to other mammals, humans have the largest cerebral cortex. A sheet of brain cells that folds in on itself multiple times in order to fit inside the skull, the cortex is the seat of higher functions. It is what enables us to process everything we see and hear and think. [More]
Lower quantities of CD74 protein in placentas of preeclamptic women can impact fetal development

Lower quantities of CD74 protein in placentas of preeclamptic women can impact fetal development

Preeclampsia is one of the most common complications to occur during pregnancy, yet its causes are still unknown. A new study involving patients, cell cultures and animal experiments has now shown that those affected by the disease have lower quantities of the placenta's immune protein CD74, and that certain inflammatory factors are higher. These factors disrupt the formation of the placenta and leave the fetus undernourished. [More]
Buck researchers identify new, potential drug targets for sporadic PD

Buck researchers identify new, potential drug targets for sporadic PD

Research at the Buck Institute shows the same mechanisms that lead to neuronal cell death in mice genetically fated to develop Parkinson's disease (PD) are involved in the much more common sporadic form of the age-related, neurodegenerative disorder that robs people of the ability to move normally. [More]
Denosumab drug that inhibits RANKL gene can prevent genetic breast cancer

Denosumab drug that inhibits RANKL gene can prevent genetic breast cancer

An international team led by researchers at the Austrian Institute of Molecular Biotechnology in Vienna and the University of Maryland School of Medicine in Baltimore discovered that genetically determined breast cancer can be largely prevented by blocking a bone gene. An already approved drug could be quickly available and would then be the first breast cancer prevention drug. [More]
Researchers identify potential therapeutic target against oncogenic viral infection

Researchers identify potential therapeutic target against oncogenic viral infection

A benign virus normally found in the skin can lead to a type of rare, lethal skin cancer. Specifically, infection by the Merkel cell polyomavirus can lead to Merkel cell carcinoma in immune-compromised individuals. [More]
Scientists discover how Zika virus replicates in the placenta

Scientists discover how Zika virus replicates in the placenta

Zika virus can infect and replicate in immune cells from the placenta, without killing them, scientists have discovered. The finding may explain how the virus can pass through the placenta of a pregnant woman, on its way to infect developing brain cells in her fetus. [More]
Metabolic characteristics of CRPC may open new avenues for treatment

Metabolic characteristics of CRPC may open new avenues for treatment

Advanced prostate cancer is usually treated by removing androgen, the male hormone that helps it grow. Although initially effective, this treatment often leads to the tumor becoming castration resistant- a lethal condition. [More]
High quality exosome research products

High quality exosome research products

AMSBIO has introduced a wide selection of new high quality products for exosome research. Formulated to be quick, affordable and easy to use, AMSBIO's new expanded suite of quantification kits, isolation tools, standards, DNA & RNA extraction kits, antibodies and cell culture reagents will facilitate your understanding of exosomes using a wide variety of samples. [More]
WPI receives patent for novel method of reprogramming human skin cells

WPI receives patent for novel method of reprogramming human skin cells

Cell therapies for a range of serious conditions, including heart attacks, diabetes, and traumatic injuries, will be accelerated by research at Worcester Polytechnic Institute that yielded a newly patented method of converting human skin cells into engines of wound healing and tissue regeneration. [More]
Real-time intracellular oxygen assay

Real-time intracellular oxygen assay

AMSBIO has introduced MitoXpress® Intra, a novel intracellular oxygen assay based on a 96 or 384-well fluorescence plate reader-based approach that facilitates the real-time assessment of transient changes in cell respiration, oxygen gradients and physiological responses across a range of cell models. [More]
New bio-mimicry method allows scientists to track cells in vivo using MRI during preclinical, clinical trials

New bio-mimicry method allows scientists to track cells in vivo using MRI during preclinical, clinical trials

Researchers led by Carnegie Mellon University Professor of Biological Sciences Chien Ho have developed a new method for preparing mesenchymal stem cells (MSCs) that not only leads to the production of more native stem cells, but also labels them with a FDA approved iron-oxide nanoparticle (Ferumoxytol). [More]
Scientists prove effectiveness of gene editing system in eliminating HIV from DNA of CD4+ T-cells

Scientists prove effectiveness of gene editing system in eliminating HIV from DNA of CD4+ T-cells

In 2014, a team of researchers in the Lewis Katz School of Medicine at Temple University became the first to successfully eliminate the HIV-1 virus from cultured human cells. [More]
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