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Molecules team up to maintain healthy level of fat in liver, study finds

Molecules team up to maintain healthy level of fat in liver, study finds

As obesity rates rise in the United States, so does the incidence of liver diseases. [More]
Weight loss condition provides clues to why cancer immunotherapy may fail in many patients

Weight loss condition provides clues to why cancer immunotherapy may fail in many patients

A weight loss condition that affects patients with cancer has provided clues as to why cancer immunotherapy - a new approach to treating cancer by boosting a patient's immune system -- may fail in a substantial number of patients. [More]
New research explains how tumors may impair ability of the liver to respond to caloric deprivation

New research explains how tumors may impair ability of the liver to respond to caloric deprivation

One of the worst cruelties of lethal cancer is the phenomenon called wasting, or in medical terms, cachexia (pronounced ka-CHEX-ia), in which a patient seems literally to diminish in bodily terms as the cancer ravages one or more internal organs. [More]
Researchers identify possible trigger of chronic inflammation in people with diabetes

Researchers identify possible trigger of chronic inflammation in people with diabetes

Inflammation is one of the main reasons why people with diabetes experience heart attacks, strokes, kidney problems and other, related complications. Now, in a surprise finding, researchers at Washington University School of Medicine in St. Louis have identified a possible trigger of chronic inflammation. [More]
Study shows metabolite concentration can be controlled in bioreactors using OPC enabled BioProfile FLEX analyser

Study shows metabolite concentration can be controlled in bioreactors using OPC enabled BioProfile FLEX analyser

Current initiatives within the biopharmaceutical industry to adopt PAT (Process Analytical Technology) approaches in manufacturing, include activities in early process development. [More]
Turning off TAZ protein in liver cells reverses fibrosis in mice

Turning off TAZ protein in liver cells reverses fibrosis in mice

Scientists at Columbia University Medical Center have identified a factor in liver cells that is responsible for turning a relatively benign liver condition, present in 30 percent of U.S. adults, into a serious disease that can lead to liver failure. [More]
Natural compound slows typical signs of aging in mice

Natural compound slows typical signs of aging in mice

Much of human health hinges on how well the body manufactures and uses energy. For reasons that remain unclear, cells' ability to produce energy declines with age, prompting scientists to suspect that the steady loss of efficiency in the body's energy supply chain is a key driver of the aging process. [More]
Neonate girls present greater antioxidant defense, less oxidative stress than boys

Neonate girls present greater antioxidant defense, less oxidative stress than boys

A study carried out by researchers from the University of Granada in collaboration with San Cecilio Clinic Hospital has scientifically proved that neonate girls present a greater antioxidant defense and less oxidative stress on their cell membranes than boys, in addition to higher antioxidant enzymatic activity. [More]
Research shows metabolism of macrophages can be attuned to prevent spread of cancer

Research shows metabolism of macrophages can be attuned to prevent spread of cancer

Scientists at VIB and KU Leuven have discovered a crucial factor in the spread of cancer. A team led by professor Massimiliano Mazzone has demonstrated that the metabolism of macrophages, a particular type of white blood cell, can be attuned to prevent the spread of cancer. [More]
Substance NAD+ can extend life and postpone onset of aging processes

Substance NAD+ can extend life and postpone onset of aging processes

The coenzyme NAD+ plays a main role in aging processes. In mice and roundworm adding the substance can both extend life and postpone the onset of aging processes. [More]
Scientists manage to produce first molecular map of genes in the pancreas

Scientists manage to produce first molecular map of genes in the pancreas

Researchers at Karolinska Institutet have managed to produce the first molecular map of the genes that are active in the various cells of the human pancreas. [More]
HMS scientists reveal how certain tumors develop taste for fat

HMS scientists reveal how certain tumors develop taste for fat

Cancers are such notorious sugar addicts that PET scans searching for the disease light up when they detect sugar-gobbling tumor cells. [More]
Research findings of protein may form foundation for new approach to antibiotics

Research findings of protein may form foundation for new approach to antibiotics

Researchers have made the first-ever detailed, atomic-level images of a peroxiredoxin, which has revealed a peculiar characteristic of this protein and might form the foundation for a new approach to antibiotics. [More]
UCSF researchers identify new strategy to cultivate beneficial energy-burning fat

UCSF researchers identify new strategy to cultivate beneficial energy-burning fat

UC San Francisco researchers studying beige fat — a calorie-burning tissue that can help to ward off obesity and diabetes — have discovered a new strategy to cultivate this beneficial blubber. [More]
New chemical compound could potentially be used to treat Ebola virus infection

New chemical compound could potentially be used to treat Ebola virus infection

Scientists have found Ebola's Achilles' heel: a new kind of chemical compound can block the protein Ebola uses to break out of cells and infect new cells. [More]
Glia cells may play role in regulating sugar intake into the brain, experts report

Glia cells may play role in regulating sugar intake into the brain, experts report

Researchers at Technical University of Munich discovered that our brain actively takes sugar from the blood. Prior to this, researchers around the world had assumed that this was a purely passive process. [More]
Penn study sheds light on role of essential compound in maintaining optimal muscle function

Penn study sheds light on role of essential compound in maintaining optimal muscle function

Maintaining proper levels of an essential helper molecule is crucial for optimal muscle function, according to a study led by Joseph Baur, PhD, an assistant professor of Physiology in the Perelman School of Medicine at the University of Pennsylvania. [More]
Researchers uncover how GWAS-implicated gene affects HDL-cholesterol levels

Researchers uncover how GWAS-implicated gene affects HDL-cholesterol levels

Researchers have uncovered how genes identified from genome-wide association studies (GWAS) affect high-density lipoprotein cholesterol (HDL-C), a biomarker of cardiovascular disease, after comparing several animal models with human patient data. [More]
Research finding opens door to potential clinical approaches that may boost body's ability to battle cancer

Research finding opens door to potential clinical approaches that may boost body's ability to battle cancer

The microenvironment that supports a cancerous tumor also starves the immune cells that the body sends in to destroy the cancer, University of Pittsburgh Cancer Institute scientists revealed in a discovery that holds the potential to significantly boost the performance of breakthrough immunotherapy drugs. [More]
Single drink of nutritional ketone can alter metabolism to improve performance of cyclists

Single drink of nutritional ketone can alter metabolism to improve performance of cyclists

A drink developed for soldiers to generate energy from ketones rather than carbs or fat allowed highly trained cyclists to add up to 400 meters of distance to their workouts, a UK-led study reports July 27 in Cell Metabolism. [More]
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