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UT Southwestern researchers reveal how CDK4/6-inhibitors alter pancreatic cancer cell metabolism

UT Southwestern researchers reveal how CDK4/6-inhibitors alter pancreatic cancer cell metabolism

UT Southwestern Medical Center researchers have found that cancer drugs known as CDK4/6-inhibitors alter the metabolism of pancreatic cancer cells, revealing a biologic vulnerability that could be exploited for therapeutic gain. [More]
Estrogen helps women fight flu virus better than men

Estrogen helps women fight flu virus better than men

Estrogen dramatically reduced the amount of flu virus that replicated in infected cells from women but not from men, a new study by researchers at the Johns Hopkins Bloomberg School of Public Health shows. [More]
New discovery may help researchers tackle mitochondrial diseases and age-related diseases

New discovery may help researchers tackle mitochondrial diseases and age-related diseases

Buck Institute faculty Judith Campisi, PhD, says age researchers need to stop thinking of cellular senescence, now accepted as an important driver of aging, as a single phenotype that stems from genotoxic stress. Research from her lab reveals that cellular senescence, a process whereby cells permanently lose the ability to divide, is also induced by signaling from dysfunctional mitochondria - and that the arrested cells secrete a distinctly different "stew" of biologically active factors in a process unrelated to the damaging free radicals that are created in mitochondria as part of oxygen metabolism. [More]
Oxygen sensor PHD1 identified as potential target for treatment of ischemic stroke

Oxygen sensor PHD1 identified as potential target for treatment of ischemic stroke

Scientists at VIB and KU Leuven have identified the oxygen sensor PHD1 as a potential target for the treatment of brain infarction (ischemic stroke). Despite (minor) improvements in stroke treatment, stroke remains the fourth leading cause of death and the most common reason of severe disability. [More]
Eliminating the 'bad seeds' of liver cancer

Eliminating the 'bad seeds' of liver cancer

Researchers have found the 'bad seeds' of liver cancer and believe they could one day reprogram them to remain responsive to cancer treatment, a new study has found. [More]
Researchers identify liver-derived hormone that regulates sugar intake

Researchers identify liver-derived hormone that regulates sugar intake

We all love our sugar, especially during the holidays. Cookies, cake, and candy are simply irresistible. While sugar cravings are common, the physiological mechanisms that trigger our "sweet tooth" are not well defined. [More]
New mathematical models shed light on complex interactions of stem cell function in neural tissue

New mathematical models shed light on complex interactions of stem cell function in neural tissue

New research has shed light on the complex interactions of stem cell function and molecular diffusion in neural tissue, which may explain many phenomena from stem cell differentiation to the formation of the cortex of the brain. While researching new methods of reconstructing 3D neural tissue and neural pathways in the brain and spinal cord, Dr. Richard McMurtrey devised new mathematical approaches for understanding the concentration of nutrients within the 3D tissue constructs and how this could affect tissue growth. [More]
Liver protein aids in accelerating growth of insulin-producing pancreatic 'beta' cells

Liver protein aids in accelerating growth of insulin-producing pancreatic 'beta' cells

More than a quarter of the 30 million people with diabetes in the United States depend on daily injections of insulin to maintain their blood glucose levels in a healthy range. Scientists are investigating many techniques to help treat or potentially even cure many of these patients by increasing the body's own insulin-producing pancreatic "beta" cells. [More]
Experimental drugs that modify cell metabolism also halt tumor growth

Experimental drugs that modify cell metabolism also halt tumor growth

Experimental drugs that alter cell metabolism also halted tumor growth and extended survival in mice with cancers linked to changes in the same gene, according to a new study led by researchers at NYU Langone Medical Center, its Laura and Isaac Perlmutter Cancer Center and Massachusetts General Hospital. [More]
Our appetite is dictated by gut bacteria

Our appetite is dictated by gut bacteria

Bacteria in our stomachs might be deciding when we’ve eaten enough and switch off appetite, according to new research. [More]
Seven new nCounter PanCancer profiles launched to deeply probe cancer biology

Seven new nCounter PanCancer profiles launched to deeply probe cancer biology

NanoString Technologies, Inc.a provider of life science tools for translational research and molecular diagnostic products, today announced the expansion of its 3D Biology™ portfolio with the commercial launch of the nCounter® PanCancer Profiles, seven new gene expression panels each designed to interrogate a focused area of cancer biology including immuno-oncology. [More]
Gut bacteria may increase risk of metabolic syndrome

Gut bacteria may increase risk of metabolic syndrome

An excess of bacteria in the gut can change the way the liver processes fat and could lead to the development of metabolic syndrome, according to health researchers. [More]
Researchers identify molecular switch that can convert unhealthy white fat into energy-burning brown fat

Researchers identify molecular switch that can convert unhealthy white fat into energy-burning brown fat

A research team led by UC San Francisco scientists has identified a molecular switch capable of converting unhealthy white fat into healthy, energy-burning brown fat in mice. Drugs that flip this switch rapidly reduced obesity and diabetes risk factors in mice fed a high fat diet. [More]
Biological sensor protein could help combat diabetes, obesity

Biological sensor protein could help combat diabetes, obesity

In the study, researchers showed a protein called NLRP1 is switched on when increased dietary energy (food) intake triggers the cell to become 'unstable'. [More]
Scientists find new way to inhibit growth of lung cancer cells

Scientists find new way to inhibit growth of lung cancer cells

Scientists have identified a new way to stop the growth of lung cancer cells, by blocking their ability to use alternative sources of nutrition. The discovery was made possible by identifying the metabolic programs used by cancer cells to fuel their growth. [More]
Study identifies four distinct types of bowel cancer

Study identifies four distinct types of bowel cancer

Bowel cancer can be divided up into four distinct diseases, each with its own set of biological characteristics, a major new study reports. [More]
Researchers find protein that plays crucial role in development of allergic airway inflammation

Researchers find protein that plays crucial role in development of allergic airway inflammation

Allergies are becoming more commonplace, particularly in industrialised coun-tries. In addition to hay fever, allergic asthma is currently considered to be one of the most widespread allergies. UFZ researchers and their colleagues from the University of Leipzig have recently been successful in finding a protein that plays a critical role in the development of allergic airway inflammation. [More]
Leading cancer researchers address eight 'big questions'

Leading cancer researchers address eight 'big questions'

Leading cancer researchers address eight of the "big questions" facing the field as part of the inaugural issue of Trends in Cancer, published by Cell Press. [More]
Cancer-causing gene disrupts internal rhythm, metabolic pathways in cancer cells

Cancer-causing gene disrupts internal rhythm, metabolic pathways in cancer cells

Myc is a cancer-causing gene responsible for disrupting the normal 24-hour internal rhythm and metabolic pathways in cancer cells, found a team led by researchers from the Perelman School of Medicine at the University of Pennsylvania. Postdoctoral fellow Brian Altman, PhD, and doctoral student Annie Hsieh, MD, both from the lab of senior author Chi Van Dang, MD, PhD, director Abramson Cancer Center, study body clock proteins associated with cancer cells. [More]
New research enables ‘tailored’ diet advice based on personal gut microbiome

New research enables ‘tailored’ diet advice based on personal gut microbiome

New research enables "tailored" diet advice - based on our personal gut microbiome - for persons who want to lose weight and reduce the risk of disease. [More]
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