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Targeting enzyme responsible for glucose metabolism halts tumor growth, say researchers

Targeting enzyme responsible for glucose metabolism halts tumor growth, say researchers

Cancer cells generate energy differently than normal cells, a characteristic that helps them to survive and metastasize. A major goal in the field of cancer metabolism is to find ways to overcome this survival advantage. [More]
Study: Obesity causes changes in colon that may lead to colorectal cancer

Study: Obesity causes changes in colon that may lead to colorectal cancer

Obesity, rather than diet, causes changes in the colon that may lead to colorectal cancer, according to a study in mice by the National Institutes of Health. The finding bolsters the recommendation that calorie control and frequent exercise are not only key to a healthy lifestyle, but a strategy to lower the risk for colon cancer, the second leading cause of cancer-related death in the United States. [More]
Insulin-secreting beta cells of pancreas have capacity to regenerate, say scientists

Insulin-secreting beta cells of pancreas have capacity to regenerate, say scientists

Vanderbilt University scientists have found evidence that the insulin-secreting beta cells of the pancreas, which are either killed or become dysfunctional in the two main forms of diabetes, have the capacity to regenerate. [More]
Researcher discover new chemical class that attacks two key cancer cell building block targets

Researcher discover new chemical class that attacks two key cancer cell building block targets

Imagine cutting down the growth of cancer cells at their earliest stages to halt tumor growth. Research conducted by leading cancer metabolism researchers at Stony Brook University, Paul M. Bingham, PhD, and Zuzana Zachar, PhD, is showing promise in this approach with their clinical investigation of a new class of compounds that disrupt cancer cell mitochondrial metabolism. [More]
Researchers examine association between diabetes and obesity

Researchers examine association between diabetes and obesity

It's by now well established that obesity is a major risk factor for diabetes. But what exactly is it about extra body fat that leads to insulin resistance and blood glucose elevation, the hallmarks of diabetes? [More]
Research shows depletion of cholesteryl ester impairs prostate cancer aggressiveness

Research shows depletion of cholesteryl ester impairs prostate cancer aggressiveness

Researchers have discovered a link between prostate cancer aggressiveness and the accumulation of a compound produced when cholesterol is metabolized in cells, findings that could bring new diagnostic and treatment methods. [More]
Researchers unravel function of proteins involved in cell metabolism

Researchers unravel function of proteins involved in cell metabolism

UCPs or uncoupling proteins are present in mitochondria, the powerhouse of each cell in the body. The functions of most of the five known UCPs remain mysterious (UCP2-UCP5), whereby only the distinct function for UCP1 has thus far been discovered. [More]
Eating high-protein diet in middle age is as deadly as smoking

Eating high-protein diet in middle age is as deadly as smoking

That chicken wing you're eating could be as deadly as a cigarette. In a new study that tracked a large sample of adults for nearly two decades, researchers have found that eating a diet rich in animal proteins during middle age makes you four times more likely to die of cancer than someone with a low-protein diet - a mortality risk factor comparable to smoking. [More]
Epidemiological studies demonstrate that diseases of central nervous system protect against cancer

Epidemiological studies demonstrate that diseases of central nervous system protect against cancer

Epidemiological studies demonstrate that diseases of the central nervous system such as Alzheimer, Parkinson and schizophrenia protect against cancer. The most remarkable example is Alzheimer's disease, which can reduce the risk of suffering from cancer by up to 50%. [More]
Sleep duration impacts on genetic risk of depressive symptoms

Sleep duration impacts on genetic risk of depressive symptoms

Both long and short sleep durations are associated with an increased heritability of depression, study findings show. [More]
Valproic acid metabolism and obesity: an interview with Dr. Namandjé Bumpus, Johns Hopkins Medicine

Valproic acid metabolism and obesity: an interview with Dr. Namandjé Bumpus, Johns Hopkins Medicine

Valproic acid is one of the most widely prescribed drugs for the treatment of epilepsy. It has also been shown to be effective for the treatment of mood disorders and migraine headaches. [More]

New effective method of treatment against increased cholesterol

Cardiovascular diseases are the number one cause of death globally due to e.g. arteriosclerosis. The cause is increased cholesterol. There is therefore a considerable need for an effective method of treatment against increased cholesterol. Now, Danish researchers have made a discovery that may change the picture of how it must be treated. [More]

Findings explain molecular mechanisms underlying microvascular disease in diabetes patients

Patients with diabetes are at increased risk of microvascular complications, which develop when the body's small blood vessels become diseased. One of the most common problems results when wounds fail to heal properly, which can lead to ulcers, chronic infections, and in the most serious cases, limb amputations. [More]

Scientists believe that new links between brain cells help encode new memories and skills

In adults, some brain regions retain a "childlike" ability to establish new connections, potentially contributing to our ability to learn new skills and form new memories as we age, according to new research from Washington University School of Medicine in St. Louis and the Allen Institute for Brain Science in Seattle. [More]

AP-1 proteins modulate fat accumulation in liver, say researchers

Excessive alcohol consumption, as well as obesity leads to the accumulation of fat in the liver, a disease termed fatty liver disease (FLD) or steatosis. FLD is one of the most prevalent diseases in Western societies and affects about 30% of the adult population. Importantly, FLD increases the risk of liver failure, diabetes and cancer and no pharmacological therapies exist for this detrimental disease. [More]
Research reveals two new genetic causes of neonatal diabetes

Research reveals two new genetic causes of neonatal diabetes

​Research by the University of Exeter Medical School has revealed two new genetic causes of neonatal diabetes. [More]
Hotspots of fuel consumption in adult brain also show key characteristics of developing brain

Hotspots of fuel consumption in adult brain also show key characteristics of developing brain

Although brain growth slows as individuals age, some regions of the brain continue to develop for longer than others, creating new connections and remodeling existing circuitry. [More]
Computer algorithm developed to identify genes that could be transformed to stop aging process

Computer algorithm developed to identify genes that could be transformed to stop aging process

Restricting calorie consumption is one of the few proven ways to combat aging. Though the underlying mechanism is unknown, calorie restriction has been shown to prolong lifespan in yeast, worms, flies, monkeys, and, in some studies, humans. [More]
Scientists identify protein complex essential for jumpstarting immune response during infection

Scientists identify protein complex essential for jumpstarting immune response during infection

St. Jude Children's Research Hospital scientists have identified a protein complex that is essential for jumpstarting the immune response during the critical first 24 hours of an infection. The research appears in the current issue of the scientific journal Immunity. [More]
Spaceflights cause cellular-level damage and may lead to long-term vision problems

Spaceflights cause cellular-level damage and may lead to long-term vision problems

Those who travel to space are rewarded with a beautiful sight - planet Earth. But the effects of space travel on the human sense of sight aren't so beautiful. More than 30 percent of astronauts who returned from two-week space shuttle missions and 60 percent who spent six months aboard the International Space Station were diagnosed with eye problems. Two recent investigations examined mechanisms that may explain eye changes in spaceflight, help find ways to minimize this health risk to astronauts and eventually prevent and treat eye diseases on Earth. [More]