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Neoantigen discovery sheds light on cancer immunogenicity

Researchers reported a proteogenomic approach to investigate fresh solid melanoma tumor material.

4 Aug 2023

Unveiling the key defender: PLSCR1 identified as a potent anti-SARS-CoV-2 factor in COVID-19 immunity

Researchers identified the anti-SARS-CoV-2 function of phospholipid scramblase 1 (PLSCR1).

14 Jul 2023

New study shows circulating anti-insulin CD4 T cells reflect progression of anti-islet immunity

In a recent study published in Science Translational Medicine, researchers profile antigen-specific helper clusters of differentiation 4-positive (CD4+) T-lymphocytes to determine anti-islet autoimmunity among mice and humans.

9 Jul 2023

Sphere Fluidics’ Pico-Mine platform chosen by Biosyntia to accelerate synthetic biology and metabolic workflows

Platform selected to accelerate precision fermentation workflows, to support more sustainable and cost-effective manufacturing for active ingredients in vitamins and bioactive.

From Sphere Fluidics 20 Jun 2023

Scientists unlock virus-fighting power with synthetic nanobody platform

Discovery and validation of nanobodies, a promising class of biologics, for viral infection prevention and treatment, including anti-SARS-CoV-2 nanobodies with enhanced neutralization properties through synergistic pairing. The study demonstrates the potential of nanobodies in developing effective therapies against viral infections.

8 Jun 2023

MFAP5, a microfibril-associated protein, unveiled as key player in scar formation and wound healing

MFAP5, a microfibril-associated protein, plays a significant role in wound healing by regulating fibroblast function, collagen deposition, and angiogenesis, suggesting its potential as a modulator of scar formation.

1 Jun 2023

A novel role for macrophage-activation signaling in orchestrating the recruitment process in response to the SARS-CoV-2 spike protein

Researchers derived peptides from the SARS-CoV-2 spike protein to assess COVID-19-associated inflammatory changes using zebrafish models.

19 May 2023

Researchers unravel processes that direct the development of astrocyte structure

Researchers at Baylor College of Medicine have unraveled the processes that give astrocytes, the most abundant glial cell in the brain, their special bushy shape, which is fundamental for brain function.

26 Apr 2023

Neutrophils found to play a key role in fibromyalgia pain

Targeting neutrophil activity and interactions with sensory neurons may be a potential approach for treating fibromyalgia pain.

25 Apr 2023

A rapid and affordable in vitro model to test SARS-CoV-2 susceptibility in animal species

Research investigates the susceptibility of seven bat species to SARS-CoV-2 by expressing their ACE2 receptor in a non-permissive avian cell line. The study found that all seven bat species were susceptible to SARS-CoV-2, but the level of virus replication differed between bat species and virus variants.

24 Apr 2023

New computational method identifies routes of cellular differentiation in acute myeloid leukemia

Researchers have developed a new method to distinguish between cancerous and healthy stem cells and progenitor cells from samples of patients with acute myeloid leukemia (AML), a disease driven by malignant blood stem cells that have historically been difficult to identify.

24 Apr 2023

Isolating tumor-reactive blood cells to treat cancers

Adoptive cell therapy (ACT) has become a promising immunotherapy tool to help treat advanced melanoma.

10 Apr 2023

Beclin-1 plays a key role in endometrial reprogramming for successful establishment of pregnancy

Throughout a woman's reproductive life, the endometrium, the mucous membrane lining the uterus, goes through cyclical remodeling. It thickens during the menstrual cycle in preparation for embryo implantation, and it is shed during menstruation when there is no fertilization.

10 Apr 2023

Orbit Discovery and Evergreen Discovery collaborate to discover peptides for targeting radiopharmaceuticals

Evergreen Discovery (Evergreen), a leading radiopharmaceutical drug development company with a focus on the treatment and diagnosis of cancer.

From Orbit Discovery 3 Apr 2023

Researchers report surprising first steps that promote resistance to commonly prescribed antibiotics

Antibiotic resistance is a global health threat. In 2019 alone, an estimated 1.3 million deaths were attributed to antibiotic resistant bacterial infections worldwide.

31 Mar 2023

Engineering epitope scaffolds of conserved regions of SARS-CoV-2 spike

In a recent study posted to the bioRxiv* preprint server, researchers engineered epitope scaffolds (ESs) of conserved regions of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein.

3 Mar 2023

Antiverse raises funding and demonstrates therapeutic antibody identification with AI-driven drug discovery platform

Antiverse Ltd (Antiverse), a biotechnology company developing a computational antibody drug discovery platform, today announced the successful identification of functional antibody clusters targeting two G-protein-coupled receptors (GPCRs), both displaying versatile binding profiles and nanomolar affinity.

From Antiverse 1 Mar 2023