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Cerebrovascular disease is a group of brain dysfunctions related to disease of the blood vessels supplying the brain. Hypertension is the most important cause; it damages the blood vessel lining, endothelium, exposing the underlying collagen where platelets aggregate to initiate a repairing process which is not always complete and perfect. Sustained hypertension permanently changes the architecture of the blood vessels making them narrow, stiff, deformed, uneven and more vulnerable to fluctuations in blood pressure.
Penn researchers discover molecular mechanism that underlies common cerebrovascular disease

Penn researchers discover molecular mechanism that underlies common cerebrovascular disease

Cerebral cavernous malformations (CCMs) are clusters of dilated, thin-walled blood vessels in the brain that can cause stroke and seizures, yet exactly how they form is somewhat of a mystery. Now, a team from the Perelman School of Medicine at the University of Pennsylvania has discovered the molecular mechanism that underlies this common cerebrovascular disease. They published their results this week online ahead of print in Nature. [More]
Orexigen Therapeutics, Valeant Pharmaceuticals sign distribution agreement for Mysimba

Orexigen Therapeutics, Valeant Pharmaceuticals sign distribution agreement for Mysimba

Orexigen Therapeutics, Inc. today announced Valeant Pharmaceuticals International, Inc. will commercialize Mysimba (naltrexone HCl / bupropion HCl prolonged release) in Central and Eastern Europe. [More]
Diffusion tensor imaging ‘should be routine’ in SVD assessment

Diffusion tensor imaging ‘should be routine’ in SVD assessment

Gait speed and microstructural brain damage may be the best indicators of mortality risk in patients with small vessel disease, say researchers. [More]
Common mortality causes prevail in epilepsy patients

Common mortality causes prevail in epilepsy patients

A prospective, community-based study confirms that patients with epilepsy usually die of the same causes as other people. [More]
APOE ε4 predicts risk of future depression

APOE ε4 predicts risk of future depression

One of the most powerful predictors in neuropsychiatry is the epsilon 4 (ε4) allele of the apolipoprotein gene (APOE). [More]
Very long-term outcomes of childhood onset epilepsy reported

Very long-term outcomes of childhood onset epilepsy reported

A study in Epilepsia presents seizure remission outcomes as well as detailed clinical and neurological findings from a minimum 45-year follow-up of a Finnish cohort of individuals with childhood-onset epilepsy. [More]
New studies analyse life expectancy, causes of death and child mortality in different regions of China

New studies analyse life expectancy, causes of death and child mortality in different regions of China

Two new studies, published in The Lancet, reveal for the first time how health in different regions of China has changed in recent decades. [More]
Localisation of policies crucial to China's health reforms, new studies suggest

Localisation of policies crucial to China's health reforms, new studies suggest

Two new studies, published in The Lancet, reveal for the first time how health in different regions of China has changed in recent decades. The articles analyse life expectancy, causes of death, and child mortality for 31 provinces, municipalities, autonomous regions of China, and Hongkong and Macao special administrative regions, finding that in the last two decades, life expectancy has risen, and deaths in children under 5 years have fallen, in every province. [More]
CML arterial adverse events rate dependent on TKI choice

CML arterial adverse events rate dependent on TKI choice

The risk of major arterial adverse events in chronic myeloid leukaemia patients may significantly differ between tyrosine kinase inhibitors, suggests a meta-analysis published in Leukemia & Lymphoma. [More]
Treatment with life-saving medications increases in IHD but levels still suboptimal

Treatment with life-saving medications increases in IHD but levels still suboptimal

Treatment with life-saving medications has increased over the past ten years in ischaemic heart disease but levels are still suboptimal, according to the first results of the Chronic Ischaemic Cardiovascular Disease (CICD) Pilot Registry presented today at ESC Congress 2015 and published in European Heart Journal. [More]
Carbonated beverage consumption associated with out-of-hospital cardiac arrests of cardiac origin

Carbonated beverage consumption associated with out-of-hospital cardiac arrests of cardiac origin

Carbonated beverages are associated with out-of-hospital cardiac arrests of cardiac origin, according to results from the All-Japan Utstein Registry presented for the first time today at ESC Congress. [More]
Despite increased life expectancy, British people suffer from more medical ailments

Despite increased life expectancy, British people suffer from more medical ailments

People in the UK are living longer but are coping with more medical ailments causing illness or disability in their older years, according to a major new international study published in The Lancet today (Thursday 27 August). [More]
Childhood cancer survivors have high risk of suffering stroke at young age

Childhood cancer survivors have high risk of suffering stroke at young age

Most people assume strokes only happen to octogenarians, but recent evidence suggests that survivors of childhood cancer have a high risk of suffering a stroke at a surprisingly young age. [More]
FDA accepts Chiasma's NDA filing for octreotide capsules for treatment of adult patients with acromegaly

FDA accepts Chiasma's NDA filing for octreotide capsules for treatment of adult patients with acromegaly

Chiasma, Inc., a U.S. late-stage biopharmaceutical company, today announced that the U.S. Food and Drug Administration has accepted for filing the Company's New Drug Application (NDA) for the marketing and sale of octreotide capsules, an oral drug proposed for the maintenance therapy of adult patients with acromegaly. [More]
Loyola stroke expert co-edits new textbook on cerebrovascular disease

Loyola stroke expert co-edits new textbook on cerebrovascular disease

Loyola University Chicago Stritch School of Medicine professor and chair of the Department of Neurology, José Biller, MD, an internationally known expert on stroke, is co-editor of a major new textbook, Common Pitfalls in Cerebrovascular Disease. [More]
Hiroshima University researchers study promising biomarker for severity of ARWMCs, endothelial function

Hiroshima University researchers study promising biomarker for severity of ARWMCs, endothelial function

A promising biomarker for the severity of age-related white matter changes (ARWMCs) and endothelial function was evaluated at Hiroshima University, Japan. The relationship between this biomarker, the telomeric 3'-overhang (G-tail) length, and cardiovascular risk in humans is unclear so far. [More]
Brain changes reflect higher risk of cerebrovascular disease in women who experience more hot flashes

Brain changes reflect higher risk of cerebrovascular disease in women who experience more hot flashes

Women who experience more hot flashes, particularly while sleeping, during the menopause transition are more likely to have brain changes reflecting a higher risk for cerebrovascular disease, such as stroke and other brain blood flow problems, according to a pilot study led by researchers at the University of Pittsburgh School of Medicine published online today in Menopause and funded by the National Institutes of Health. [More]
Orexigen Therapeutics provides update on business and financial results for Q1 2015

Orexigen Therapeutics provides update on business and financial results for Q1 2015

Orexigen Therapeutics, Inc. today announced business and financial results for the first quarter ended March 31, 2015. [More]
UT Southwestern's new operating suite integrates surgical and endovascular techniques in one space

UT Southwestern's new operating suite integrates surgical and endovascular techniques in one space

UT Southwestern Medical Center has established a Hybrid Cerebrovascular Operating Suite at Zale Lipshy University Hospital that will combine surgical innovations with advanced imaging capabilities for surgical cases related to stroke and brain aneurysms. [More]
Montefiore and Einstein researchers to present new findings on neurological disorders at AAN 2015

Montefiore and Einstein researchers to present new findings on neurological disorders at AAN 2015

Researchers from Montefiore Health System and Albert Einstein College of Medicine will present new findings on how to effectively treat migraine, and forecast the onset of pain in a number of neurological conditions including dementia in older adults. [More]
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