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Cerebrovascular disease is a group of brain dysfunctions related to disease of the blood vessels supplying the brain. Hypertension is the most important cause; it damages the blood vessel lining, endothelium, exposing the underlying collagen where platelets aggregate to initiate a repairing process which is not always complete and perfect. Sustained hypertension permanently changes the architecture of the blood vessels making them narrow, stiff, deformed, uneven and more vulnerable to fluctuations in blood pressure.
Loyola stroke expert co-edits new textbook on cerebrovascular disease

Loyola stroke expert co-edits new textbook on cerebrovascular disease

Loyola University Chicago Stritch School of Medicine professor and chair of the Department of Neurology, José Biller, MD, an internationally known expert on stroke, is co-editor of a major new textbook, Common Pitfalls in Cerebrovascular Disease. [More]
Hiroshima University researchers study promising biomarker for severity of ARWMCs, endothelial function

Hiroshima University researchers study promising biomarker for severity of ARWMCs, endothelial function

A promising biomarker for the severity of age-related white matter changes (ARWMCs) and endothelial function was evaluated at Hiroshima University, Japan. The relationship between this biomarker, the telomeric 3'-overhang (G-tail) length, and cardiovascular risk in humans is unclear so far. [More]
Brain changes reflect higher risk of cerebrovascular disease in women who experience more hot flashes

Brain changes reflect higher risk of cerebrovascular disease in women who experience more hot flashes

Women who experience more hot flashes, particularly while sleeping, during the menopause transition are more likely to have brain changes reflecting a higher risk for cerebrovascular disease, such as stroke and other brain blood flow problems, according to a pilot study led by researchers at the University of Pittsburgh School of Medicine published online today in Menopause and funded by the National Institutes of Health. [More]
Orexigen Therapeutics provides update on business and financial results for Q1 2015

Orexigen Therapeutics provides update on business and financial results for Q1 2015

Orexigen Therapeutics, Inc. today announced business and financial results for the first quarter ended March 31, 2015. [More]
UT Southwestern's new operating suite integrates surgical and endovascular techniques in one space

UT Southwestern's new operating suite integrates surgical and endovascular techniques in one space

UT Southwestern Medical Center has established a Hybrid Cerebrovascular Operating Suite at Zale Lipshy University Hospital that will combine surgical innovations with advanced imaging capabilities for surgical cases related to stroke and brain aneurysms. [More]
Montefiore and Einstein researchers to present new findings on neurological disorders at AAN 2015

Montefiore and Einstein researchers to present new findings on neurological disorders at AAN 2015

Researchers from Montefiore Health System and Albert Einstein College of Medicine will present new findings on how to effectively treat migraine, and forecast the onset of pain in a number of neurological conditions including dementia in older adults. [More]
TOAST classification remains effective, easy-to-use system to classify strokes

TOAST classification remains effective, easy-to-use system to classify strokes

In 1993, neurologists Harold P. Adams Jr., MD, and Jose Biller, MD, and colleagues proposed a new way to classify strokes. It became known as the TOAST classification. Twenty-two years later, the TOAST classification remains an effective and easy-to-use system that is routinely employed in stroke studies around the world, Drs. Adams and Biller report in the journal Stroke, published online ahead of print. [More]
Chiasma closes $70 million Series E financing round

Chiasma closes $70 million Series E financing round

Chiasma, Inc., a U.S. privately-held biopharma company developing octreotide capsules, its lead product for the orphan condition acromegaly, today announced the closing of a $70 million Series E financing round. [More]
Researchers find key protein critical to the success of common anti-platelet drug Plavix

Researchers find key protein critical to the success of common anti-platelet drug Plavix

Researchers at the UNC School of Medicine have found that the blood platelet protein Rasa3 is critical to the success of the common anti-platelet drug Plavix, which breaks up blood clots during heart attacks and other arterial diseases. [More]
Chiasma announces publication of octreotide capsules Phase III study results in JCEM

Chiasma announces publication of octreotide capsules Phase III study results in JCEM

Chiasma Inc., a U.S. privately-held biopharma company, announced today that results from a multicenter Phase III study of the investigational new drug, octreotide capsules, were published online for early release on Feb. 9, ahead of print, by the Journal of Clinical Endocrinology & Metabolism. [More]
Vascular and Alzheimer's-related brain abnormalities cause dementia in older people

Vascular and Alzheimer's-related brain abnormalities cause dementia in older people

A growing body of research suggests that the most common cause of dementia in older people is a mix of vascular and Alzheimer's-related brain abnormalities, and that approximately half of people who die with Alzheimer's also have evidence of strokes in their brains. Furthermore, when strokes and hallmark Alzheimer's plaques and tangles are combined, it increases a person's likelihood of experiencing dementia. [More]
Lack of information increases depression risk in people recovering from stroke

Lack of information increases depression risk in people recovering from stroke

People recovering from a stroke and living at home have generally a higher risk of suffering from depression. According to researchers lack of information is often a major concern for patients and this frequently contributes to their depression. This is the result of a new study from health sociologists of the University of Luxembourg. [More]
Hydroxyurea therapy offers safe, effective disease management of SCA

Hydroxyurea therapy offers safe, effective disease management of SCA

Conclusive data show that hydroxyurea therapy offers safe and effective disease management of sickle cell anemia (SCA) and reduces the risk of stroke, prompting early termination by the National Heart Lung and Blood Institute of a key clinical trial studying the drug's efficacy. [More]
Janssen announces submission of NDA for three-month paliperidone palmitate

Janssen announces submission of NDA for three-month paliperidone palmitate

Janssen Research & Development, LLC today announced the submission of a New Drug Application (NDA) for three-month atypical antipsychotic paliperidone palmitate to the U.S. Food and Drug Administration. The NDA seeks approval for the medication as a treatment for schizophrenia in adults. [More]
Impaired brain circulation in African Americans can increase risk of cerebrovascular disease

Impaired brain circulation in African Americans can increase risk of cerebrovascular disease

Researchers at The University of Texas have found that compared to Caucasian Americans, African Americans have impaired blood flow regulation in the brain that could contribute to a greater risk of cerebrovascular diseases such as stroke, transient ischaemic attack ("mini stroke"), subarachnoid haemorrhage or vascular dementia. [More]
Early brain imaging studies may help prevent vascular diseases

Early brain imaging studies may help prevent vascular diseases

Future prevention and treatment strategies for vascular diseases may lie in the evaluation of early brain imaging tests long before heart attacks or strokes occur, according to a systematic review conducted by a team of cardiologists, neuroscientists, and psychiatrists from Icahn School of Medicine at Mount Sinai and published in the October issue of JACC Cardiovascular Imaging. [More]
UH's Neurological Institute designated as Gold Center of Excellence

UH's Neurological Institute designated as Gold Center of Excellence

The Neurological Institute at University Hospitals has been designated as a Gold Center of Excellence (COE) and featured as a top performing center by NeuStrategy, Inc., a Chicago consulting firm providing strategic support to neuroscience, oncology and orthopaedic service providers. [More]
Migraine in middle age linked to Parkinson's disease

Migraine in middle age linked to Parkinson's disease

A paper recently published in American Academy of Neurology suggests that migraine in middle age may indicate an increased risk of developing a movement disorder, such as Parkinson’s disease. The study also showed that people who experienced migraine with aura were twice as likely to develop Parkinson’s disease compared with those who did not suffer from headaches. [More]
FDA approves Contrave extended-release tablets for chronic weight management

FDA approves Contrave extended-release tablets for chronic weight management

Takeda Pharmaceuticals U.S.A., Inc. and Orexigen® Therapeutics, Inc. jointly announced today that the U.S. Food and Drug Administration has approved Contrave® extended-release tablets as an adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in adults with an initial body mass index of 30 kg/m2 or greater (obese), or 27 kg/m2 or greater (overweight) in the presence of at least one weight-related comorbid condition. [More]
FDA approves Epaned for treatment of symptomatic and asymptomatic heart failure

FDA approves Epaned for treatment of symptomatic and asymptomatic heart failure

Silvergate Pharmaceuticals, Inc., focused on the development and commercialization of innovative and safe medicines for children, today announced that the United States Food and Drug Administration approved Epaned for the treatment of symptomatic heart failure and the treatment of asymptomatic left ventricular dysfunction (to decrease the rate of development of overt heart failure and to reduce hospitalization for heart failure). [More]
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