Chemokine News and Research

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Chemokines are a family of small cytokines, or proteins secreted by cells. Proteins are classified as chemokines according to shared structural characteristics such as small size (they are all approximately 8-10 kilodaltons in size), and the presence of four cysteine residues in conserved locations that are key to forming their 3-dimensional shape.

Study reports the first protein-based diagnostic signature to discriminate MIS-C from Kawasaki Disease and other common infections

Researchers explore the distinguishing features of MIS-C as compared to other inflammatory-infectious syndromes in children.

4 Aug 2023

Intranasal inoculation study sheds light on nasal and systemic immune responses to SARS-CoV-2

Study reveals the events accompanying the COVID-19 infection cascade in the nasal mucosa and free circulation

1 Aug 2023

Study identifies potential immune biomarker for pulmonary tuberculosis: a step towards early detection

Researchers have identified a potential immune biomarker associated with pulmonary TB in active patients compared to controls.

19 Jul 2023

Investigating the role of T-cell immunity in long COVID

Researchers investigates the persistence of symptoms and the immune response in patients recovering from COVID-19.

13 Jul 2023

New study shows circulating anti-insulin CD4 T cells reflect progression of anti-islet immunity

In a recent study published in Science Translational Medicine, researchers profile antigen-specific helper clusters of differentiation 4-positive (CD4+) T-lymphocytes to determine anti-islet autoimmunity among mice and humans.

9 Jul 2023

Australian rainforest remedies: Scientists explore bioactive plant compounds as potential anti-neuroinflammatory agents

Research discusses the process of discovering anti-inflammatory and neuroprotective drugs from medicinal plants found in the Australian rainforest. It focuses on the pathways from the discovery of bioactive plants to the validation in an appropriate neuro-inflammatory mouse model, using some examples from their current research.

9 Jul 2023

Study shows promising prospects for automating 3D-DSRT in drug testing

The June 2023 issue of SLAS Discovery contains one review article, five full-length articles and two technical briefs covering spheroid models, 3D cell high-throughput screening (HTS) applications for treating Alzheimer's and other drug discovery research.

29 Jun 2023

mRNA rabies vaccine induces durable immune response in macaques

Novel mRNA vaccine for rabies shows enhanced immune response with higher antibody levels and improved cross-neutralization, indicating potential for a broadly protective vaccine against related lyssavirus strains.

26 Jun 2023

Breakthrough discovery could lead to new treatments for brain metastases

When cancer that starts in the body metastasizes to the brain, it is almost always lethal, in part because so few treatment options exist. Now a new study by Wistar scientists published in Nature Communications shows that a type of brain cell called astrocytes plays an important role in promoting brain metastasis by recruiting a specific subpopulation of immune cells.

24 Jun 2023

Unlocking HIV cure: Study highlights allogeneic immunity as key mechanism in eradicating latent virus reservoirs

Allogeneic stem cell transplantation with CCR5Δ32/Δ32 donors shows potential for HIV cure. Alloimmunity and CCR5 deficiency play significant roles in viral reservoir clearance.

19 Jun 2023

Trained immunity: its role in COVID-19 and potential in preparing for future infectious outbreaks

Researchers reported on the contribution of trained immune responses to protection against SARS-CoV-2 infections and future pandemics.

16 Jun 2023

Breaking barriers: hydrogel reservoir unleashes the potential of HSV-1 virotherapy in cancer

Researchers evaluated the therapeutic efficacy of Navoximod.

13 Jun 2023

Bamboo's hidden treasures: unveiling the possible health-boosting powers of leaf and sheath extracts

Researchers explored the antioxidant and anti-inflammatory properties of bamboo leaves and sheaths.

13 Jun 2023

Two studies seek to understand the drivers of chronic and progressive phase of COVID-19

Early studies of COVID-19 focused on the acute phase of the disease. However, attention has now turned to the long-term consequences of the disease, which are also significant causes of morbidity and mortality.

6 Jun 2023

New insight into how click chemistry EV/peptide/chemokine nanomissiles repair CNS injuries

This new article publication from Acta Pharmaceutica Sinica B, discusses click chemistry extracellular vesicle/peptide/chemokine nanocarriers for treating central nervous system injuries.

31 May 2023

Lipid-degrading enzyme, fatty acid amide hydrolase is a predictor of long-term survival in patients with breast cancer

Scientists have identified a lipid-degrading enzyme as a prognostic biomarker for luminal breast cancer.

31 May 2023

Treatment with modified lactic acid bacteria accelerates the healing of wounds, study shows

Complicated, hard-to-heal wounds are a growing medical problem and there are currently only two drugs approved with proven efficacy.

30 May 2023

Mental health profoundly impacts inflammatory responses in the body

Study uncovered mechanisms by which psychological stress affects bowel inflammation.

30 May 2023

T-cell-inducing mRNA COVID-19 vaccine improves effectiveness

Researchers develop a lipid nanoparticle-formulated mRNA-based antigen encoding three SARS-CoV-2 peptides derived from non-structural proteins.

25 May 2023

COVID-19 'bites the apple': Abdominal obesity ignites cytokine storm

Abdominal obesity increases the risk of severe COVID-19 and mortality due to heightened inflammatory responses, according to a study on Japanese patients and a murine COVID-19 model. Blocking inflammatory cytokines and preventing obesity may improve survival rates.

24 May 2023