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Cholesterol is a waxy, fat-like substance made in the liver, and found in the blood and in all cells of the body. Cholesterol is important for good health and is needed for making cell walls, tissues, hormones, vitamin D, and bile acid. Cholesterol also comes from eating foods taken from animals such as egg yolks, meat, and whole-milk dairy products. Too much cholesterol in the blood may build up in blood vessel walls, block blood flow to tissues and organs, and increase the risk of developing heart disease and stroke.
LMU researchers reveal how crystalline deposits induce cell death

LMU researchers reveal how crystalline deposits induce cell death

Crystal formation plays a defining role in the pathogenesis of a range of common diseases, such as gout and atherosclerosis. Ludwig-Maximilians-Universitaet (LMU) in Munich researchers led by Hans-Joachim Anders have now elucidated how the insoluble deposits induce cell death. [More]
Second-hand smoke exposure linked to larger waist, poorer cognition in children

Second-hand smoke exposure linked to larger waist, poorer cognition in children

Exposure to second-hand smoke is associated with a larger waist and poorer cognition in children, researchers say. [More]
Cardiovascular considerations crucial for CML TKI patients

Cardiovascular considerations crucial for CML TKI patients

A review of BCR–ABL1 tyrosine kinase inhibitors highlights the need to consider cardiovascular adverse event risk profiles when prescribing for patients with chronic myeloid leukaemia. [More]
Amgen announces approval of cholesterol-lowering medication Repatha (evolocumab) Injection in Japan

Amgen announces approval of cholesterol-lowering medication Repatha (evolocumab) Injection in Japan

Amgen today announced that the Japanese Ministry of Health, Labour and Welfare has approved the cholesterol-lowering medication Repatha (evolocumab) Injection, the first proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor to be approved in Japan. [More]
Using statins before and after heart surgery can help reduce cardiac complications, mortality risks

Using statins before and after heart surgery can help reduce cardiac complications, mortality risks

Using statins before and after coronary artery bypass grafting (CABG) surgery can help reduce cardiac complications, such as atrial fibrillation, following surgery and also can reduce the risk of death during and after surgery, according to a review article posted online today by The Annals of Thoracic Surgery. [More]
Cholesterol-lowering drug simvastatin could become effective treatment for Parkinson's

Cholesterol-lowering drug simvastatin could become effective treatment for Parkinson's

A clinical trial using cholesterol-lowering treatment Simvastatin in people living with Parkinson's is getting underway in centres across the country -- with the hope that it could become one of a number of effective treatments available to treat Parkinson's. [More]
Higher-fat DASH diet significantly reduces blood pressure and triglycerides

Higher-fat DASH diet significantly reduces blood pressure and triglycerides

The Dietary Approaches to Stop Hypertension (DASH) dietary pattern, which is high in fruits, vegetables and low fat dairy foods, significantly lowers blood pressure as well as low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol. [More]
New federal dietary guidelines recommend day-to-day pattern of healthy eating

New federal dietary guidelines recommend day-to-day pattern of healthy eating

New federal dietary guidelines announced on Thursday for the first time recommend Americans eat far less sugar and focus on a day-to-day pattern of eating a variety of nutritious, balanced foods. [More]
Intelligent Labs launches Ultra Pure Omega 3 fish oil in the UK

Intelligent Labs launches Ultra Pure Omega 3 fish oil in the UK

Intelligent Labs a premium supplement company today announced the launch in the UK of their Ultra Pure Omega 3, after launching in the US this summer to great success. They believe their Ultra Pure Omega 3 will be the strongest and most effective Omega 3 fish oil available in the UK. [More]
Family income matters more than race in predicting obesity in children

Family income matters more than race in predicting obesity in children

For a long time researchers have tracked high rates of obesity among black and Hispanic kids, but a closer look at communities shows family income matters more than race in predicting which kids are overweight. [More]
CUMC study reveals statins may help reduce heart disease risk in people with sleep apnea

CUMC study reveals statins may help reduce heart disease risk in people with sleep apnea

A new study conducted at Columbia University Medical Center has revealed some of the underlying mechanisms that may increase the risk of heart disease in people with sleep apnea. The study also found that statins -- the cholesterol-lowering medications commonly prescribed to combat heart disease -- may help reverse this process. [More]
Statins could be effective against metastatic small cell lung cancer

Statins could be effective against metastatic small cell lung cancer

In a recent study, researchers at Cancer Treatment Centers of America at Western Regional Medical Center (Western), in collaboration with international colleagues, found that statins could be an effective therapeutic against metastatic small cell lung cancer (SCLC). [More]
Common antibiotics can promote C. diff infections by killing off bile acid-altering microbes

Common antibiotics can promote C. diff infections by killing off bile acid-altering microbes

New research from North Carolina State University and the University of Michigan finds that bile acids which are altered by bacteria normally living in the large intestine inhibit the growth of Clostridium difficile, or C. diff. C. diff is a harmful bacterium that can cause painful and sometimes fatal infections. [More]
Millendo signs license agreement, secures funding to test new drugs for treatment of endocrine disorders

Millendo signs license agreement, secures funding to test new drugs for treatment of endocrine disorders

Millendo Therapeutics, a University of Michigan startup company, announced an exclusive license agreement with AstraZeneca for the worldwide development and commercialization rights to test a new compound, MLE4901, for the treatment of polycystic ovary syndrome. [More]
Study finds gaps in consumer understanding of their health information

Study finds gaps in consumer understanding of their health information

According to HealthMine's research, conducted with more than 6,000 consumers enrolled in health plans in 2015, 53% of consumers said it's not easy to understand their health information, or what they need to do to maintain or improve their health. Yet, wellness programs have the potential to discover sick and at-risk members in the population; 46% of consumers with a chronic condition who were surveyed said they discovered their illness through a wellness program. [More]
NEJM publishes results of Cosentyx Phase III studies in ankylosing spondylitis

NEJM publishes results of Cosentyx Phase III studies in ankylosing spondylitis

Novartis announced today that the results of the MEASURE 1 and MEASURE 2 Phase III studies for Cosentyx® (secukinumab) in ankylosing spondylitis (AS) were published in The New England Journal of Medicine (NEJM). These pivotal studies demonstrated significant clinical improvements with Cosentyx versus placebo in reducing the signs and symptoms of active AS – a long-term, painful and debilitating inflammation of the spine. [More]
Evolocumab drug offers no added benefit over appropriate comparator therapy

Evolocumab drug offers no added benefit over appropriate comparator therapy

Evolocumab (trade name: Repatha) has been approved since July 2015 for two therapeutic indications: on the one hand, for hypercholesterolaemia or mixed dyslipidaemia, and on the other, for homozygous familial hypercholesterolaemia. [More]
Cholesterol essential for health, but also plays key role in longevity

Cholesterol essential for health, but also plays key role in longevity

Animals from tiny worms to human beings have a love-hate relationship with fats and lipids. Cholesterol is a famous example of how they are both essential for health and often have a role in death. [More]
Variant signs worldwide exclusive license and development agreement with L&F Research

Variant signs worldwide exclusive license and development agreement with L&F Research

Variant Pharmaceuticals, Inc., an emerging pharmaceutical company focusing on rare diseases and other specialty conditions with limited or sub-optimal therapeutic options, announced today a worldwide exclusive license and development agreement with L&F Research LLC to advance development of Variant's lead product, VAR 200. [More]
New mobile app empowers individuals to assess, enhance daily overall heart health

New mobile app empowers individuals to assess, enhance daily overall heart health

Leading cardiologist Valentin Fuster, MD, PhD, has developed a free mobile application called "Circle of Health" to empower individuals around the globe to take action to comprehensively assess and enhance their daily overall heart health. Cardiovascular diseases are the number one cause of mortality in the world. [More]
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