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Cholesterol is a waxy, fat-like substance made in the liver, and found in the blood and in all cells of the body. Cholesterol is important for good health and is needed for making cell walls, tissues, hormones, vitamin D, and bile acid. Cholesterol also comes from eating foods taken from animals such as egg yolks, meat, and whole-milk dairy products. Too much cholesterol in the blood may build up in blood vessel walls, block blood flow to tissues and organs, and increase the risk of developing heart disease and stroke.
Depression combined with behavioral, metabolic symptoms increases risk of type 2 diabetes

Depression combined with behavioral, metabolic symptoms increases risk of type 2 diabetes

Depression may compound the risk of developing type 2 diabetes in people with such early warning signs of metabolic disease as obesity, high blood pressure and unhealthy cholesterol levels, according to researchers from McGill University, l'Université de Montréal, the Institut de recherches cliniques de Montréal and the University of Calgary. [More]
New sensitive detection method could help measure subfractions of HDL

New sensitive detection method could help measure subfractions of HDL

High-density lipoprotein (HDL) is often referred to as good cholesterol: high levels of HDL are associated with lower risk of cardiovascular disease. But many clinical outcome trials for drugs that raise HDL levels have failed to show significant benefits for trial participants. [More]
Cyclodextrin dissolves cholesterol crystals, reduces atherosclerotic plaques

Cyclodextrin dissolves cholesterol crystals, reduces atherosclerotic plaques

Cardiovascular disease from atherosclerosis is one of the most common causes of death worldwide. Inflammation plays a crucial role in atherosclerosis and cholesterol crystals are considered to be early triggers in the development of the disease. [More]
Study finds how tumour cells grow through scavenging bad cholesterol

Study finds how tumour cells grow through scavenging bad cholesterol

Several studies have recognized a link between obesity and cancer. Richard Lehner, professor of Pediatrics and investigator at the University of Alberta's Faculty of Medicine & Dentistry, has taken his research further to understand how tumour cells grow through scavenging very low-density lipoproteins (VLDL) and low-density lipoproteins (LDL), commonly known as the "bad cholesterol", and what mechanisms can be used to reduce the malignant cells' growth. [More]
Metabolic pathway activates cell signaling protein to promote breast cancer metastasis

Metabolic pathway activates cell signaling protein to promote breast cancer metastasis

A metabolic pathway that is up-regulated in certain breast cancers promotes the disease's progression by activating a cell signaling protein called Arf6, according to a paper published in the Journal of Cell Biology. [More]
Health benefits of gastric bypass surgery start soon after procedure

Health benefits of gastric bypass surgery start soon after procedure

The health benefits of Roux-en Y gastric bypass surgery—a surgical weight-loss procedure in which the stomach is made smaller—start soon after the procedure. New research presented today at the Experimental Biology 2016 meeting in San Diego found that patients who underwent the procedure already showed some reductions in weight, waist circumference and body mass index one week after the procedure. [More]
Person's age, mobility could be powerful predictors of survival than certain biomarkers

Person's age, mobility could be powerful predictors of survival than certain biomarkers

Advances in technology allow scientists to measure intricate details about the human body that greatly enhance understanding of health, disease and aging. [More]
Scientists find new way to inhibit growth of tuberculosis-causing bacterium

Scientists find new way to inhibit growth of tuberculosis-causing bacterium

Scientists at the The University of Queensland and the University of California San Francisco have found a new way to inhibit the growth of the bacterium that causes tuberculosis (TB). [More]
Better management of blood sugar, blood pressure and LDL-cholesterol levels could reduce cardiovascular risk

Better management of blood sugar, blood pressure and LDL-cholesterol levels could reduce cardiovascular risk

While controlling blood pressure, blood sugar and LDL-cholesterol levels reduces the risk of cardiovascular disease in people with diabetes, only 7 percent of diabetic participants in three major heart studies had recommended levels of these three factors, according to research from the Heart Disease Prevention Program at the University of California, Irvine School of Medicine. [More]
Researchers identify possible genetic basis for coronary artery disease

Researchers identify possible genetic basis for coronary artery disease

For many people, coronary artery disease, or CAD—the buildup of plaque in the heart's arteries—is an unfortunate part of aging. By studying the genetic makeup of those who manage to maintain clear arteries into old age, researchers have identified a possible genetic basis for the disease, as well as potential new opportunities to prevent it. [More]
Regular exercise can stave off health problems associated with sedentary time

Regular exercise can stave off health problems associated with sedentary time

Office workers can stave off health problems associated with sitting down all day by regularly exercising, a new study has found. [More]
Adding liraglutide to diet and exercise plan may help people lose weight, reduce diabetes risk

Adding liraglutide to diet and exercise plan may help people lose weight, reduce diabetes risk

For people with prediabetes who are overweight or obese, adding 3.0 mg of liraglutide for three years to a diet and exercise plan may lead to major health improvements, new industry-sponsored research suggests. The results will be presented Monday, April 4, at ENDO 2016, the annual meeting of the Endocrine Society, in Boston. [More]
Evolocumab could be more effective than ezetimibe in lowering cholesterol in statin-intolerant patients

Evolocumab could be more effective than ezetimibe in lowering cholesterol in statin-intolerant patients

In the first major trial of its kind, Cleveland Clinic researchers used a blinded rechallenge with atorvastatin or placebo to objectively confirm the presence of muscle-related symptoms in patients with a history of intolerance to multiple statins and found that evolocumab (a PCSK9 inhibitor) was a more effective option to lower cholesterol than ezetimibe in these patients. [More]
Daily walnut consumption positively impacts blood cholesterol levels in older adults

Daily walnut consumption positively impacts blood cholesterol levels in older adults

Initial findings from the Walnuts and Healthy Aging study presented at Experimental Biology 2016 (EB) indicate that daily walnut consumption positively impacts blood cholesterol levels without adverse effects on body weight among older adults. [More]
Apple body shape linked to higher heart risk than pear-shape in diabetics

Apple body shape linked to higher heart risk than pear-shape in diabetics

People with type 1 or 2 diabetes who have apple-shaped bodies with excessive fat around the abdomen and stomach, can be at higher risk of serious heart disease than patients with pear-shaped figures who store excess fat around their hips, according to a new study from Intermountain Medical Center Heart Institute and John Hopkins University. [More]
Study demonstrates rarity of familial hypercholesterolemia mutations in individuals with high cholesterol

Study demonstrates rarity of familial hypercholesterolemia mutations in individuals with high cholesterol

Only a small fraction of people with very high cholesterol can attribute their condition to a genetic mutation related to familial hypercholesterolemia, but individuals with these mutations face a high risk of developing early-onset coronary artery disease, according to research presented at the American College of Cardiology's 65th Annual Scientific Session. [More]
Researchers compare lipid-lowering efficacy for two nonstatin therapies in statin-intolerant patients

Researchers compare lipid-lowering efficacy for two nonstatin therapies in statin-intolerant patients

Steven E. Nissen, M.D., of the Cleveland Clinic, and colleagues identified patients with muscle-related adverse effects from statins and compared lipid-lowering efficacy for two nonstatin therapies, ezetimibe and evolocumab. The study was published online by JAMA, and is being released to coincide with its presentation at the American College of Cardiology's 65th Annual Scientific Session & Expo. [More]
Cholesterol drug evacetrapib fails to reduce risk of cardiovascular events

Cholesterol drug evacetrapib fails to reduce risk of cardiovascular events

Despite lowering low-density lipoprotein (LDL), known as "bad" cholesterol, while markedly increasing levels of high-density lipoprotein (HDL), or "good" cholesterol, a large clinical trial to investigate the cholesterol drug evacetrapib was discontinued early after a preliminary analysis showed it did not reduce rates of major adverse cardiovascular events, according to research presented at the American College of Cardiology's 65th Annual Scientific Session. [More]
DNA changes may affect a person's lifespan

DNA changes may affect a person's lifespan

Scientists have identified DNA changes that can cut a person's lifespan by up to three years. [More]
Eating pulses helps people lose weight, show researchers

Eating pulses helps people lose weight, show researchers

Eating just one serving of pulses a day is enough to help people lose weight and keep that weight off, according to a new study. [More]
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